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Enlarged brainstem

MedGen UID:
868347
Concept ID:
C4022741
Finding
HPO: HP:0012755

Definition

Abnormal increase in size of the brainstem. [from HPO]

Professional guidelines

PubMed

Guo H, Deng Z, Xu Q, Wang Z, Zeng X, Hong X, Wang Q, Sun Y, Yuan H
J Matern Fetal Neonatal Med 2023 Dec;36(2):2250895. doi: 10.1080/14767058.2023.2250895. PMID: 37635087
Charisis S, Rashid T, Liu H, Ware JB, Jensen PN, Austin TR, Li K, Fadaee E, Hilal S, Chen C, Hughes TM, Romero JR, Toledo JB, Longstreth WT Jr, Hohman TJ, Nasrallah I, Bryan RN, Launer LJ, Davatzikos C, Seshadri S, Heckbert SR, Habes M
JAMA Netw Open 2023 Apr 3;6(4):e239196. doi: 10.1001/jamanetworkopen.2023.9196. PMID: 37093602Free PMC Article
Perry J, Sher E, Kawai K, Redfield S, Sun T, Kenna M
Laryngoscope 2023 Oct;133(10):2786-2791. Epub 2023 Feb 10 doi: 10.1002/lary.30605. PMID: 36762450

Recent clinical studies

Etiology

Imai R, Tamura R, Yo M, Sato M, Fukumura M, Takahara K, Kase Y, Okano H, Toda M
Stem Cells 2023 Jun 15;41(6):603-616. doi: 10.1093/stmcls/sxad028. PMID: 37029780Free PMC Article
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T Jr, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT
Nat Neurosci 2022 Apr;25(4):458-473. Epub 2022 Apr 4 doi: 10.1038/s41593-022-01043-3. PMID: 35379995Free PMC Article
Bertini E, Zanni G, Boltshauser E
Handb Clin Neurol 2018;155:91-103. doi: 10.1016/B978-0-444-64189-2.00006-8. PMID: 29891079
Zimmerman RS, Frohlich ED
J Hypertens Suppl 1990 Sep;8(4):S103-7. PMID: 2258776

Diagnosis

Walker C
JAAPA 2024 Feb 1;37(2):1-4. doi: 10.1097/01.JAA.0000995640.85221.b0. PMID: 38270661
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
Hashizume Y
Neuropathology 2022 Oct;42(5):353-366. Epub 2022 Apr 21 doi: 10.1111/neup.12785. PMID: 35451141
Moskalik A, Kercher M, Vitt J, Lee HS, Waldau B
Neurochirurgie 2022 Dec;68(6):e97-e100. Epub 2022 Mar 18 doi: 10.1016/j.neuchi.2022.02.007. PMID: 35314067
Wang H, Wang Y, Wang R, Li Y, Wang P, Li J, Du J
Brain Res 2019 Sep 1;1718:53-63. Epub 2019 Apr 23 doi: 10.1016/j.brainres.2019.04.024. PMID: 31026459

Therapy

Galkin A, Sitapara R, Clemons B, Garcia E, Kennedy M, Guimond D, Carter LL, Douthitt A, Osterhout R, Gandjeva A, Slee D, Salter-Cid L, Tuder RM, Zisman LS
Eur Respir J 2022 Dec;60(6) Epub 2022 Dec 1 doi: 10.1183/13993003.02356-2021. PMID: 35680144Free PMC Article
Micklethwaite KP, Gowrishankar K, Gloss BS, Li Z, Street JA, Moezzi L, Mach MA, Sutrave G, Clancy LE, Bishop DC, Louie RHY, Cai C, Foox J, MacKay M, Sedlazeck FJ, Blombery P, Mason CE, Luciani F, Gottlieb DJ, Blyth E
Blood 2021 Oct 21;138(16):1391-1405. doi: 10.1182/blood.2021010858. PMID: 33974080Free PMC Article
Leiner HC
Neuropsychol Rev 2010 Sep;20(3):229-35. Epub 2010 Sep 1 doi: 10.1007/s11065-010-9140-z. PMID: 20809199
Reid JL
Am J Hypertens 2001 Nov;14(11 Pt 2):322S-324S. doi: 10.1016/s0895-7061(01)02239-7. PMID: 11721891
Leys D, Lucas C, Gobert M, Deklunder G, Pruvo JP
Eur Neurol 1997;37(1):3-12. doi: 10.1159/000117396. PMID: 9018025

