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Cerebral germinoma

MedGen UID:
867761
•Concept ID:
C4022151
•
Neoplastic Process
HPO: HP:0100312

Definition

The presence of a germ cell tumor of the cerebrum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral germinoma

Professional guidelines

PubMed

Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.
Kremenevski N, Buchfelder M, Hore N
Curr Oncol Rep 2023 Jul;25(7):765-775. Epub 2023 Apr 10 doi: 10.1007/s11912-023-01416-2. PMID: 37036624Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Diabetes insipidus--diagnosis and management.
Di Iorgi N, Napoli F, Allegri AE, Olivieri I, Bertelli E, Gallizia A, Rossi A, Maghnie M
Horm Res Paediatr 2012;77(2):69-84. Epub 2012 Mar 16 doi: 10.1159/000336333. PMID: 22433947

Recent clinical studies

Etiology

Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development.
Oslejskova H, Horinova V, Sterba J, Pavelka Z, Babovic-Vuksanovic D, Dubska L, Valik D
J Pediatr Hematol Oncol 2008 Sep;30(9):689-91. doi: 10.1097/MPH.0b013e318180bbde. PMID: 18776762

Diagnosis

Cerebral germinoma revealed through a polydipsic polyuric syndrome in a 10-year-old girl: case report.
Van Lierde L, Clapuyt P, Nassogne MC, Oriot P
Endocr Regul 2017 Oct 26;51(4):216-219. doi: 10.1515/enr-2017-0023. PMID: 29232188
Germinoma located in the basal ganglia in an 8-year-old girl.
Klein O, Voirin J, Civit T, Auque J, Marchal JC
Childs Nerv Syst 2007 Jan;23(1):105-8. Epub 2006 Oct 21 doi: 10.1007/s00381-006-0160-1. PMID: 17058090
De novo germinoma in the brain in association with Klinefelter's syndrome: case report and review of the literature.
Kaido T, Sasaoka Y, Hashimoto H, Taira K
Surg Neurol 2003 Dec;60(6):553-8; discussion 559. doi: 10.1016/s0090-3019(03)00454-3. PMID: 14670679
Cerebral germinoma with hemiatrophy of the brain: report of three cases.
Kim CH, Paek SH, Park IA, Chi JG, Kim DG
Acta Neurochir (Wien) 2002 Feb;144(2):145-50; discussion 150. doi: 10.1007/s007010200017. PMID: 11862514
Primary cerebral germinoma and ventriculoperitoneal shunt metastasis.
Kun LE, Tang TT, Sty JR, Camitta BM
Cancer 1981 Jul 1;48(1):213-6. doi: 10.1002/1097-0142(19810701)48:1<213::aid-cncr2820480134>3.0.co;2-5. PMID: 7237388

Therapy

Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult.
Sartori S, Laverda AM, Calderone M, Carollo C, Viscardi E, Faggin R, Perilongo G
Childs Nerv Syst 2007 Nov;23(11):1341-5. Epub 2007 Jul 3 doi: 10.1007/s00381-007-0390-x. PMID: 17609967
Germinoma located in the basal ganglia in an 8-year-old girl.
Klein O, Voirin J, Civit T, Auque J, Marchal JC
Childs Nerv Syst 2007 Jan;23(1):105-8. Epub 2006 Oct 21 doi: 10.1007/s00381-006-0160-1. PMID: 17058090
Klinefelter's syndrome, cerebral germinoma, Chiari malformation, and syrinx: a case report.
Ellis SJ, Crockard A, Barnard RO
Neurosurgery 1986 Feb;18(2):220-2. doi: 10.1227/00006123-198602000-00021. PMID: 2421193

Prognosis

Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development.
Oslejskova H, Horinova V, Sterba J, Pavelka Z, Babovic-Vuksanovic D, Dubska L, Valik D
J Pediatr Hematol Oncol 2008 Sep;30(9):689-91. doi: 10.1097/MPH.0b013e318180bbde. PMID: 18776762
Cerebral germinoma with syncytiotrophoblastic giant cells: feasibility of predicting prognosis using the serum hCG level.
Utsuki S, Kawano N, Oka H, Tanaka T, Suwa T, Fujii K
Acta Neurochir (Wien) 1999;141(9):975-7; discussion 977-8. doi: 10.1007/s007010050404. PMID: 10526079

Clinical prediction guides

Cerebral germinoma with syncytiotrophoblastic giant cells: feasibility of predicting prognosis using the serum hCG level.
Utsuki S, Kawano N, Oka H, Tanaka T, Suwa T, Fujii K
Acta Neurochir (Wien) 1999;141(9):975-7; discussion 977-8. doi: 10.1007/s007010050404. PMID: 10526079

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