U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of von Willebrand factor

MedGen UID:
868623
Concept ID:
C4023023
Anatomical Abnormality
HPO: HP:0012146

Definition

Decreased quantity or activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces. [from HPO]

Professional guidelines

PubMed

Castaman G, Rodeghiero F
Expert Rev Hematol 2011 Feb;4(1):95-106. doi: 10.1586/ehm.11.1. PMID: 21322782
Hambleton J
Semin Hematol 2001 Oct;38(4 Suppl 9):7-10. doi: 10.1016/s0037-1963(01)90131-3. PMID: 11685720
Castaman G, Rodeghiero F
Drugs 1995 Oct;50(4):602-14. doi: 10.2165/00003495-199550040-00003. PMID: 8536549

Recent clinical studies

Etiology

Saragosti E, Fattal-Valevski A, Levin D, Hausman-Kedem M, Constantini S, Mecica N, Zarour S, Roth J
Childs Nerv Syst 2023 Apr;39(4):849-856. Epub 2023 Feb 27 doi: 10.1007/s00381-023-05888-2. PMID: 36847963
Comerford C, Glavey S, Quinn J, O'Sullivan JM
J Thromb Haemost 2022 Aug;20(8):1766-1777. Epub 2022 Jun 23 doi: 10.1111/jth.15773. PMID: 35644028Free PMC Article
Warkentin TE, Kaatz S
Thromb Res 2020 Dec;196:38-51. Epub 2020 Aug 10 doi: 10.1016/j.thromres.2020.08.017. PMID: 32841919Free PMC Article
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura
J Thromb Haemost 2017 Feb;15(2):312-322. Epub 2017 Jan 30 doi: 10.1111/jth.13571. PMID: 27868334
Lämmle B, Kremer Hovinga JA, Alberio L
J Thromb Haemost 2005 Aug;3(8):1663-75. doi: 10.1111/j.1538-7836.2005.01425.x. PMID: 16102032

Diagnosis

Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, Yagi H, Ogawa Y, Sakai K, Miyata T, Morishita E, Fujimura Y; For TTP group of Blood Coagulation Abnormalities Research Study Team, Research on Rare and Intractable diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan
Int J Hematol 2023 Nov;118(5):529-546. Epub 2023 Sep 10 doi: 10.1007/s12185-023-03657-0. PMID: 37689812Free PMC Article
Saragosti E, Fattal-Valevski A, Levin D, Hausman-Kedem M, Constantini S, Mecica N, Zarour S, Roth J
Childs Nerv Syst 2023 Apr;39(4):849-856. Epub 2023 Feb 27 doi: 10.1007/s00381-023-05888-2. PMID: 36847963
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Thachil J, Warkentin TE
Br J Haematol 2017 Apr;177(1):27-38. Epub 2016 Dec 16 doi: 10.1111/bjh.14482. PMID: 27982413
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H; International Working Group for Thrombotic Thrombocytopenic Purpura
J Thromb Haemost 2017 Feb;15(2):312-322. Epub 2017 Jan 30 doi: 10.1111/jth.13571. PMID: 27868334

Therapy

Chowdary P
Exp Physiol 2022 Jul;107(7):749-758. Epub 2022 Jun 22 doi: 10.1113/EP089404. PMID: 35733235Free PMC Article
Comerford C, Glavey S, Quinn J, O'Sullivan JM
J Thromb Haemost 2022 Aug;20(8):1766-1777. Epub 2022 Jun 23 doi: 10.1111/jth.15773. PMID: 35644028Free PMC Article
Warkentin TE, Kaatz S
Thromb Res 2020 Dec;196:38-51. Epub 2020 Aug 10 doi: 10.1016/j.thromres.2020.08.017. PMID: 32841919Free PMC Article
Kumar R, Vidaurre J, Gedela S
Pediatr Neurol 2019 Sep;98:25-30. Epub 2019 May 2 doi: 10.1016/j.pediatrneurol.2019.04.019. PMID: 31201069
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390

