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Abnormality of pancreas physiology

MedGen UID:
868647
•Concept ID:
C4023048
•
Pathologic Function
HPO: HP:0012091

Definition

An anomaly of the function of the pancreas. [from HPO]

Professional guidelines

PubMed

Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
Li Y, Li G, Suo L, Zhang J
Life Sci 2021 Jan 1;264:118641. Epub 2020 Oct 24 doi: 10.1016/j.lfs.2020.118641. PMID: 33148420
Genetics of Pancreatic Neoplasms and Role of Screening.
Katabathina VS, Rikhtehgar OY, Dasyam AK, Manickam R, Prasad SR
Magn Reson Imaging Clin N Am 2018 Aug;26(3):375-389. Epub 2018 Jun 8 doi: 10.1016/j.mric.2018.03.005. PMID: 30376976
How to use Rome IV criteria in the evaluation of esophageal disorders.
Schmulson M
Curr Opin Gastroenterol 2018 Jul;34(4):258-265. doi: 10.1097/MOG.0000000000000443. PMID: 29846258

Recent clinical studies

Etiology

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Hyperinsulinism in the Neonate.
Lord K, De León DD
Clin Perinatol 2018 Mar;45(1):61-74. Epub 2017 Dec 6 doi: 10.1016/j.clp.2017.10.007. PMID: 29406007
Chronic Pancreatitis.
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R
Diabetologia 2011 Oct;54(10):2506-14. Epub 2011 Jun 9 doi: 10.1007/s00125-011-2204-7. PMID: 21656330Free PMC Article
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860

Diagnosis

Pancreatic Malnutrition in Children.
Normatov I, Sentongo T
Pediatr Ann 2019 Nov 1;48(11):e441-e447. doi: 10.3928/19382359-20191018-01. PMID: 31710363
Hyperinsulinism in the Neonate.
Lord K, De León DD
Clin Perinatol 2018 Mar;45(1):61-74. Epub 2017 Dec 6 doi: 10.1016/j.clp.2017.10.007. PMID: 29406007
Chronic Pancreatitis.
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R
Diabetologia 2011 Oct;54(10):2506-14. Epub 2011 Jun 9 doi: 10.1007/s00125-011-2204-7. PMID: 21656330Free PMC Article
Amylase.
Garrison R
Emerg Med Clin North Am 1986 May;4(2):315-27. PMID: 2422011

Therapy

Structure and function of the exocrine pancreas in patients with type 1 diabetes.
Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E
Rev Endocr Metab Disord 2019 Jun;20(2):129-149. doi: 10.1007/s11154-019-09501-3. PMID: 31077020
Hyperinsulinism in the Neonate.
Lord K, De León DD
Clin Perinatol 2018 Mar;45(1):61-74. Epub 2017 Dec 6 doi: 10.1016/j.clp.2017.10.007. PMID: 29406007
Type 2 diabetes mellitus.
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R
Nat Rev Dis Primers 2015 Jul 23;1:15019. doi: 10.1038/nrdp.2015.19. PMID: 27189025
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R
Diabetologia 2011 Oct;54(10):2506-14. Epub 2011 Jun 9 doi: 10.1007/s00125-011-2204-7. PMID: 21656330Free PMC Article
Acute pancreatitis.
Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF
Ann Intern Med 1985 Jul;103(1):86-100. doi: 10.7326/0003-4819-103-1-86. PMID: 3890660

Prognosis

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860

Clinical prediction guides

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395Free PMC Article
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860
Acute pancreatitis.
Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF
Ann Intern Med 1985 Jul;103(1):86-100. doi: 10.7326/0003-4819-103-1-86. PMID: 3890660

Recent systematic reviews

Natural history of Wolcott-Rallison syndrome: A systematic review and follow-up study.
Aldrian D, Bochdansky C, Kavallar AM, Mayerhofer C, Deeb A, Habeb A, Romera Rabasa A, Khadilkar A, Uçar A, Knoppke B, Zafeiriou D, Lang-Muritano M, Miqdady M, Judmaier S, McLin V, Furdela V, Müller T, Vogel GF
Liver Int 2024 Mar;44(3):811-822. Epub 2024 Jan 17 doi: 10.1111/liv.15834. PMID: 38230874
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Early worsening of diabetic retinopathy after rapid improvement of blood glucose control in patients with diabetes.
Feldman-Billard S, Larger É, Massin P; Standards for screeningand surveillance of ocular complications in people with diabetes SFD study group
Diabetes Metab 2018 Feb;44(1):4-14. Epub 2017 Nov 11 doi: 10.1016/j.diabet.2017.10.014. PMID: 29217386
A systematic review on endoscopic detection rate, endotherapy, and surgery for pancreas divisum.
Liao Z, Gao R, Wang W, Ye Z, Lai XW, Wang XT, Hu LH, Li ZS
Endoscopy 2009 May;41(5):439-44. Epub 2009 Mar 31 doi: 10.1055/s-0029-1214505. PMID: 19337962
Acute idiopathic pancreatitis: does it really exist or is it a myth?
van Brummelen SE, Venneman NG, van Erpecum KJ, VanBerge-Henegouwen GP
Scand J Gastroenterol Suppl 2003;(239):117-22. doi: 10.1080/008559203100027. PMID: 14743894

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