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Abnormal hypothalamus physiology

MedGen UID:
868569
Concept ID:
C4022968
Pathologic Function
HPO: HP:0012285

Definition

An abnormal functionality of the hypothalamus. [from HPO]

Professional guidelines

PubMed

Dunlop BW, Wong A
Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 8;89:361-379. Epub 2018 Oct 17 doi: 10.1016/j.pnpbp.2018.10.010. PMID: 30342071
Hoffmann J, May A
Lancet Neurol 2018 Jan;17(1):75-83. Epub 2017 Nov 23 doi: 10.1016/S1474-4422(17)30405-2. PMID: 29174963
Klein DA, Emerick JE, Sylvester JE, Vogt KS
Am Fam Physician 2017 Nov 1;96(9):590-599. PMID: 29094880

Recent clinical studies

Etiology

Prete A, Auchus RJ, Ross RJ
Eur J Endocrinol 2021 Nov 30;186(1):R1-R14. doi: 10.1530/EJE-21-0794. PMID: 34735372Free PMC Article
Dunlop BW, Wong A
Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 8;89:361-379. Epub 2018 Oct 17 doi: 10.1016/j.pnpbp.2018.10.010. PMID: 30342071
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Demarest SP, Gill RS, Adler RA
Endocr Pract 2015 Feb;21(2):190-8. doi: 10.4158/EP14339.RA. PMID: 25536970
Groth KA, Skakkebæk A, Høst C, Gravholt CH, Bojesen A
J Clin Endocrinol Metab 2013 Jan;98(1):20-30. Epub 2012 Nov 1 doi: 10.1210/jc.2012-2382. PMID: 23118429

Diagnosis

Munro MG, Balen AH, Cho S, Critchley HOD, Díaz I, Ferriani R, Henry L, Edgar Mocanu, van der Spuy ZM; FIGO Committee on Menstrual Disorders and Related Health Impacts, and FIGO Committee on Reproductive Medicine, Endocrinology, and Infertility
Fertil Steril 2022 Oct;118(4):768-786. Epub 2022 Aug 19 doi: 10.1016/j.fertnstert.2022.07.009. PMID: 35995633
Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS
Nat Rev Dis Primers 2019 Aug 8;5(1):54. doi: 10.1038/s41572-019-0103-2. PMID: 31395885
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339
Groth KA, Skakkebæk A, Høst C, Gravholt CH, Bojesen A
J Clin Endocrinol Metab 2013 Jan;98(1):20-30. Epub 2012 Nov 1 doi: 10.1210/jc.2012-2382. PMID: 23118429

Therapy

Manfredi-Lozano M, Leysen V, Adamo M, Paiva I, Rovera R, Pignat JM, Timzoura FE, Candlish M, Eddarkaoui S, Malone SA, Silva MSB, Trova S, Imbernon M, Decoster L, Cotellessa L, Tena-Sempere M, Claret M, Paoloni-Giacobino A, Plassard D, Paccou E, Vionnet N, Acierno J, Maceski AM, Lutti A, Pfrieger F, Rasika S, Santoni F, Boehm U, Ciofi P, Buée L, Haddjeri N, Boutillier AL, Kuhle J, Messina A, Draganski B, Giacobini P, Pitteloud N, Prevot V
Science 2022 Sep 2;377(6610):eabq4515. doi: 10.1126/science.abq4515. PMID: 36048943Free PMC Article
Prete A, Auchus RJ, Ross RJ
Eur J Endocrinol 2021 Nov 30;186(1):R1-R14. doi: 10.1530/EJE-21-0794. PMID: 34735372Free PMC Article
Rachdaoui N, Sarkar DK
Alcohol Res 2017;38(2):255-276. PMID: 28988577Free PMC Article
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Demarest SP, Gill RS, Adler RA
Endocr Pract 2015 Feb;21(2):190-8. doi: 10.4158/EP14339.RA. PMID: 25536970

Prognosis

Rossetti CL, Cazarin J, Hecht F, Beltrão FEL, Ferreira ACF, Fortunato RS, Ramos HE, de Carvalho DP
Front Endocrinol (Lausanne) 2022;13:1041676. Epub 2022 Dec 19 doi: 10.3389/fendo.2022.1041676. PMID: 36601011Free PMC Article
Sabatino ME, Grondona E, De Paul AL
Front Endocrinol (Lausanne) 2022;13:924942. Epub 2022 Jun 28 doi: 10.3389/fendo.2022.924942. PMID: 35837315Free PMC Article
Höybye C, Tauber M
J Clin Endocrinol Metab 2022 May 17;107(6):1698-1705. doi: 10.1210/clinem/dgac082. PMID: 35150573Free PMC Article
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339
Oskouian RJ, Samii A, Laws ERJ Jr
Front Horm Res 2006;34:105-126. doi: 10.1159/000091578. PMID: 16474218

Clinical prediction guides

Sabatino ME, Grondona E, De Paul AL
Front Endocrinol (Lausanne) 2022;13:924942. Epub 2022 Jun 28 doi: 10.3389/fendo.2022.924942. PMID: 35837315Free PMC Article
Patel KP, Katsurada K, Zheng H
Circ Res 2022 May 13;130(10):1601-1617. Epub 2022 May 12 doi: 10.1161/CIRCRESAHA.122.319989. PMID: 35549375Free PMC Article
Liu M, He E, Fu X, Gong S, Han Y, Deng F
J Affect Disord 2022 Apr 1;302:324-331. Epub 2022 Jan 13 doi: 10.1016/j.jad.2022.01.057. PMID: 35032508
Bernstein HG, Keilhoff G, Steiner J
Handb Clin Neurol 2021;182:107-120. doi: 10.1016/B978-0-12-819973-2.00008-3. PMID: 34266587
Tauber M, Hoybye C
Lancet Diabetes Endocrinol 2021 Apr;9(4):235-246. Epub 2021 Feb 26 doi: 10.1016/S2213-8587(21)00002-4. PMID: 33647242

Recent systematic reviews

Klimes-Dougan B, Papke V, Carosella KA, Wiglesworth A, Mirza SA, Espensen-Sturges TD, Meester C
Neurosci Biobehav Rev 2022 Apr;135:104528. Epub 2022 Jan 11 doi: 10.1016/j.neubiorev.2022.104528. PMID: 35031342
Çalışkan E, Şahin MN, Güldağ MA
Yale J Biol Med 2021 Dec;94(4):623-635. Epub 2021 Dec 29 PMID: 34970101Free PMC Article
Juruena MF, Bocharova M, Agustini B, Young AH
J Affect Disord 2018 Jun;233:45-67. Epub 2017 Oct 6 doi: 10.1016/j.jad.2017.09.052. PMID: 29150144
Esposito D, Trimpou P, Giugliano D, Dehlin M, Ragnarsson O
Pituitary 2017 Oct;20(5):594-601. doi: 10.1007/s11102-017-0811-0. PMID: 28540625Free PMC Article
Belvederi Murri M, Prestia D, Mondelli V, Pariante C, Patti S, Olivieri B, Arzani C, Masotti M, Respino M, Antonioli M, Vassallo L, Serafini G, Perna G, Pompili M, Amore M
Psychoneuroendocrinology 2016 Jan;63:327-42. Epub 2015 Oct 21 doi: 10.1016/j.psyneuen.2015.10.014. PMID: 26547798

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