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Reduced thyroxin-binding globulin

MedGen UID:
868478
Concept ID:
C4022872
Finding
HPO: HP:0012509

Definition

An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced thyroxin-binding globulin

Professional guidelines

PubMed

Bratel T, Wennlund A, Carlström K
Respir Med 2000 Dec;94(12):1221-8. doi: 10.1053/rmed.2000.0953. PMID: 11192959
Eirís-Puñal J, Del Río-Garma M, Del Río-Garma MC, Lojo-Rocamonde S, Novo-Rodríguez I, Castro-Gago M
Epilepsia 1999 Dec;40(12):1761-6. doi: 10.1111/j.1528-1157.1999.tb01595.x. PMID: 10612341
Walfish PG
Lancet 1976 Jun 5;1(7971):1208-10. doi: 10.1016/s0140-6736(76)92159-0. PMID: 58257

Recent clinical studies

Etiology

Moleti M, Trimarchi F, Vermiglio F
Endocr Pract 2014 Jun;20(6):589-96. doi: 10.4158/EP13341.RA. PMID: 24449667
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Dominguez CE, Laughlin GA, Nelson JC, Yen SS
Fertil Steril 1997 Dec;68(6):992-6. doi: 10.1016/s0015-0282(97)00393-2. PMID: 9418685
Hutchinson WL, Johnson PJ, White YS, Williams R
J Hepatol 1989 Sep;9(2):265-71. doi: 10.1016/0168-8278(89)90062-7. PMID: 2553799
Scriba PC, Bauer M, Emmert D, Fateh-Moghadam A, Hofmann GG, Horn K, Pickardt CR
Acta Endocrinol (Copenh) 1979 Aug;91(4):629-43. doi: 10.1530/acta.0.0910629. PMID: 115194

Diagnosis

Miccoli P, Materazzi G, Rossi L
Front Endocrinol (Lausanne) 2020;11:626268. Epub 2021 Jan 29 doi: 10.3389/fendo.2020.626268. PMID: 33584551Free PMC Article
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Koutkia P, Mylonakis E, Levin RM
Thyroid 2002 Jul;12(7):577-82. doi: 10.1089/105072502320288429. PMID: 12193301
Macchia PE, Harrison HH, Scherberg NH, Sunthornthepfvarakul T, Jaeken J, Refetoff S
J Clin Endocrinol Metab 1995 Dec;80(12):3744-9. doi: 10.1210/jcem.80.12.8530628. PMID: 8530628
Kalk WJ, Kew MC, Danilewitz MD, Jacks F, van der Walt LA, Levin J
Hepatology 1982 Jan-Feb;2(1):72-6. doi: 10.1002/hep.1840020112. PMID: 6274780

Therapy

Miccoli P, Materazzi G, Rossi L
Front Endocrinol (Lausanne) 2020;11:626268. Epub 2021 Jan 29 doi: 10.3389/fendo.2020.626268. PMID: 33584551Free PMC Article
Moleti M, Trimarchi F, Vermiglio F
Endocr Pract 2014 Jun;20(6):589-96. doi: 10.4158/EP13341.RA. PMID: 24449667
Schindler AE
Gynecol Endocrinol 2003 Feb;17(1):79-85. PMID: 12724022
Koutkia P, Mylonakis E, Levin RM
Thyroid 2002 Jul;12(7):577-82. doi: 10.1089/105072502320288429. PMID: 12193301
Lim VS
Am J Kidney Dis 2001 Oct;38(4 Suppl 1):S80-4. doi: 10.1053/ajkd.2001.27410. PMID: 11576928

Prognosis

Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE, Dumitrescu AM, Refetoff S
J Clin Endocrinol Metab 2015 Jan;100(1):E173-81. doi: 10.1210/jc.2014-3490. PMID: 25361180Free PMC Article
Ingenbleek Y, Bernstein L
Nutrition 1999 Apr;15(4):305-20. doi: 10.1016/s0899-9007(99)00009-x. PMID: 10319365
Heinz A, Bauer M, Kuhn S, Krüger F, Gräf KJ, Rommelspacher H, Schmidt LG
Acta Psychiatr Scand 1996 Jun;93(6):470-6. doi: 10.1111/j.1600-0447.1996.tb10679.x. PMID: 8831864
Bratusch-Marrain P, Vierhapper H, Grubeck-Loebenstein B, Waldhäusl W, Kleinberger G
Endokrinologie 1982 Oct;80(2):207-12. PMID: 6819131

Clinical prediction guides

Suda SA, Gettins PG, Patston PA
Arch Biochem Biophys 2000 Dec 1;384(1):31-6. doi: 10.1006/abbi.2000.2110. PMID: 11147833
Hutchinson WL, Johnson PJ, White YS, Williams R
J Hepatol 1989 Sep;9(2):265-71. doi: 10.1016/0168-8278(89)90062-7. PMID: 2553799
Murata Y, Refetoff S, Sarne DH, Dick M, Watson F
J Endocrinol Invest 1985 Jun;8(3):225-32. doi: 10.1007/BF03348482. PMID: 3928734
Carmina E, Rosato F, Pirronello S, Jannì A
J Endocrinol Invest 1983 Aug;6(4):263-6. doi: 10.1007/BF03347587. PMID: 6417217
Bernutz C, Hänsle WO, Horn K, Pickardt CR, Scriba PC, Fink E, Kolb H, Tschesche H
Acta Endocrinol (Copenh) 1979 Oct;92(2):370-84. doi: 10.1530/acta.0.0920370. PMID: 115200

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