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Increased sarcoplasmic glycogen

MedGen UID:
868174
•Concept ID:
C4022566
•
Finding
HPO: HP:0030232

Definition

Elevated glycogen content in the sarcoplasm (cytoplasm) of muscle fibers. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased sarcoplasmic glycogen

Professional guidelines

PubMed

Selective screening of late-onset Pompe disease (LOPD) in patients with non-diagnostic muscle biopsies.
Meznaric M, Fumic K, Leonardis L
J Clin Pathol 2019 Jul;72(7):468-472. Epub 2019 Mar 16 doi: 10.1136/jclinpath-2018-205446. PMID: 30878973
The role of lipid peroxidation in McArdle's disease: applications for treatment of other myopathies.
Russo PJ, Phillips JW, Seidler NW
Med Hypotheses 1992 Oct;39(2):147-51. doi: 10.1016/0306-9877(92)90176-d. PMID: 1461177
Analysis of histopathologic findings in cases with dilated cardiomyopathy with special reference to formulating diagnostic criteria on the possibility of postmyocarditic change.
Hasumi M, Sekiguchi M, Yu ZX, Hirosawa K, Hiroe M
Jpn Circ J 1986 Dec;50(12):1280-7. doi: 10.1253/jcj.50.1280. PMID: 3820536

Recent clinical studies

Etiology

The Role of Muscle Glycogen Content and Localization in High-Intensity Exercise Performance: A Placebo-Controlled Trial.
Vigh-Larsen JF, Ørtenblad N, Nielsen J, Emil Andersen O, Overgaard K, Mohr M
Med Sci Sports Exerc 2022 Dec 1;54(12):2073-2086. Epub 2022 Jul 15 doi: 10.1249/MSS.0000000000003002. PMID: 35868015
Selective screening of late-onset Pompe disease (LOPD) in patients with non-diagnostic muscle biopsies.
Meznaric M, Fumic K, Leonardis L
J Clin Pathol 2019 Jul;72(7):468-472. Epub 2019 Mar 16 doi: 10.1136/jclinpath-2018-205446. PMID: 30878973
Light and electron microscopic features of surgically excised left atrial appendage in rheumatic heart disease patients with atrial fibrillation and sinus rhythm.
Sharma S, Sharma G, Hote M, Devagourou V, Kesari V, Arava S, Airan B, Ray R
Cardiovasc Pathol 2014 Nov-Dec;23(6):319-26. Epub 2014 Aug 6 doi: 10.1016/j.carpath.2014.07.008. PMID: 25216788
Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers.
Tarnopolsky M, Cupido C
J Appl Physiol (1985) 2000 Nov;89(5):1719-24. doi: 10.1152/jappl.2000.89.5.1719. PMID: 11053318
Caffeine and endurance performance.
Tarnopolsky MA
Sports Med 1994 Aug;18(2):109-25. doi: 10.2165/00007256-199418020-00004. PMID: 9132918

Diagnosis

The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy.
de Melo Madureira ÁN, de Oliveira JRS, de Menezes Lima VL
Mini Rev Med Chem 2022;22(18):2419-2428. doi: 10.2174/1389557522666220309161245. PMID: 35264090
Deep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment.
Laforêt P, Inoue M, Goillot E, Lefeuvre C, Cagin U, Streichenberger N, Leonard-Louis S, Brochier G, Madelaine A, Labasse C, Hedberg-Oldfors C, Krag T, Jauze L, Fabregue J, Labrune P, Milisenda J, Nadaj-Pakleza A, Sacconi S, Mingozzi F, Ronzitti G, Petit F, Schoser B, Oldfors A, Vissing J, Romero NB, Nishino I, Malfatti E
Acta Neuropathol Commun 2019 Oct 28;7(1):167. doi: 10.1186/s40478-019-0815-2. PMID: 31661040Free PMC Article
Utilization of lipids during exercise in human subjects: metabolic and dietary constraints.
Brouns F, van der Vusse GJ
Br J Nutr 1998 Feb;79(2):117-28. doi: 10.1079/bjn19980022. PMID: 9536855
Caffeine and sports activity: a review.
Nehlig A, Debry G
Int J Sports Med 1994 Jul;15(5):215-23. doi: 10.1055/s-2007-1021049. PMID: 7960313
Muscle damage produced by chronic alcohol consumption.
Rubin E, Katz AM, Lieber CS, Stein EP, Puszkin S
Am J Pathol 1976 Jun;83(3):499-516. PMID: 132869Free PMC Article

