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Abnormal thalamic MRI signal intensity

MedGen UID:
868376
•Concept ID:
C4022770
•
Finding
HPO: HP:0012696

Definition

A deviation from normal signal on magnetic resonance imaging (MRI) of the thalamus. [from HPO]

Professional guidelines

PubMed

Neuro-behçet's disease in South Korea: clinical characteristics and treatment response.
Yoon DL, Kim YJ, Koo BS, Kim YG, Lee CK, Yoo B
Int J Rheum Dis 2014 May;17(4):453-8. Epub 2014 Feb 8 doi: 10.1111/1756-185X.12265. PMID: 24506839
Early differential diagnosis of infantile neuronal ceroid lipofuscinosis, Rett syndrome, and Krabbe disease by CT and MR.
Vanhanen SL, Raininko R, Santavuori P
AJNR Am J Neuroradiol 1994 Sep;15(8):1443-53. PMID: 7985561Free PMC Article

Recent clinical studies

Etiology

MRI abnormalities in Creutzfeldt-Jakob disease and other rapidly progressive dementia.
Manara R, Fragiacomo F, Ladogana A, Vaianella L, Camporese G, Zorzi G, Vicinanza S, Zanusso G, Pocchiari M, Cagnin A
J Neurol 2024 Jan;271(1):300-309. Epub 2023 Sep 12 doi: 10.1007/s00415-023-11962-1. PMID: 37698615Free PMC Article
Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias.
Waugh JL, Kuster JK, Levenstein JM, Makris N, Multhaupt-Buell TJ, Sudarsky LR, Breiter HC, Sharma N, Blood AJ
PLoS One 2016;11(5):e0155302. Epub 2016 May 12 doi: 10.1371/journal.pone.0155302. PMID: 27171035Free PMC Article
Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Predicting motor outcome and death in term hypoxic-ischemic encephalopathy.
Martinez-Biarge M, Diez-Sebastian J, Kapellou O, Gindner D, Allsop JM, Rutherford MA, Cowan FM
Neurology 2011 Jun 14;76(24):2055-61. doi: 10.1212/WNL.0b013e31821f442d. PMID: 21670434Free PMC Article
Thalamic damage and long-term progression of disability in multiple sclerosis.
Rocca MA, Mesaros S, Pagani E, Sormani MP, Comi G, Filippi M
Radiology 2010 Nov;257(2):463-9. Epub 2010 Aug 19 doi: 10.1148/radiol.10100326. PMID: 20724544

Diagnosis

MRI abnormalities in Creutzfeldt-Jakob disease and other rapidly progressive dementia.
Manara R, Fragiacomo F, Ladogana A, Vaianella L, Camporese G, Zorzi G, Vicinanza S, Zanusso G, Pocchiari M, Cagnin A
J Neurol 2024 Jan;271(1):300-309. Epub 2023 Sep 12 doi: 10.1007/s00415-023-11962-1. PMID: 37698615Free PMC Article
3T MRI signal intensity profiles and thicknesses of transient zones in human fetal brain at mid-gestation.
Pogledic I, Schwartz E, Bobić-Rasonja M, Mitter C, Baltzer P, Gruber GM, Milković-Periša M, Haberler C, Bettelheim D, Kasprian G, Judaš M, Prayer D, Jovanov-Milošević N
Eur J Paediatr Neurol 2021 Nov;35:67-73. Epub 2021 Oct 9 doi: 10.1016/j.ejpn.2021.09.014. PMID: 34653829
Contribution of metals to brain MR signal intensity: review articles.
Kanda T, Nakai Y, Aoki S, Oba H, Toyoda K, Kitajima K, Furui S
Jpn J Radiol 2016 Apr;34(4):258-66. Epub 2016 Mar 1 doi: 10.1007/s11604-016-0532-8. PMID: 26932404
Bilateral symmetrical basal ganglia and thalamic lesions in children: an update (2015).
Zuccoli G, Yannes MP, Nardone R, Bailey A, Goldstein A
Neuroradiology 2015 Oct;57(10):973-89. Epub 2015 Jul 31 doi: 10.1007/s00234-015-1568-7. PMID: 26227169
Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452

