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Chagas disease with heart involvement

MedGen UID:
868
Concept ID:
C0007930
Disease or Syndrome
Synonyms: Cardiomyopathy, Chagas; Cardiomyopathy, Chagas'; Cardiovascular Trypanosomiasis; Chagas Cardiomyopathy; Chagas' Cardiomyopathy; Trypanosomiasis, Cardiovascular
SNOMED CT: Chagas' disease with heart involvement (998008)

Definition

A dilated cardiomyopathy caused by the protozoan Trypanosoma cruzi. Patients may present with heart block, congestive heart failure, or anginal symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChagas disease with heart involvement

Professional guidelines

PubMed

Santos É, Menezes Falcão L
Rev Port Cardiol (Engl Ed) 2020 May;39(5):279-289. Epub 2020 Jun 10 doi: 10.1016/j.repc.2019.12.006. PMID: 32532535
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432

Recent clinical studies

Etiology

Zaidel EJ, Forsyth CJ, Novick G, Marcus R, Ribeiro ALP, Pinazo MJ, Morillo CA, Echeverría LE, Shikanai-Yasuda MA, Buekens P, Perel P, Meymandi SK, Ralston K, Pinto F, Sosa-Estani S
Glob Heart 2020 Oct 13;15(1):69. doi: 10.5334/gh.891. PMID: 33150134Free PMC Article
Velasco A, Morillo CA
J Nucl Cardiol 2020 Apr;27(2):445-451. Epub 2018 Jul 18 doi: 10.1007/s12350-018-1361-1. PMID: 30022404
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432
Malik LH, Singh GD, Amsterdam EA
Clin Cardiol 2015 Sep;38(9):565-9. Epub 2015 May 21 doi: 10.1002/clc.22421. PMID: 25993972Free PMC Article
Rassi A Jr, Rassi A, Marin-Neto JA
Lancet 2010 Apr 17;375(9723):1388-402. doi: 10.1016/S0140-6736(10)60061-X. PMID: 20399979

Diagnosis

Echavarría NG, Echeverría LE, Stewart M, Gallego C, Saldarriaga C
Curr Probl Cardiol 2021 Mar;46(3):100507. Epub 2019 Dec 1 doi: 10.1016/j.cpcardiol.2019.100507. PMID: 31983471
Santos É, Menezes Falcão L
Rev Port Cardiol (Engl Ed) 2020 May;39(5):279-289. Epub 2020 Jun 10 doi: 10.1016/j.repc.2019.12.006. PMID: 32532535
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432
Mangini S, Alves BR, Silvestre OM, Pires PV, Pires LJ, Curiati MN, Bacal F
Einstein (Sao Paulo) 2015 Apr-Jun;13(2):310-8. doi: 10.1590/S1679-45082015RW3154. PMID: 26154552Free PMC Article
Rassi A Jr, Rassi A, Marin-Neto JA
Lancet 2010 Apr 17;375(9723):1388-402. doi: 10.1016/S0140-6736(10)60061-X. PMID: 20399979

Therapy

Santos É, Menezes Falcão L
Rev Port Cardiol (Engl Ed) 2020 May;39(5):279-289. Epub 2020 Jun 10 doi: 10.1016/j.repc.2019.12.006. PMID: 32532535
Echeverria LE, Morillo CA
Infect Dis Clin North Am 2019 Mar;33(1):119-134. doi: 10.1016/j.idc.2018.10.015. PMID: 30712757
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432
Trachtenberg BH, Hare JM
Circ Res 2017 Sep 15;121(7):803-818. doi: 10.1161/CIRCRESAHA.117.310221. PMID: 28912184
Rassi A Jr, Rassi A, Marin-Neto JA
Lancet 2010 Apr 17;375(9723):1388-402. doi: 10.1016/S0140-6736(10)60061-X. PMID: 20399979