Prognosis

Walker C
JAAPA 2024 Feb 1;37(2):1-4. doi: 10.1097/01.JAA.0000995640.85221.b0. PMID: 38270661
Paramasivam S
Neurol India 2021 Nov-Dec;69(Supplement):S376-S379. doi: 10.4103/0028-3886.332279. PMID: 35102992
Harris TC, de Rooij R, Kuhl E
Ann Biomed Eng 2019 Sep;47(9):1941-1959. Epub 2018 Oct 17 doi: 10.1007/s10439-018-02148-2. PMID: 30341741Free PMC Article
Bertini E, Zanni G, Boltshauser E
Handb Clin Neurol 2018;155:91-103. doi: 10.1016/B978-0-444-64189-2.00006-8. PMID: 29891079
Leys D, Lucas C, Gobert M, Deklunder G, Pruvo JP
Eur Neurol 1997;37(1):3-12. doi: 10.1159/000117396. PMID: 9018025

Clinical prediction guides

Shkarubo AN, Chernov IV, Veselkov AA, Andreev DN, Sinelnikov ME, Karnaukhov VV, Yakupova ZF
Zh Vopr Neirokhir Im N N Burdenko 2023;87(4):27-34. doi: 10.17116/neiro20238704127. PMID: 37650274
Duy PQ, Greenberg ABW, Butler WE, Kahle KT
Neurobiol Dis 2022 Dec;175:105913. Epub 2022 Oct 29 doi: 10.1016/j.nbd.2022.105913. PMID: 36341771
Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y
Mol Neurodegener 2021 Apr 14;16(1):25. doi: 10.1186/s13024-021-00442-7. PMID: 33853653Free PMC Article
Molnár Z, Clowry GJ, Šestan N, Alzu'bi A, Bakken T, Hevner RF, Hüppi PS, Kostović I, Rakic P, Anton ES, Edwards D, Garcez P, Hoerder-Suabedissen A, Kriegstein A
J Anat 2019 Sep;235(3):432-451. Epub 2019 Aug 2 doi: 10.1111/joa.13055. PMID: 31373394Free PMC Article
Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK
World Neurosurg 2018 Apr;112:e763-e771. Epub 2018 Jan 31 doi: 10.1016/j.wneu.2018.01.150. PMID: 29382617

Recent systematic reviews

Stoian A, Bajko Z, Bălașa R, Andone S, Stoian M, Ormenișan I, Muntean C, Bănescu C
Biomolecules 2024 Feb 23;14(3) doi: 10.3390/biom14030270. PMID: 38540691Free PMC Article
Motoyama Y, Sasaki H, Nakajima T, Hayami H, Matsuoka R, Fukutome K, Tei R, Shin Y, Aketa S
Acta Neurochir (Wien) 2024 Jan 17;166(1):20. doi: 10.1007/s00701-024-05900-x. PMID: 38231302
Ogut E, Armagan K, Tufekci D
Neurosurg Rev 2023 Jul 20;46(1):181. doi: 10.1007/s10143-023-02086-1. PMID: 37468768
Gripp KW, Hopkins E, Doyle D, Dobyns WB
Am J Med Genet A 2010 May;152A(5):1161-8. doi: 10.1002/ajmg.a.33391. PMID: 20425820Free PMC Article
Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM
Eur Psychiatry 2008 Jun;23(4):289-99. Epub 2007 Aug 31 doi: 10.1016/j.eurpsy.2007.05.006. PMID: 17765485

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