Therapy

The Role of Muscle Glycogen Content and Localization in High-Intensity Exercise Performance: A Placebo-Controlled Trial.
Vigh-Larsen JF, Ørtenblad N, Nielsen J, Emil Andersen O, Overgaard K, Mohr M
Med Sci Sports Exerc 2022 Dec 1;54(12):2073-2086. Epub 2022 Jul 15 doi: 10.1249/MSS.0000000000003002. PMID: 35868015
Muscle fiber hypertrophy in response to 6 weeks of high-volume resistance training in trained young men is largely attributed to sarcoplasmic hypertrophy.
Haun CT, Vann CG, Osburn SC, Mumford PW, Roberson PA, Romero MA, Fox CD, Johnson CA, Parry HA, Kavazis AN, Moon JR, Badisa VLD, Mwashote BM, Ibeanusi V, Young KC, Roberts MD
PLoS One 2019;14(6):e0215267. Epub 2019 Jun 5 doi: 10.1371/journal.pone.0215267. PMID: 31166954Free PMC Article
Metabolic and sarcoplasmic reticulum Ca2+ cycling responses in human muscle 4 days following prolonged exercise.
Duhamel TA, Green HJ, Perco JG, Ouyang J
Can J Physiol Pharmacol 2005 Jul;83(7):643-55. doi: 10.1139/y05-049. PMID: 16091790
Enhanced sarcoplasmic reticulum Ca(2+) release following intermittent sprint training.
Ortenblad N, Lunde PK, Levin K, Andersen JL, Pedersen PK
Am J Physiol Regul Integr Comp Physiol 2000 Jul;279(1):R152-60. doi: 10.1152/ajpregu.2000.279.1.R152. PMID: 10896877
Muscle damage produced by chronic alcohol consumption.
Rubin E, Katz AM, Lieber CS, Stein EP, Puszkin S
Am J Pathol 1976 Jun;83(3):499-516. PMID: 132869Free PMC Article

Prognosis

Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise.
Parolin ML, Chesley A, Matsos MP, Spriet LL, Jones NL, Heigenhauser GJ
Am J Physiol 1999 Nov;277(5):E890-900. doi: 10.1152/ajpendo.1999.277.5.E890. PMID: 10567017
Caffeine and endurance performance.
Tarnopolsky MA
Sports Med 1994 Aug;18(2):109-25. doi: 10.2165/00007256-199418020-00004. PMID: 9132918

Clinical prediction guides

The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy.
de Melo Madureira ÁN, de Oliveira JRS, de Menezes Lima VL
Mini Rev Med Chem 2022;22(18):2419-2428. doi: 10.2174/1389557522666220309161245. PMID: 35264090
Comparative proteomic analyses of Duchenne muscular dystrophy and Becker muscular dystrophy muscles: changes contributing to preserve muscle function in Becker muscular dystrophy patients.
Capitanio D, Moriggi M, Torretta E, Barbacini P, De Palma S, Viganò A, Lochmüller H, Muntoni F, Ferlini A, Mora M, Gelfi C
J Cachexia Sarcopenia Muscle 2020 Apr;11(2):547-563. Epub 2020 Jan 28 doi: 10.1002/jcsm.12527. PMID: 31991054Free PMC Article
Utilization of lipids during exercise in human subjects: metabolic and dietary constraints.
Brouns F, van der Vusse GJ
Br J Nutr 1998 Feb;79(2):117-28. doi: 10.1079/bjn19980022. PMID: 9536855
Mechanisms of muscle fatigue in intense exercise.
Green HJ
J Sports Sci 1997 Jun;15(3):247-56. doi: 10.1080/026404197367254. PMID: 9232550
Caffeine and endurance performance.
Tarnopolsky MA
Sports Med 1994 Aug;18(2):109-25. doi: 10.2165/00007256-199418020-00004. PMID: 9132918

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