U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of vitamin metabolism

MedGen UID:
867647
•Concept ID:
C4022036
•
Finding
HPO: HP:0100508

Definition

An anomaly in the metabolism of a vitamin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of vitamin metabolism

Professional guidelines

PubMed

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Chronic Kidney Disease Diagnosis and Management: A Review.
Chen TK, Knicely DH, Grams ME
JAMA 2019 Oct 1;322(13):1294-1304. doi: 10.1001/jama.2019.14745. PMID: 31573641Free PMC Article
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia.
Haffner D, Emma F, Eastwood DM, Duplan MB, Bacchetta J, Schnabel D, Wicart P, Bockenhauer D, Santos F, Levtchenko E, Harvengt P, Kirchhoff M, Di Rocco F, Chaussain C, Brandi ML, Savendahl L, Briot K, Kamenicky P, Rejnmark L, Linglart A
Nat Rev Nephrol 2019 Jul;15(7):435-455. doi: 10.1038/s41581-019-0152-5. PMID: 31068690Free PMC Article

Recent clinical studies

Etiology

Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.
Ferrazzi E, Tiso G, Di Martino D
Eur J Obstet Gynecol Reprod Biol 2020 Oct;253:312-319. Epub 2020 Jun 13 doi: 10.1016/j.ejogrb.2020.06.012. PMID: 32868164
Folic acid and primary prevention of neural tube defects: A review.
van Gool JD, Hirche H, Lax H, De Schaepdrijver L
Reprod Toxicol 2018 Sep;80:73-84. Epub 2018 May 16 doi: 10.1016/j.reprotox.2018.05.004. PMID: 29777755
Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations.
Pfotenhauer KM, Shubrook JH
J Am Osteopath Assoc 2017 May 1;117(5):301-305. doi: 10.7556/jaoa.2017.055. PMID: 28459478
Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
Vitamin B12 in health and disease.
O'Leary F, Samman S
Nutrients 2010 Mar;2(3):299-316. Epub 2010 Mar 5 doi: 10.3390/nu2030299. PMID: 22254022Free PMC Article

Diagnosis

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.
Ko SH, Kim HS
Nutrients 2020 Jan 13;12(1) doi: 10.3390/nu12010202. PMID: 31941004Free PMC Article
Nutritional role of folate.
Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations.
Pfotenhauer KM, Shubrook JH
J Am Osteopath Assoc 2017 May 1;117(5):301-305. doi: 10.7556/jaoa.2017.055. PMID: 28459478
Inositol as putative integrative treatment for PCOS.
Genazzani AD
Reprod Biomed Online 2016 Dec;33(6):770-780. Epub 2016 Sep 16 doi: 10.1016/j.rbmo.2016.08.024. PMID: 27717596
Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113

Therapy

Homocysteine - from disease biomarker to disease prevention.
Smith AD, Refsum H
J Intern Med 2021 Oct;290(4):826-854. Epub 2021 Apr 6 doi: 10.1111/joim.13279. PMID: 33660358
Folic acid and primary prevention of neural tube defects: A review.
van Gool JD, Hirche H, Lax H, De Schaepdrijver L
Reprod Toxicol 2018 Sep;80:73-84. Epub 2018 May 16 doi: 10.1016/j.reprotox.2018.05.004. PMID: 29777755
Nutritional role of folate.
Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations.
Pfotenhauer KM, Shubrook JH
J Am Osteopath Assoc 2017 May 1;117(5):301-305. doi: 10.7556/jaoa.2017.055. PMID: 28459478
Vitamins and type 2 diabetes mellitus.
Valdés-Ramos R, Guadarrama-López AL, Martínez-Carrillo BE, Benítez-Arciniega AD
Endocr Metab Immune Disord Drug Targets 2015;15(1):54-63. doi: 10.2174/1871530314666141111103217. PMID: 25388747Free PMC Article

Prognosis

Neuroprotective Effect of Antioxidants in the Brain.
Lee KH, Cha M, Lee BH
Int J Mol Sci 2020 Sep 28;21(19) doi: 10.3390/ijms21197152. PMID: 32998277Free PMC Article
Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update.
Chitayat D, Matsui D, Amitai Y, Kennedy D, Vohra S, Rieder M, Koren G
J Clin Pharmacol 2016 Feb;56(2):170-5. Epub 2015 Nov 5 doi: 10.1002/jcph.616. PMID: 26272218Free PMC Article
The pathophysiology of elevated vitamin B12 in clinical practice.
Andrès E, Serraj K, Zhu J, Vermorken AJ
QJM 2013 Jun;106(6):505-15. Epub 2013 Feb 27 doi: 10.1093/qjmed/hct051. PMID: 23447660
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588
Drug-induced anaemias.
Girdwood RH
Drugs 1976;11(5):394-404. doi: 10.2165/00003495-197611050-00003. PMID: 782836

Clinical prediction guides

Guideline No. 427: Folic Acid and Multivitamin Supplementation for Prevention of Folic Acid-Sensitive Congenital Anomalies.
Wilson RD, O'Connor DL
J Obstet Gynaecol Can 2022 Jun;44(6):707-719.e1. doi: 10.1016/j.jogc.2022.04.004. PMID: 35691683
Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA).
Sabry W, Elemary M, Burnouf T, Seghatchian J, Goubran H
Transfus Apher Sci 2020 Feb;59(1):102717. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102717. PMID: 31902683
Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation.
Bhargava P, Fitzgerald KC, Calabresi PA, Mowry EM
JCI Insight 2017 Oct 5;2(19) doi: 10.1172/jci.insight.95302. PMID: 28978801Free PMC Article
Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update.
Chitayat D, Matsui D, Amitai Y, Kennedy D, Vohra S, Rieder M, Koren G
J Clin Pharmacol 2016 Feb;56(2):170-5. Epub 2015 Nov 5 doi: 10.1002/jcph.616. PMID: 26272218Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Recent systematic reviews

Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Comorbidities in alopecia areata: A systematic review and meta-analysis.
Lee S, Lee H, Lee CH, Lee WS
J Am Acad Dermatol 2019 Feb;80(2):466-477.e16. Epub 2018 Jul 18 doi: 10.1016/j.jaad.2018.07.013. PMID: 30031145
Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency.
Morris AA, Kožich V, Santra S, Andria G, Ben-Omran TI, Chakrapani AB, Crushell E, Henderson MJ, Hochuli M, Huemer M, Janssen MC, Maillot F, Mayne PD, McNulty J, Morrison TM, Ogier H, O'Sullivan S, Pavlíková M, de Almeida IT, Terry A, Yap S, Blom HJ, Chapman KA
J Inherit Metab Dis 2017 Jan;40(1):49-74. Epub 2016 Oct 24 doi: 10.1007/s10545-016-9979-0. PMID: 27778219Free PMC Article
Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.
Irani M, Merhi Z
Fertil Steril 2014 Aug;102(2):460-468.e3. Epub 2014 Jun 3 doi: 10.1016/j.fertnstert.2014.04.046. PMID: 24933120
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P
Cochrane Database Syst Rev 2013 May 31;2013(5):CD000951. doi: 10.1002/14651858.CD000951.pub2. PMID: 23728635Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...