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Cerebral inclusion bodies

MedGen UID:
867759
Concept ID:
C4022149
Disease or Syndrome
HPO: HP:0100314

Definition

Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain. [from HPO]

Professional guidelines

PubMed

Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL
Stroke 2019 Dec;50(12):e344-e418. Epub 2019 Oct 30 doi: 10.1161/STR.0000000000000211. PMID: 31662037
McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB
Neurology 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19 doi: 10.1212/01.wnl.0000187889.17253.b1. PMID: 16237129

Recent clinical studies

Etiology

Tian Y, Zhou L, Gao J, Jiao B, Zhang S, Xiao Q, Xue J, Wang Y, Liang H, Liu Y, Ji G, Mao C, Liu C, Dong L, Zhang L, Zhang S, Yi J, Zhao G, Luo Y, Sun Q, Zhou Y, Yi F, Chen X, Zhou C, Xie N, Luo M, Yao L, Hu Y, Zhang M, Zeng Q, Fang L, Long HY, Xie Y, Weng L, Chen S, Du J, Xu Q, Feng L, Huang Q, Hou X, Wang J, Xie B, Zhou L, Long L, Guo JF, Wang J, Yan X, Jiang H, Xu H, Duan R, Tang B, Shen L
J Neurol Neurosurg Psychiatry 2022 Dec;93(12):1289-1298. Epub 2022 Sep 23 doi: 10.1136/jnnp-2022-329772. PMID: 36150844Free PMC Article
Den Dunnen WFA
Handb Clin Neurol 2017;145:383-391. doi: 10.1016/B978-0-12-802395-2.00027-4. PMID: 28987184
Sone J, Mori K, Inagaki T, Katsumata R, Takagi S, Yokoi S, Araki K, Kato T, Nakamura T, Koike H, Takashima H, Hashiguchi A, Kohno Y, Kurashige T, Kuriyama M, Takiyama Y, Tsuchiya M, Kitagawa N, Kawamoto M, Yoshimura H, Suto Y, Nakayasu H, Uehara N, Sugiyama H, Takahashi M, Kokubun N, Konno T, Katsuno M, Tanaka F, Iwasaki Y, Yoshida M, Sobue G
Brain 2016 Dec;139(Pt 12):3170-3186. Epub 2016 Oct 25 doi: 10.1093/brain/aww249. PMID: 27797808Free PMC Article
Lanciego JL, Luquin N, Obeso JA
Cold Spring Harb Perspect Med 2012 Dec 1;2(12):a009621. doi: 10.1101/cshperspect.a009621. PMID: 23071379Free PMC Article
Hughes AJ, Daniel SE, Kilford L, Lees AJ
J Neurol Neurosurg Psychiatry 1992 Mar;55(3):181-4. doi: 10.1136/jnnp.55.3.181. PMID: 1564476Free PMC Article

Diagnosis

Zhang Y, Wu KM, Yang L, Dong Q, Yu JT
Mol Neurodegener 2022 Apr 7;17(1):28. doi: 10.1186/s13024-022-00533-z. PMID: 35392986Free PMC Article
Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
Nature 2020 Sep;585(7825):464-469. Epub 2020 May 27 doi: 10.1038/s41586-020-2317-6. PMID: 32461689Free PMC Article
Ellingwood SS, Cheng A
J Endocrinol 2018 Sep;238(3):R131-R141. Epub 2018 Jun 6 doi: 10.1530/JOE-18-0120. PMID: 29875163Free PMC Article
McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB
Neurology 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19 doi: 10.1212/01.wnl.0000187889.17253.b1. PMID: 16237129
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E
Neurobiol Aging 2003 Mar-Apr;24(2):197-211. doi: 10.1016/s0197-4580(02)00065-9. PMID: 12498954

Therapy

Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL
Stroke 2019 Dec;50(12):e344-e418. Epub 2019 Oct 30 doi: 10.1161/STR.0000000000000211. PMID: 31662037
Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS
Neuron 2019 Aug 21;103(4):627-641.e7. Epub 2019 Jun 26 doi: 10.1016/j.neuron.2019.05.035. PMID: 31255487Free PMC Article
Ellingwood SS, Cheng A
J Endocrinol 2018 Sep;238(3):R131-R141. Epub 2018 Jun 6 doi: 10.1530/JOE-18-0120. PMID: 29875163Free PMC Article
Wakabayashi K, Tanji K, Odagiri S, Miki Y, Mori F, Takahashi H
Mol Neurobiol 2013 Apr;47(2):495-508. Epub 2012 May 24 doi: 10.1007/s12035-012-8280-y. PMID: 22622968

