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T2 hypointense brainstem

MedGen UID:
868352
Concept ID:
C4022746
Finding
HPO: HP:0012750

Definition

A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a diffuse hypointensity affecting the entire brainstem. [from HPO]

Professional guidelines

PubMed

Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Jiang J, Wang J, Lin M, Wang X, Zhao J, Shang X
Brain Behav 2020 Oct;10(10):e01778. Epub 2020 Aug 5 doi: 10.1002/brb3.1778. PMID: 32755074Free PMC Article
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Recent clinical studies

Etiology

Li L, Liu W, Cai Q, Liu Y, Hu W, Zuo Z, Ma Q, He S, Jin K
Front Immunol 2023;14:1152235. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1152235. PMID: 37409120Free PMC Article
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Koemans EA, Voigt S, Rasing I, van Harten TW, Jolink WMT, Schreuder FHBM, van Zwet EW, van Buchem MA, van Osch MJP, Terwindt GM, Klijn CJM, van Walderveen MAA, Wermer MJH
Stroke 2022 Feb;53(2):552-557. Epub 2021 Sep 20 doi: 10.1161/STROKEAHA.121.035019. PMID: 34538086
Jiang J, Wang J, Lin M, Wang X, Zhao J, Shang X
Brain Behav 2020 Oct;10(10):e01778. Epub 2020 Aug 5 doi: 10.1002/brb3.1778. PMID: 32755074Free PMC Article
Borhani Haghighi A, Pourmand R, Nikseresht AR
Neurologist 2005 Mar;11(2):80-9. doi: 10.1097/01.nrl.0000156343.16797.c4. PMID: 15733330

Diagnosis

Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Boddaert N, Brunelle F, Desguerre I
Handb Clin Neurol 2013;111:63-78. doi: 10.1016/B978-0-444-52891-9.00006-3. PMID: 23622151
Borhani Haghighi A, Pourmand R, Nikseresht AR
Neurologist 2005 Mar;11(2):80-9. doi: 10.1097/01.nrl.0000156343.16797.c4. PMID: 15733330
Abe T, Kojima K, Shoji H, Tanaka N, Fujimoto K, Uchida M, Nishimura H, Hayabuchi N, Norbash AM
J Magn Reson Imaging 1998 Jul-Aug;8(4):755-61. doi: 10.1002/jmri.1880080402. PMID: 9702874

Therapy

Esparragosa Vazquez I, Ndiaye M, Di Stefano AL, Younan N, Larrieu-Ciron D, Seyve A, Picart T, Meyronet D, Boutet C, Vassal F, Carpentier C, Figarella-Branger D, Dehais C, Forest F, Rivoirard R, Ducray F; POLA network
Eur J Neurol 2023 Sep;30(9):2879-2883. Epub 2023 May 31 doi: 10.1111/ene.15873. PMID: 37204066
Yeat CM, Achmad Sankala H, Mohd Zaki F, Mohamed Mukari SA
BMJ Case Rep 2022 Sep 15;15(9) doi: 10.1136/bcr-2022-251672. PMID: 36109096Free PMC Article
Nose Y, Uwano I, Tateishi U, Sasaki M, Yokota T, Sanjo N
J Neurol 2022 May;269(5):2539-2548. Epub 2021 Oct 18 doi: 10.1007/s00415-021-10844-8. PMID: 34664101
Hobbs K, Stern-Nezer S, Buckwalter MS, Fischbein N, Finley Caulfield A
Neurocrit Care 2015 Jun;22(3):429-36. doi: 10.1007/s12028-014-0102-9. PMID: 25561434
Hecht MJ, Fellner F, Fellner C, Hilz MJ, Neundörfer B, Heuss D
J Neurol Sci 2002 Jul 15;199(1-2):59-65. doi: 10.1016/s0022-510x(02)00104-1. PMID: 12084444

Prognosis

Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Varadan B, Shankar A, Rajakumar A, Subramanian S, Sathya AC, Hakeem AR, Kalyanasundaram S
Neuroradiology 2021 May;63(5):653-661. Epub 2021 Feb 11 doi: 10.1007/s00234-021-02667-1. PMID: 33575849Free PMC Article
Borhani Haghighi A, Pourmand R, Nikseresht AR
Neurologist 2005 Mar;11(2):80-9. doi: 10.1097/01.nrl.0000156343.16797.c4. PMID: 15733330
Abe T, Kojima K, Shoji H, Tanaka N, Fujimoto K, Uchida M, Nishimura H, Hayabuchi N, Norbash AM
J Magn Reson Imaging 1998 Jul-Aug;8(4):755-61. doi: 10.1002/jmri.1880080402. PMID: 9702874
Pollack IF, Shultz B, Mulvihill JJ
Neurology 1996 Jun;46(6):1652-60. doi: 10.1212/wnl.46.6.1652. PMID: 8649565

Clinical prediction guides

Láinez-Ramos Bossini AJ, Redruello-Guerrero P, Martínez-Barbero JP, Gutiérrez-Jiménez P, Gutiérrez-Jiménez C, Rivera-Izquierdo M
Rev Neurol 2023 Jun 16;76(12):385-390. doi: 10.33588/rn.7612.2023020. PMID: 37303100Free PMC Article
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Nose Y, Uwano I, Tateishi U, Sasaki M, Yokota T, Sanjo N
J Neurol 2022 May;269(5):2539-2548. Epub 2021 Oct 18 doi: 10.1007/s00415-021-10844-8. PMID: 34664101
Jiang J, Wang J, Lin M, Wang X, Zhao J, Shang X
Brain Behav 2020 Oct;10(10):e01778. Epub 2020 Aug 5 doi: 10.1002/brb3.1778. PMID: 32755074Free PMC Article
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193

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