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EMG: impaired neuromuscular transmission

MedGen UID:
867778
Concept ID:
C4022168
Finding
HPO: HP:0100285

Definition

An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP). [from HPO]

Recent clinical studies

Etiology

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Herbstreit F, Peters J, Eikermann M
Anesthesiology 2009 Jun;110(6):1253-60. doi: 10.1097/ALN.0b013e31819faa71. PMID: 19417617
Schindler-Ivens S, Brown DA, Lewis GN, Nielsen JB, Ondishko KL, Wieser J
Exp Brain Res 2008 Jul;188(3):465-74. Epub 2008 Apr 22 doi: 10.1007/s00221-008-1373-1. PMID: 18427793
Balci K, Turgut N, Nurlu G
Clin Neurophysiol 2005 Jul;116(7):1555-7. doi: 10.1016/j.clinph.2005.03.001. PMID: 15897007
Iwasaki H, Igarashi M, Omote K, Namiki A
J Clin Anesth 1994 Jan-Feb;6(1):14-7. doi: 10.1016/0952-8180(94)90111-2. PMID: 7908207

Diagnosis

Vincent A
Neuroscience 2020 Jul 15;439:48-61. Epub 2020 Mar 17 doi: 10.1016/j.neuroscience.2020.03.009. PMID: 32194225
Rubin DI
Handb Clin Neurol 2019;160:281-301. doi: 10.1016/B978-0-444-64032-1.00018-7. PMID: 31277854
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Plomp JJ, Morsch M, Phillips WD, Verschuuren JJ
Exp Neurol 2015 Aug;270:41-54. Epub 2015 Jan 23 doi: 10.1016/j.expneurol.2015.01.007. PMID: 25620417
Iwasaki H, Igarashi M, Omote K, Namiki A
J Clin Anesth 1994 Jan-Feb;6(1):14-7. doi: 10.1016/0952-8180(94)90111-2. PMID: 7908207

Therapy

Al-Muhaizea MA, AlQuait L, AlRasheed A, AlHarbi S, Albader AA, AlMass R, Albakheet A, Alhumaidan A, AlRasheed MM, Colak D, Kaya N
Neuromuscul Disord 2020 Jul;30(7):611-615. Epub 2020 May 15 doi: 10.1016/j.nmd.2020.04.007. PMID: 32616363
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Robb SA, Sewry CA, Dowling JJ, Feng L, Cullup T, Lillis S, Abbs S, Lees MM, Laporte J, Manzur AY, Knight RK, Mills KR, Pike MG, Kress W, Beeson D, Jungbluth H, Pitt MC, Muntoni F
Neuromuscul Disord 2011 Jun;21(6):379-86. Epub 2011 Mar 25 doi: 10.1016/j.nmd.2011.02.012. PMID: 21440438
Herbstreit F, Peters J, Eikermann M
Anesthesiology 2009 Jun;110(6):1253-60. doi: 10.1097/ALN.0b013e31819faa71. PMID: 19417617
Eikermann M, Gerwig M, Hasselmann C, Fiedler G, Peters J
Acta Anaesthesiol Scand 2007 Feb;51(2):226-34. doi: 10.1111/j.1399-6576.2006.01228.x. PMID: 17261149

Prognosis

Rubin DI
Handb Clin Neurol 2019;160:281-301. doi: 10.1016/B978-0-444-64032-1.00018-7. PMID: 31277854
Serrancolí G, Kinney AL, Fregly BJ, Font-Llagunes JM
J Biomech Eng 2016 Aug 1;138(8):0810011-08100111. doi: 10.1115/1.4033673. PMID: 27210105Free PMC Article
Karagiannopoulos C, Michlovitz S
J Hand Ther 2016 Apr-Jun;29(2):154-65. Epub 2015 Dec 12 doi: 10.1016/j.jht.2015.12.003. PMID: 26774958
Schindler-Ivens S, Brown DA, Lewis GN, Nielsen JB, Ondishko KL, Wieser J
Exp Brain Res 2008 Jul;188(3):465-74. Epub 2008 Apr 22 doi: 10.1007/s00221-008-1373-1. PMID: 18427793
Place N, Lepers R, Deley G, Millet GY
Med Sci Sports Exerc 2004 Aug;36(8):1347-56. doi: 10.1249/01.mss.0000135786.22996.77. PMID: 15292743

Clinical prediction guides

Inns TB, Bass JJ, Hardy EJO, Wilkinson DJ, Stashuk DW, Atherton PJ, Phillips BE, Piasecki M
J Physiol 2022 Nov;600(21):4753-4769. Epub 2022 Oct 5 doi: 10.1113/JP283425. PMID: 36088611Free PMC Article
Sarto F, Stashuk DW, Franchi MV, Monti E, Zampieri S, Valli G, Sirago G, Candia J, Hartnell LM, Paganini M, McPhee JS, De Vito G, Ferrucci L, Reggiani C, Narici MV
J Physiol 2022 Nov;600(21):4731-4751. Epub 2022 Sep 27 doi: 10.1113/JP283381. PMID: 36071599Free PMC Article
Serrancolí G, Kinney AL, Fregly BJ, Font-Llagunes JM
J Biomech Eng 2016 Aug 1;138(8):0810011-08100111. doi: 10.1115/1.4033673. PMID: 27210105Free PMC Article
Schindler-Ivens S, Brown DA, Lewis GN, Nielsen JB, Ondishko KL, Wieser J
Exp Brain Res 2008 Jul;188(3):465-74. Epub 2008 Apr 22 doi: 10.1007/s00221-008-1373-1. PMID: 18427793
Splendiani G, Cipriani S, Passalacqua S, Sturniolo A, Costanzi S, Fulignati P, Staffolani E, Casciani CU
Artif Cells Blood Substit Immobil Biotechnol 2003 Feb;31(1):69-79. doi: 10.1081/bio-120018004. PMID: 12602818

Recent systematic reviews

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article

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