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Heavy proteinuria

MedGen UID:
868436
•Concept ID:
C4022830
•
Finding
Synonym: Severly high blood protein levels
 
HPO: HP:0012597

Definition

Severely increased levels of protein in the urine (1000-3000 mg per day in adults). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeavy proteinuria

Professional guidelines

PubMed

Diagnosis and Management of Nephrotic Syndrome in Adults.
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article
VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management.
Izzedine H, Massard C, Spano JP, Goldwasser F, Khayat D, Soria JC
Eur J Cancer 2010 Jan;46(2):439-48. Epub 2009 Dec 16 doi: 10.1016/j.ejca.2009.11.001. PMID: 20006922

Recent clinical studies

Etiology

Renal amyloidosis: a new time for a complete diagnosis.
Feitosa VA, Neves PDMM, Jorge LB, Noronha IL, Onuchic LF
Braz J Med Biol Res 2022;55:e12284. Epub 2022 Oct 3 doi: 10.1590/1414-431X2022e12284. PMID: 36197414Free PMC Article
Renal amyloidosis: an update on diagnosis and pathogenesis.
Gupta N, Kaur H, Wajid S
Protoplasma 2020 Sep;257(5):1259-1276. Epub 2020 May 24 doi: 10.1007/s00709-020-01513-0. PMID: 32447467
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M
Int J Mol Sci 2020 Jan 14;21(2) doi: 10.3390/ijms21020525. PMID: 31947692Free PMC Article
Nephrotic syndrome in adults.
Mahalingasivam V, Booth J, Sheaff M, Yaqoob M
Acute Med 2018;17(1):36-43. PMID: 29589604
Congenital nephrotic syndrome.
Jalanko H
Pediatr Nephrol 2009 Nov;24(11):2121-8. Epub 2007 Oct 30 doi: 10.1007/s00467-007-0633-9. PMID: 17968594Free PMC Article

Diagnosis

Nephrotic Syndrome.
Rodriguez-Ballestas E, Reid-Adam J
Pediatr Rev 2022 Feb 1;43(2):87-99. doi: 10.1542/pir.2020-001230. PMID: 35102405
Renal amyloidosis: an update on diagnosis and pathogenesis.
Gupta N, Kaur H, Wajid S
Protoplasma 2020 Sep;257(5):1259-1276. Epub 2020 May 24 doi: 10.1007/s00709-020-01513-0. PMID: 32447467
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M
Int J Mol Sci 2020 Jan 14;21(2) doi: 10.3390/ijms21020525. PMID: 31947692Free PMC Article
Diagnosis and Management of Nephrotic Syndrome in Adults.
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article

Therapy

Multidisciplinary approach to lupus nephritis: Clinical pearls, pitfalls, and positioning of newly-approved agents.
Fanouriakis A, Bertsias G, Liapis G, Marinaki S, Papagianni A, Stangou M, Garyfallos A, Lionaki S, Tektonidou MG, Boletis JN, Boumpas DT
Lupus 2023 Sep;32(10):1155-1163. Epub 2023 Jul 27 doi: 10.1177/09612033231191944. PMID: 37499240
Renal amyloidosis: a new time for a complete diagnosis.
Feitosa VA, Neves PDMM, Jorge LB, Noronha IL, Onuchic LF
Braz J Med Biol Res 2022;55:e12284. Epub 2022 Oct 3 doi: 10.1590/1414-431X2022e12284. PMID: 36197414Free PMC Article
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M
Int J Mol Sci 2020 Jan 14;21(2) doi: 10.3390/ijms21020525. PMID: 31947692Free PMC Article
Diagnosis and Management of Nephrotic Syndrome in Adults.
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
Congenital nephrotic syndrome.
Jalanko H
Pediatr Nephrol 2009 Nov;24(11):2121-8. Epub 2007 Oct 30 doi: 10.1007/s00467-007-0633-9. PMID: 17968594Free PMC Article

Prognosis

Renal amyloidosis: a new time for a complete diagnosis.
Feitosa VA, Neves PDMM, Jorge LB, Noronha IL, Onuchic LF
Braz J Med Biol Res 2022;55:e12284. Epub 2022 Oct 3 doi: 10.1590/1414-431X2022e12284. PMID: 36197414Free PMC Article
Nephrotic Syndrome.
Rodriguez-Ballestas E, Reid-Adam J
Pediatr Rev 2022 Feb 1;43(2):87-99. doi: 10.1542/pir.2020-001230. PMID: 35102405
Renal amyloidosis: an update on diagnosis and pathogenesis.
Gupta N, Kaur H, Wajid S
Protoplasma 2020 Sep;257(5):1259-1276. Epub 2020 May 24 doi: 10.1007/s00709-020-01513-0. PMID: 32447467
Diagnosis and Management of Nephrotic Syndrome in Adults.
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article

Clinical prediction guides

The epidemiology of primary FSGS including cluster analysis over a 20-year period.
McDonnell T, Storrar J, Chinnadurai R, Heal C, Chrysochou C, Ritchie J, Rainone F, Poulikakos D, Kalra P, Sinha S
BMC Nephrol 2023 Dec 10;24(1):365. doi: 10.1186/s12882-023-03405-w. PMID: 38072955Free PMC Article
Clinical manifestations, prognosis, and treat-to-target assessment of pediatric lupus nephritis.
Qiu S, Zhang H, Yu S, Yang Q, Zhang G, Yang H, Li Q, Wang M
Pediatr Nephrol 2022 Feb;37(2):367-376. Epub 2021 Aug 11 doi: 10.1007/s00467-021-05164-y. PMID: 34379208Free PMC Article
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M
Int J Mol Sci 2020 Jan 14;21(2) doi: 10.3390/ijms21020525. PMID: 31947692Free PMC Article
Diagnosis and classification of IgA nephropathy.
Yu HH, Chiang BL
Autoimmun Rev 2014 Apr-May;13(4-5):556-9. Epub 2014 Jan 13 doi: 10.1016/j.autrev.2014.01.030. PMID: 24434362
Immunopathogenesis of idiopathic nephrotic syndrome with relapse.
Sahali D, Sendeyo K, Mangier M, Audard V, Zhang SY, Lang P, Ollero M, Pawlak A
Semin Immunopathol 2014 Jul;36(4):421-9. Epub 2014 Jan 9 doi: 10.1007/s00281-013-0415-3. PMID: 24402710Free PMC Article

Recent systematic reviews

Preoperative proteinuria may be a risk factor for postoperative acute kidney injury：a meta-analysis.
Huang DD, Li YY, Fan Z, Wu YG
Ren Fail 2021 Dec;43(1):958-967. doi: 10.1080/0886022X.2021.1940201. PMID: 34148499Free PMC Article
Minimal mesangial lupus nephritis: a systematic review.
Mok CC, Cheung TT, Lo WH
Scand J Rheumatol 2010 May;39(3):181-9. doi: 10.3109/03009740903456300. PMID: 20166847

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