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Reduced thyroxin-binding globulin

MedGen UID:
868478
•Concept ID:
C4022872
•
Finding
HPO: HP:0012509

Definition

An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced thyroxin-binding globulin

Professional guidelines

PubMed

Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
Eirís-Puñal J, Del Río-Garma M, Del Río-Garma MC, Lojo-Rocamonde S, Novo-Rodríguez I, Castro-Gago M
Epilepsia 1999 Dec;40(12):1761-6. doi: 10.1111/j.1528-1157.1999.tb01595.x. PMID: 10612341
Neonatal screening for congenital hypothyroidism by measurement of plasma thyroxine and thyroid stimulating hormone concentrations.
Griffiths KD, Virdi NK, Rayner PH, Green A
Br Med J (Clin Res Ed) 1985 Jul 13;291(6488):117-20. doi: 10.1136/bmj.291.6488.117. PMID: 3926078Free PMC Article
Evaluation of three thyroid-function screening tests for detecting neonatal hypothyroidism.
Walfish PG
Lancet 1976 Jun 5;1(7971):1208-10. doi: 10.1016/s0140-6736(76)92159-0. PMID: 58257

Recent clinical studies

Etiology

Thyroid physiology in pregnancy.
Moleti M, Trimarchi F, Vermiglio F
Endocr Pract 2014 Jun;20(6):589-96. doi: 10.4158/EP13341.RA. PMID: 24449667
Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria.
Das SC, Mohammed AZ, Al-Hassan S, Otokwula AA, Isichei UP
Indian J Med Res 2006 Nov;124(5):535-44. PMID: 17213522
Thyroid function and postmenopause.
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea.
Dominguez CE, Laughlin GA, Nelson JC, Yen SS
Fertil Steril 1997 Dec;68(6):992-6. doi: 10.1016/s0015-0282(97)00393-2. PMID: 9418685
Differential hormone-binding characteristics of thyroxine-binding globulin in hepatocellular carcinoma and cirrhosis.
Hutchinson WL, Johnson PJ, White YS, Williams R
J Hepatol 1989 Sep;9(2):265-71. doi: 10.1016/0168-8278(89)90062-7. PMID: 2553799

Diagnosis

Levothyroxine Therapy in Thyrodectomized Patients.
Miccoli P, Materazzi G, Rossi L
Front Endocrinol (Lausanne) 2020;11:626268. Epub 2021 Jan 29 doi: 10.3389/fendo.2020.626268. PMID: 33584551Free PMC Article
Thyroid function and postmenopause.
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Human immunodeficiency virus infection and the thyroid.
Koutkia P, Mylonakis E, Levin RM
Thyroid 2002 Jul;12(7):577-82. doi: 10.1089/105072502320288429. PMID: 12193301
Differential hormone-binding characteristics of thyroxine-binding globulin in hepatocellular carcinoma and cirrhosis.
Hutchinson WL, Johnson PJ, White YS, Williams R
J Hepatol 1989 Sep;9(2):265-71. doi: 10.1016/0168-8278(89)90062-7. PMID: 2553799
Thyroxine binding globulin and thyroid function tests in patients with hepatocellular carcinoma.
Kalk WJ, Kew MC, Danilewitz MD, Jacks F, van der Walt LA, Levin J
Hepatology 1982 Jan-Feb;2(1):72-6. doi: 10.1002/hep.1840020112. PMID: 6274780

Therapy

Levothyroxine Therapy in Thyrodectomized Patients.
Miccoli P, Materazzi G, Rossi L
Front Endocrinol (Lausanne) 2020;11:626268. Epub 2021 Jan 29 doi: 10.3389/fendo.2020.626268. PMID: 33584551Free PMC Article
Thyroid physiology in pregnancy.
Moleti M, Trimarchi F, Vermiglio F
Endocr Pract 2014 Jun;20(6):589-96. doi: 10.4158/EP13341.RA. PMID: 24449667
Thyroid function and postmenopause.
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Human immunodeficiency virus infection and the thyroid.
Koutkia P, Mylonakis E, Levin RM
Thyroid 2002 Jul;12(7):577-82. doi: 10.1089/105072502320288429. PMID: 12193301
Thyroid function in patients with chronic renal failure.
Lim VS
Am J Kidney Dis 2001 Oct;38(4 Suppl 1):S80-4. doi: 10.1053/ajkd.2001.27410. PMID: 11576928

Prognosis

A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.
Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE, Dumitrescu AM, Refetoff S
J Clin Endocrinol Metab 2015 Jan;100(1):E173-81. doi: 10.1210/jc.2014-3490. PMID: 25361180Free PMC Article
The stressful condition as a nutritionally dependent adaptive dichotomy.
Ingenbleek Y, Bernstein L
Nutrition 1999 Apr;15(4):305-20. doi: 10.1016/s0899-9007(99)00009-x. PMID: 10319365
Long-term observation of the hypothalamic-pituitary-thyroid (HPT) axis in alcohol-dependent patients.
Heinz A, Bauer M, Kuhn S, Krüger F, Gräf KJ, Rommelspacher H, Schmidt LG
Acta Psychiatr Scand 1996 Jun;93(6):470-6. doi: 10.1111/j.1600-0447.1996.tb10679.x. PMID: 8831864
Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome".
Bratusch-Marrain P, Vierhapper H, Grubeck-Loebenstein B, Waldhäusl W, Kleinberger G
Endokrinologie 1982 Oct;80(2):207-12. PMID: 6819131

Clinical prediction guides

Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis.
Liu H, Hallauer Hastings M, Kitchen R, Xiao C, Baldovino Guerra JR, Kuznetsov A, Rosenzweig A
Arterioscler Thromb Vasc Biol 2023 Feb;43(2):330-349. Epub 2022 Dec 1 doi: 10.1161/ATVBAHA.122.318138. PMID: 36453275
A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.
Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE, Dumitrescu AM, Refetoff S
J Clin Endocrinol Metab 2015 Jan;100(1):E173-81. doi: 10.1210/jc.2014-3490. PMID: 25361180Free PMC Article
Linkage between the hormone binding site and the reactive center loop of thyroxine binding globulin.
Suda SA, Gettins PG, Patston PA
Arch Biochem Biophys 2000 Dec 1;384(1):31-6. doi: 10.1006/abbi.2000.2110. PMID: 11147833
Differential hormone-binding characteristics of thyroxine-binding globulin in hepatocellular carcinoma and cirrhosis.
Hutchinson WL, Johnson PJ, White YS, Williams R
J Hepatol 1989 Sep;9(2):265-71. doi: 10.1016/0168-8278(89)90062-7. PMID: 2553799
Hypothalamic-pituitary-thyroid axis in acromegaly.
Carmina E, Rosato F, Pirronello S, Jannì A
J Endocrinol Invest 1983 Aug;6(4):263-6. doi: 10.1007/BF03347587. PMID: 6417217

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