Prognosis

Santos É, Menezes Falcão L
Rev Port Cardiol (Engl Ed) 2020 May;39(5):279-289. Epub 2020 Jun 10 doi: 10.1016/j.repc.2019.12.006. PMID: 32532535
Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM
Annu Rev Pathol 2019 Jan 24;14:421-447. Epub 2018 Oct 24 doi: 10.1146/annurev-pathol-020117-043711. PMID: 30355152Free PMC Article
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432
Pérez-Molina JA, Molina I
Lancet 2018 Jan 6;391(10115):82-94. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31612-4. PMID: 28673423
Nunes MC, Dones W, Morillo CA, Encina JJ, Ribeiro AL; Council on Chagas Disease of the Interamerican Society of Cardiology
J Am Coll Cardiol 2013 Aug 27;62(9):767-76. Epub 2013 Jun 13 doi: 10.1016/j.jacc.2013.05.046. PMID: 23770163

Clinical prediction guides

Nunes JPS, Andrieux P, Brochet P, Almeida RR, Kitano E, Honda AK, Iwai LK, Andrade-Silva D, Goudenège D, Alcântara Silva KD, Vieira RS, Levy D, Bydlowski SP, Gallardo F, Torres M, Bocchi EA, Mano M, Santos RHB, Bacal F, Pomerantzeff P, Laurindo FRM, Teixeira PC, Nakaya HI, Kalil J, Procaccio V, Chevillard C, Cunha-Neto E
Front Immunol 2021;12:755862. Epub 2021 Nov 11 doi: 10.3389/fimmu.2021.755862. PMID: 34867992Free PMC Article
Velasco A, Morillo CA
J Nucl Cardiol 2020 Apr;27(2):445-451. Epub 2018 Jul 18 doi: 10.1007/s12350-018-1361-1. PMID: 30022404
Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM
Annu Rev Pathol 2019 Jan 24;14:421-447. Epub 2018 Oct 24 doi: 10.1146/annurev-pathol-020117-043711. PMID: 30355152Free PMC Article
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, Dutra WO, Gascon J, Morillo CA, Oliveira-Filho J, Ribeiro ALP, Marin-Neto JA; American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Stroke Council
Circulation 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599. PMID: 30354432
Brito BOF, Ribeiro ALP
Rev Soc Bras Med Trop 2018 Sep-Oct;51(5):570-577. doi: 10.1590/0037-8682-0184-2018. PMID: 30304260

Recent systematic reviews

Echeverría LE, Rojas LZ, Gómez-Ochoa SA
Thromb Res 2021 May;201:73-83. Epub 2021 Feb 27 doi: 10.1016/j.thromres.2021.02.025. PMID: 33652329
Costa HS, Lima MMO, Costa FSMD, Chaves AT, Nunes MCP, Figueiredo PHS, Rocha MODC
Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):421-426. doi: 10.1590/0037-8682-0158-2018. PMID: 30133623
Rojas LZ, Glisic M, Pletsch-Borba L, Echeverría LE, Bramer WM, Bano A, Stringa N, Zaciragic A, Kraja B, Asllanaj E, Chowdhury R, Morillo CA, Rueda-Ochoa OL, Franco OH, Muka T
PLoS Negl Trop Dis 2018 Jun;12(6):e0006567. Epub 2018 Jun 13 doi: 10.1371/journal.pntd.0006567. PMID: 29897909Free PMC Article
Ciapponi A, Alcaraz A, Calderón M, Matta MG, Chaparro M, Soto N, Bardach A
Rev Esp Cardiol (Engl Ed) 2016 Nov;69(11):1051-1060. Epub 2016 Aug 21 doi: 10.1016/j.rec.2016.04.054. PMID: 27553287
de Oliveira AP, Ayo CM, Bestetti RB, Brandão de Mattos CC, Cavasini CE, de Mattos LC
Infect Genet Evol 2016 Nov;45:132-137. Epub 2016 Aug 15 doi: 10.1016/j.meegid.2016.08.012. PMID: 27539514

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