Therapy

Peduncular hallucinosis associated with pontine hemorrhage in an adult patient.
Papantoniou M, Panagou G, Gryllia M
Psychiatriki 2024 Mar 28;35(1):78-82. Epub 2023 Nov 14 doi: 10.22365/jpsych.2023.026. PMID: 37982250
Roles of neuroimage in toxic encephalopathy induced by 1, 2-Dichloroethane.
Liu J, Zhang L, He B, Zhuang JH, Xu J, Huang LY, Peng H
Clin Neurol Neurosurg 2019 Sep;184:105398. Epub 2019 Jul 9 doi: 10.1016/j.clineuro.2019.105398. PMID: 31319235
Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes.
Eide PK, Vatnehol SAS, Emblem KE, Ringstad G
Sci Rep 2018 May 8;8(1):7194. doi: 10.1038/s41598-018-25666-4. PMID: 29740121Free PMC Article
Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis.
Zhang Y, Zabad R, Wei X, Metz L, Hill M, Mitchell J
Mult Scler 2007 Aug;13(7):880-3. Epub 2007 Apr 27 doi: 10.1177/1352458507076411. PMID: 17468444
Magnetization transfer ratio measurements of the brain in children with tuberous sclerosis complex.
Zikou A, Ioannidou MC, Tzoufi M, Astrakas L, Argyropoulou MI
Pediatr Radiol 2005 Nov;35(11):1071-4. Epub 2005 Jul 29 doi: 10.1007/s00247-005-1539-y. PMID: 16052334

Prognosis

Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Predicting motor outcome and death in term hypoxic-ischemic encephalopathy.
Martinez-Biarge M, Diez-Sebastian J, Kapellou O, Gindner D, Allsop JM, Rutherford MA, Cowan FM
Neurology 2011 Jun 14;76(24):2055-61. doi: 10.1212/WNL.0b013e31821f442d. PMID: 21670434Free PMC Article
Thalamic damage and long-term progression of disability in multiple sclerosis.
Rocca MA, Mesaros S, Pagani E, Sormani MP, Comi G, Filippi M
Radiology 2010 Nov;257(2):463-9. Epub 2010 Aug 19 doi: 10.1148/radiol.10100326. PMID: 20724544
Serial brain MRI and ultrasound findings: relation to gestational age, bilirubin level, neonatal neurologic status and neurodevelopmental outcome in infants at risk of kernicterus.
Gkoltsiou K, Tzoufi M, Counsell S, Rutherford M, Cowan F
Early Hum Dev 2008 Dec;84(12):829-38. Epub 2008 Oct 11 doi: 10.1016/j.earlhumdev.2008.09.008. PMID: 18851903
Intracranial ganglioglioma: clinicopathological and MRI findings in 16 patients.
Zhang D, Henning TD, Zou LG, Hu LB, Wen L, Feng XY, Dai SH, Wang WX, Sun QR, Zhang ZG
Clin Radiol 2008 Jan;63(1):80-91. Epub 2007 Nov 5 doi: 10.1016/j.crad.2007.06.010. PMID: 18068794

Clinical prediction guides

MRI abnormalities in Creutzfeldt-Jakob disease and other rapidly progressive dementia.
Manara R, Fragiacomo F, Ladogana A, Vaianella L, Camporese G, Zorzi G, Vicinanza S, Zanusso G, Pocchiari M, Cagnin A
J Neurol 2024 Jan;271(1):300-309. Epub 2023 Sep 12 doi: 10.1007/s00415-023-11962-1. PMID: 37698615Free PMC Article
Morphology and morphometry of the human early foetal brain: A three-dimensional analysis.
Takakuwa T, Shiraishi N, Terashima M, Yamanaka M, Okamoto I, Imai H, Ishizu K, Yamada S, Ishikawa A, Kanahashi T
J Anat 2021 Aug;239(2):498-516. Epub 2021 Mar 23 doi: 10.1111/joa.13433. PMID: 33754346Free PMC Article
Thalamic damage and long-term progression of disability in multiple sclerosis.
Rocca MA, Mesaros S, Pagani E, Sormani MP, Comi G, Filippi M
Radiology 2010 Nov;257(2):463-9. Epub 2010 Aug 19 doi: 10.1148/radiol.10100326. PMID: 20724544
Serial brain MRI and ultrasound findings: relation to gestational age, bilirubin level, neonatal neurologic status and neurodevelopmental outcome in infants at risk of kernicterus.
Gkoltsiou K, Tzoufi M, Counsell S, Rutherford M, Cowan F
Early Hum Dev 2008 Dec;84(12):829-38. Epub 2008 Oct 11 doi: 10.1016/j.earlhumdev.2008.09.008. PMID: 18851903
Functional imaging of brain responses to pain. A review and meta-analysis (2000).
Peyron R, Laurent B, García-Larrea L
Neurophysiol Clin 2000 Oct;30(5):263-88. doi: 10.1016/s0987-7053(00)00227-6. PMID: 11126640

Recent systematic reviews

Decreased T2 signal in the thalami may be a sign of lysosomal storage disease.
Autti T, Joensuu R, Aberg L
Neuroradiology 2007 Jul;49(7):571-8. Epub 2007 Mar 3 doi: 10.1007/s00234-007-0220-6. PMID: 17334752

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