Prognosis

Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Warkentin TE, Kaatz S
Thromb Res 2020 Dec;196:38-51. Epub 2020 Aug 10 doi: 10.1016/j.thromres.2020.08.017. PMID: 32841919Free PMC Article
Ding WY, Gupta D, Lip GYH
Heart 2020 Oct;106(19):1463-1468. Epub 2020 Jul 16 doi: 10.1136/heartjnl-2020-316977. PMID: 32675218
Thachil J, Warkentin TE
Br J Haematol 2017 Apr;177(1):27-38. Epub 2016 Dec 16 doi: 10.1111/bjh.14482. PMID: 27982413
Kremer Hovinga JA, Studt JD, Lämmle B
Pathophysiol Haemost Thromb 2003 Sep-2004 Dec;33(5-6):417-21. doi: 10.1159/000083839. PMID: 15692254

Clinical prediction guides

Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Tiede A, Zieger B, Lisman T
Haemophilia 2021 Feb;27 Suppl 3:5-13. Epub 2020 Jun 1 doi: 10.1111/hae.14033. PMID: 32476241
Warkentin TE, Kaatz S
Thromb Res 2020 Dec;196:38-51. Epub 2020 Aug 10 doi: 10.1016/j.thromres.2020.08.017. PMID: 32841919Free PMC Article
Silva DSD, Teixeira LAC, Beghini DG, Ferreira ATDS, Pinho MBM, Rosa PS, Ribeiro MR, Freire MDC, Hacker MA, Nery JADC, Pessolani MCV, Tovar AMF, Sarno EN, Perales J, Bozza FA, Esquenazi D, Monteiro RQ, Lara FA
PLoS Negl Trop Dis 2018 Mar;12(3):e0006214. Epub 2018 Mar 22 doi: 10.1371/journal.pntd.0006214. PMID: 29565968Free PMC Article
Davies J, Kadir RA
Rev Endocr Metab Disord 2012 Dec;13(4):289-99. doi: 10.1007/s11154-012-9226-4. PMID: 23180227

Recent systematic reviews

Kalot MA, Husainat N, El Alayli A, Abughanimeh O, Diab O, Tayiem S, Madoukh B, Dimassi AB, Qureini A, Ameer B, Eikenboom JCJ, Giraud N, McLintock C, McRae S, Montgomery RR, O'Donnell JS, Scappe N, Sidonio RF, Brignardello-Petersen R, Flood VH, Connell NT, James PD, Mustafa RA
Blood Adv 2022 Jan 11;6(1):62-71. doi: 10.1182/bloodadvances.2021005430. PMID: 34610118Free PMC Article
Sikora J, Karczmarska-Wódzka A, Bugieda J, Sobczak P
Int J Mol Sci 2021 Aug 10;22(16) doi: 10.3390/ijms22168605. PMID: 34445311Free PMC Article
Harmsen MJ, Wong CFC, Mijatovic V, Griffioen AW, Groenman F, Hehenkamp WJK, Huirne JAF
Hum Reprod Update 2019 Sep 11;25(5):647-671. doi: 10.1093/humupd/dmz024. PMID: 31504506Free PMC Article
Loures CMG, Duarte RCF, Silva MVF, Cicarini WB, de Souza LC, Caramelli P, Borges KBG, Carvalho MDG
Semin Thromb Hemost 2019 Jul;45(5):514-522. Epub 2019 May 16 doi: 10.1055/s-0039-1688444. PMID: 31096308
Mostmans Y, Cutolo M, Giddelo C, Decuman S, Melsens K, Declercq H, Vandecasteele E, De Keyser F, Distler O, Gutermuth J, Smith V
Autoimmun Rev 2017 Aug;16(8):774-786. Epub 2017 May 29 doi: 10.1016/j.autrev.2017.05.024. PMID: 28572048

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...