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Abnormal pineal volume

MedGen UID:
868387
•Concept ID:
C4022781
•
Anatomical Abnormality
HPO: HP:0012684

Definition

An abnormal increase or decrease in the quantity of three-dimensional space taken up by the pineal gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal pineal volume

Professional guidelines

PubMed

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article

Recent clinical studies

Etiology

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Potential contribution of pineal atrophy and pineal cysts toward vulnerability and clinical characteristics of psychosis.
Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
Neuroimage Clin 2021;32:102805. Epub 2021 Aug 25 doi: 10.1016/j.nicl.2021.102805. PMID: 34461434Free PMC Article
Pineal cysts: Does anyone need long-term follow up?
Tanaka T, Arnold L, Gabriela Mazuru D, Golzy M, Carr SB, Litofsky NS
J Clin Neurosci 2021 Jan;83:146-151. Epub 2020 Nov 30 doi: 10.1016/j.jocn.2020.10.051. PMID: 33272885
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531
Reduced pineal gland volume across the stages of schizophrenia.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M
Schizophr Res 2019 Apr;206:163-170. Epub 2018 Dec 5 doi: 10.1016/j.schres.2018.11.032. PMID: 30527931

Diagnosis

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article
Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index.
Mazhar K, Olson DM, Atem FD, Stutzman SE, Moreno J, Venkatachalam A, Aiyagari V
Clin Neurol Neurosurg 2021 Jan;200:106410. Epub 2020 Dec 5 doi: 10.1016/j.clineuro.2020.106410. PMID: 33341651
Pineal cysts: Does anyone need long-term follow up?
Tanaka T, Arnold L, Gabriela Mazuru D, Golzy M, Carr SB, Litofsky NS
J Clin Neurosci 2021 Jan;83:146-151. Epub 2020 Nov 30 doi: 10.1016/j.jocn.2020.10.051. PMID: 33272885
Pediatric central nervous system germ cell tumors: a review.
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Therapy

Role of Melatonin in the Management of Sleep and Circadian Disorders in the Context of Psychiatric Illness.
Moon E, Kim K, Partonen T, Linnaranta O
Curr Psychiatry Rep 2022 Nov;24(11):623-634. Epub 2022 Oct 13 doi: 10.1007/s11920-022-01369-6. PMID: 36227449Free PMC Article
Epilepsy in patients with pineal gland cyst.
Bosnjak J, Butkovic SS, Miskov S, Coric L, Jadrijevic-Tomas A, Mejaski-Bosnjak V
Clin Neurol Neurosurg 2018 Feb;165:72-75. Epub 2018 Jan 4 doi: 10.1016/j.clineuro.2017.12.025. PMID: 29324398
Radiation-induced tumor after stereotactic radiosurgery for an arteriovenous malformation: case report.
Berman EL, Eade TN, Brown D, Weaver M, Glass J, Zorman G, Feigenberg SJ
Neurosurgery 2007 Nov;61(5):E1099; discussion E1099. doi: 10.1227/01.neu.0000303207.92617.4e. PMID: 18091259

Prognosis

Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index.
Mazhar K, Olson DM, Atem FD, Stutzman SE, Moreno J, Venkatachalam A, Aiyagari V
Clin Neurol Neurosurg 2021 Jan;200:106410. Epub 2020 Dec 5 doi: 10.1016/j.clineuro.2020.106410. PMID: 33341651
Pineal cysts: Does anyone need long-term follow up?
Tanaka T, Arnold L, Gabriela Mazuru D, Golzy M, Carr SB, Litofsky NS
J Clin Neurosci 2021 Jan;83:146-151. Epub 2020 Nov 30 doi: 10.1016/j.jocn.2020.10.051. PMID: 33272885
Reduced pineal gland volume across the stages of schizophrenia.
Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M
Schizophr Res 2019 Apr;206:163-170. Epub 2018 Dec 5 doi: 10.1016/j.schres.2018.11.032. PMID: 30527931
Epilepsy in patients with pineal gland cyst.
Bosnjak J, Butkovic SS, Miskov S, Coric L, Jadrijevic-Tomas A, Mejaski-Bosnjak V
Clin Neurol Neurosurg 2018 Feb;165:72-75. Epub 2018 Jan 4 doi: 10.1016/j.clineuro.2017.12.025. PMID: 29324398
Pediatric central nervous system germ cell tumors: a review.
Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

Clinical prediction guides

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Potential contribution of pineal atrophy and pineal cysts toward vulnerability and clinical characteristics of psychosis.
Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
Neuroimage Clin 2021;32:102805. Epub 2021 Aug 25 doi: 10.1016/j.nicl.2021.102805. PMID: 34461434Free PMC Article
Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index.
Mazhar K, Olson DM, Atem FD, Stutzman SE, Moreno J, Venkatachalam A, Aiyagari V
Clin Neurol Neurosurg 2021 Jan;200:106410. Epub 2020 Dec 5 doi: 10.1016/j.clineuro.2020.106410. PMID: 33341651
Pineal cysts: Does anyone need long-term follow up?
Tanaka T, Arnold L, Gabriela Mazuru D, Golzy M, Carr SB, Litofsky NS
J Clin Neurosci 2021 Jan;83:146-151. Epub 2020 Nov 30 doi: 10.1016/j.jocn.2020.10.051. PMID: 33272885
Pineal gland abnormality in major depressive disorder.
Zhao W, Zhu DM, Zhang Y, Zhang C, Wang Y, Yang Y, Bai Y, Zhu J, Yu Y
Psychiatry Res Neuroimaging 2019 Jul 30;289:13-17. Epub 2019 May 15 doi: 10.1016/j.pscychresns.2019.05.004. PMID: 31121531

Recent systematic reviews

Prevalence of incidental intracranial findings on magnetic resonance imaging: a systematic review and meta-analysis.
Sunny DE, Amoo M, Al Breiki M, Teng EDW, Henry J, Javadpour M
Acta Neurochir (Wien) 2022 Oct;164(10):2751-2765. Epub 2022 May 8 doi: 10.1007/s00701-022-05225-7. PMID: 35525892Free PMC Article
Pineal gland and schizophrenia: A systematic review and meta-analysis.
Bastos MAV Jr, Oliveira Bastos PRH, Portella RB, Soares LFG, Conde RB, Rodrigues PMF Jr, Lucchetti G
Psychoneuroendocrinology 2019 Jun;104:100-114. Epub 2019 Feb 25 doi: 10.1016/j.psyneuen.2019.02.024. PMID: 30831343

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