Prognosis

Sengupta U, Kayed R
Prog Neurobiol 2022 Jul;214:102270. Epub 2022 Apr 18 doi: 10.1016/j.pneurobio.2022.102270. PMID: 35447272
Henderson MX, Trojanowski JQ, Lee VM
Neurosci Lett 2019 Sep 14;709:134316. Epub 2019 Jun 3 doi: 10.1016/j.neulet.2019.134316. PMID: 31170426Free PMC Article
Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL
Br J Sports Med 2017 Jun;51(12):969-977. Epub 2017 Apr 28 doi: 10.1136/bjsports-2017-097791. PMID: 28455362Free PMC Article
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E
Neurobiol Aging 2003 Mar-Apr;24(2):197-211. doi: 10.1016/s0197-4580(02)00065-9. PMID: 12498954

Clinical prediction guides

Sone J, Mitsuhashi S, Fujita A, Mizuguchi T, Hamanaka K, Mori K, Koike H, Hashiguchi A, Takashima H, Sugiyama H, Kohno Y, Takiyama Y, Maeda K, Doi H, Koyano S, Takeuchi H, Kawamoto M, Kohara N, Ando T, Ieda T, Kita Y, Kokubun N, Tsuboi Y, Katoh K, Kino Y, Katsuno M, Iwasaki Y, Yoshida M, Tanaka F, Suzuki IK, Frith MC, Matsumoto N, Sobue G
Nat Genet 2019 Aug;51(8):1215-1221. Epub 2019 Jul 22 doi: 10.1038/s41588-019-0459-y. PMID: 31332381
Ellingwood SS, Cheng A
J Endocrinol 2018 Sep;238(3):R131-R141. Epub 2018 Jun 6 doi: 10.1530/JOE-18-0120. PMID: 29875163Free PMC Article
Yang W, Yu S
Cell Mol Life Sci 2017 Apr;74(8):1485-1501. Epub 2016 Nov 8 doi: 10.1007/s00018-016-2411-y. PMID: 27826641
Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC Jr, Cooper JK, Sharp AH, Margolis RL, Borchelt DR
Philos Trans R Soc Lond B Biol Sci 1999 Jun 29;354(1386):1005-11. doi: 10.1098/rstb.1999.0452. PMID: 10434299Free PMC Article
Lenard HG
Neuropediatrics 1984 Sep;15 Suppl:16-9. doi: 10.1055/s-2008-1052375. PMID: 6100794

Recent systematic reviews

Maski K, Trotti LM, Kotagal S, Robert Auger R, Swick TJ, Rowley JA, Hashmi SD, Watson NF
J Clin Sleep Med 2021 Sep 1;17(9):1895-1945. doi: 10.5664/jcsm.9326. PMID: 34743790Free PMC Article
Buchanan SM, Richards M, Schott JM, Schrag A
Mov Disord 2021 Nov;36(11):2481-2493. Epub 2021 Sep 25 doi: 10.1002/mds.28777. PMID: 34562045
Longley V, Hazelton C, Heal C, Pollock A, Woodward-Nutt K, Mitchell C, Pobric G, Vail A, Bowen A
Cochrane Database Syst Rev 2021 Jul 1;7(7):CD003586. doi: 10.1002/14651858.CD003586.pub4. PMID: 34196963Free PMC Article
Connors MH, Quinto L, McKeith I, Brodaty H, Allan L, Bamford C, Thomas A, Taylor JP, O'Brien JT
Psychol Med 2018 Aug;48(11):1749-1758. Epub 2017 Nov 16 doi: 10.1017/S0033291717003257. PMID: 29143692Free PMC Article
Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL
Br J Sports Med 2017 Jun;51(12):969-977. Epub 2017 Apr 28 doi: 10.1136/bjsports-2017-097791. PMID: 28455362Free PMC Article

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