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Abnormality of pineal physiology

MedGen UID:
868384
•Concept ID:
C4022778
•
Pathologic Function
HPO: HP:0012688

Definition

A functional abnormality of the pineal gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of pineal physiology

Professional guidelines

PubMed

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article
Role of melatonin in the pathophysiology of migraine: implications for treatment.
Vogler B, Rapoport AM, Tepper SJ, Sheftell F, Bigal ME
CNS Drugs 2006;20(5):343-50. doi: 10.2165/00023210-200620050-00001. PMID: 16696576
Epidemiology, etiology, and natural treatment of seasonal affective disorder.
Miller AL
Altern Med Rev 2005 Mar;10(1):5-13. PMID: 15771558

Recent clinical studies

Etiology

Melatonin and Epilepsy.
Vasileva Z
Folia Med (Plovdiv) 2021 Dec 31;63(6):827-833. doi: 10.3897/folmed.63.e58637. PMID: 35851222
Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.
Zhu HL, Shi XT, Xu XF, Zhou GX, Xiong YW, Yi SJ, Liu WB, Dai LM, Cao XL, Xu DX, Wang H
Redox Biol 2021 Apr;40:101854. Epub 2021 Jan 6 doi: 10.1016/j.redox.2021.101854. PMID: 33454563Free PMC Article
Melatonin and alcohol-related disorders.
Kurhaluk N, Tkachenko H
Chronobiol Int 2020 Jun;37(6):781-803. Epub 2020 May 18 doi: 10.1080/07420528.2020.1761372. PMID: 32419511
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531
The pineal gland from development to function.
Sapède D, Cau E
Curr Top Dev Biol 2013;106:171-215. doi: 10.1016/B978-0-12-416021-7.00005-5. PMID: 24290350

Diagnosis

Nomo1 deficiency causes autism-like behavior in zebrafish.
Zhang Q, Li F, Li T, Lin J, Jian J, Zhang Y, Chen X, Liu T, Gou S, Zhang Y, Liu X, Ji Y, Wang X, Li Q
EMBO Rep 2024 Feb;25(2):570-592. Epub 2024 Jan 22 doi: 10.1038/s44319-023-00036-y. PMID: 38253686Free PMC Article
Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article
Familial pineocytoma.
Gempt J, Ringel F, Oexle K, Delbridge C, Förschler A, Schlegel J, Meyer B, Schmidt-Graf F
Acta Neurochir (Wien) 2012 Aug;154(8):1413-6. Epub 2012 Jun 15 doi: 10.1007/s00701-012-1402-5. PMID: 22699425
Wilson disease.
Kitzberger R, Madl C, Ferenci P
Metab Brain Dis 2005 Dec;20(4):295-302. doi: 10.1007/s11011-005-7910-8. PMID: 16382340
The eye and sleep.
McNab AA
Clin Exp Ophthalmol 2005 Apr;33(2):117-25. doi: 10.1111/j.1442-9071.2005.00969.x. PMID: 15807817

Therapy

Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight.
Li Y, Hung SW, Zhang R, Man GC, Zhang T, Chung JP, Fang L, Wang CC
Nutrients 2022 Oct 1;14(19) doi: 10.3390/nu14194087. PMID: 36235740Free PMC Article
Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article
Melatonin and Epilepsy.
Vasileva Z
Folia Med (Plovdiv) 2021 Dec 31;63(6):827-833. doi: 10.3897/folmed.63.e58637. PMID: 35851222
The role of melatonin in Multiple Sclerosis.
Skarlis C, Anagnostouli M
Neurol Sci 2020 Apr;41(4):769-781. Epub 2019 Dec 16 doi: 10.1007/s10072-019-04137-2. PMID: 31845043
Melatonin as a chronobiotic.
Arendt J, Skene DJ
Sleep Med Rev 2005 Feb;9(1):25-39. doi: 10.1016/j.smrv.2004.05.002. PMID: 15649736

Prognosis

Melatonin and Epilepsy.
Vasileva Z
Folia Med (Plovdiv) 2021 Dec 31;63(6):827-833. doi: 10.3897/folmed.63.e58637. PMID: 35851222
Reduced pineal gland volume across the stages of schizophrenia.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M
Schizophr Res 2019 Apr;206:163-170. Epub 2018 Dec 5 doi: 10.1016/j.schres.2018.11.032. PMID: 30527931
Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways.
Anderson G, Jacob A, Bellivier F, Geoffroy PA
Curr Pharm Des 2016;22(8):987-1012. doi: 10.2174/1381612822666151214105314. PMID: 26654772
Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation.
Kang YJ, Bi WL, Dubuc AM, Martineau L, Ligon AH, Berkowitz AL, Aizer AA, Lee EQ, Ligon KL, Ramkissoon SH, Dunn IF
World Neurosurg 2016 Jan;85:96-105. Epub 2015 Jul 28 doi: 10.1016/j.wneu.2015.07.032. PMID: 26226092
Intracranial germ cell tumours. A review with special reference to endocrine manifestations.
Jorsal T, Rørth M
Acta Oncol 2012 Jan;51(1):3-9. doi: 10.3109/0284186X.2011.586000. PMID: 22150165

Clinical prediction guides

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.
Zhu HL, Shi XT, Xu XF, Zhou GX, Xiong YW, Yi SJ, Liu WB, Dai LM, Cao XL, Xu DX, Wang H
Redox Biol 2021 Apr;40:101854. Epub 2021 Jan 6 doi: 10.1016/j.redox.2021.101854. PMID: 33454563Free PMC Article
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531
Melatonin in autism spectrum disorders.
Rossignol DA, Frye RE
Curr Clin Pharmacol 2014;9(4):326-34. doi: 10.2174/15748847113086660072. PMID: 24050742
Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome.
Mahdi AA, Fatima G, Das SK, Verma NS
Indian J Biochem Biophys 2011 Apr;48(2):82-7. PMID: 21682138
Human pineal physiology and functional significance of melatonin.
Macchi MM, Bruce JN
Front Neuroendocrinol 2004 Sep-Dec;25(3-4):177-95. doi: 10.1016/j.yfrne.2004.08.001. PMID: 15589268

Recent systematic reviews

Pineal gland and schizophrenia: A systematic review and meta-analysis.
Bastos MAV Jr, Oliveira Bastos PRH, Portella RB, Soares LFG, Conde RB, Rodrigues PMF Jr, Lucchetti G
Psychoneuroendocrinology 2019 Jun;104:100-114. Epub 2019 Feb 25 doi: 10.1016/j.psyneuen.2019.02.024. PMID: 30831343
Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment.
Phillips L, Appleton RE
Dev Med Child Neurol 2004 Nov;46(11):771-5. doi: 10.1017/s001216220400132x. PMID: 15540639

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