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Abnormal pancreas morphology

MedGen UID:
868648
•Concept ID:
C4023049
•
Anatomical Abnormality
Synonyms: Abnormality of pancreas morphology; Abnormally shaped pancreas
 
HPO: HP:0012090

Professional guidelines

PubMed

Prenatal diagnosis of abdominal lymphatic malformations.
Liu YP, Huang YL, Tsai PS, Lin DC, Chen CP
Taiwan J Obstet Gynecol 2021 Jan;60(1):13-19. doi: 10.1016/j.tjog.2020.11.003. PMID: 33494985
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Diagnosis and treatment of pancreas divisum: A literature review.
Ferri V, Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R
Hepatobiliary Pancreat Dis Int 2019 Aug;18(4):332-336. Epub 2019 May 20 doi: 10.1016/j.hbpd.2019.05.004. PMID: 31155429

Recent clinical studies

Etiology

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Primate-specific ZNF808 is essential for pancreatic development in humans.
De Franco E, Owens NDL, Montaser H, Wakeling MN, Saarimäki-Vire J, Triantou A, Ibrahim H, Balboa D, Caswell RC, Jennings RE, Kvist JA, Johnson MB, Muralidharan S, Ellard S, Wright CF, Maddirevula S, Alkuraya FS; Pancreatic Agenesis Gene Discovery Consortium, Hanley NA, Flanagan SE, Otonkoski T, Hattersley AT, Imbeault M
Nat Genet 2023 Dec;55(12):2075-2081. Epub 2023 Nov 16 doi: 10.1038/s41588-023-01565-x. PMID: 37973953Free PMC Article
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Chronic Pancreatitis.
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364
Paediatric pancreatitis.
Pohl JF, Uc A
Curr Opin Gastroenterol 2015 Sep;31(5):380-6. doi: 10.1097/MOG.0000000000000197. PMID: 26181572Free PMC Article

Diagnosis

Annular pancreas.
Yakoubi C, Atri S, Maghrebi H, Kacem MJ
Br J Surg 2022 Sep 9;109(10):1012. doi: 10.1093/bjs/znac167. PMID: 36084336
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Diagnosis and treatment of pancreas divisum: A literature review.
Ferri V, Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R
Hepatobiliary Pancreat Dis Int 2019 Aug;18(4):332-336. Epub 2019 May 20 doi: 10.1016/j.hbpd.2019.05.004. PMID: 31155429
Paediatric pancreatitis.
Pohl JF, Uc A
Curr Opin Gastroenterol 2015 Sep;31(5):380-6. doi: 10.1097/MOG.0000000000000197. PMID: 26181572Free PMC Article
Pancreatic arteriovenous malformation.
Chou SC, Shyr YM, Wang SE
J Gastrointest Surg 2013 Jul;17(7):1240-6. Epub 2013 May 2 doi: 10.1007/s11605-013-2217-2. PMID: 23636883

Therapy

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu BJ, Marín-Cañas S, Salpea P, Sawatani T, Musuaya A, Arroyo MN, Moreno-Castro C, Benabdallah K, Demarez C, Toivonen S, Cosentino C, Pachera N, Lytrivi M, Cai Y, Carnel L, Brown C, Urano F, Marchetti P, Gilon P, Eizirik DL, Cnop M, Igoillo-Esteve M
Diabetologia 2023 Jul;66(7):1306-1321. Epub 2023 Mar 30 doi: 10.1007/s00125-023-05905-8. PMID: 36995380Free PMC Article
Hyperinsulinism in the Neonate.
Lord K, De León DD
Clin Perinatol 2018 Mar;45(1):61-74. Epub 2017 Dec 6 doi: 10.1016/j.clp.2017.10.007. PMID: 29406007
The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema.
Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR 3rd, Aguilar RB
Diabetes Care 2016 Feb;39(2):179-86. doi: 10.2337/dc15-1585. PMID: 26798148Free PMC Article
Paediatric pancreatitis.
Pohl JF, Uc A
Curr Opin Gastroenterol 2015 Sep;31(5):380-6. doi: 10.1097/MOG.0000000000000197. PMID: 26181572Free PMC Article
Acute pancreatitis.
Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF
Ann Intern Med 1985 Jul;103(1):86-100. doi: 10.7326/0003-4819-103-1-86. PMID: 3890660

Prognosis

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Paediatric pancreatitis.
Pohl JF, Uc A
Curr Opin Gastroenterol 2015 Sep;31(5):380-6. doi: 10.1097/MOG.0000000000000197. PMID: 26181572Free PMC Article
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article

Clinical prediction guides

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans.
Takahashi M, Hori M, Ishigamori R, Mutoh M, Imai T, Nakagama H
Cancer Sci 2018 Oct;109(10):3013-3023. Epub 2018 Sep 5 doi: 10.1111/cas.13766. PMID: 30099827Free PMC Article
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Acute pancreatitis.
Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF
Ann Intern Med 1985 Jul;103(1):86-100. doi: 10.7326/0003-4819-103-1-86. PMID: 3890660

Recent systematic reviews

Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.
Hansen CC, Søreide K
Medicine (Baltimore) 2018 Aug;97(35):e12154. doi: 10.1097/MD.0000000000012154. PMID: 30170459Free PMC Article
A systematic review and quantitative analysis of different therapies for pancreas divisum.
Hafezi M, Mayschak B, Probst P, Büchler MW, Hackert T, Mehrabi A
Am J Surg 2017 Sep;214(3):525-537. Epub 2017 Jan 3 doi: 10.1016/j.amjsurg.2016.12.025. PMID: 28110914
Agenesis of the dorsal pancreas: systematic review of a clinical challenge.
Cienfuegos JA, Rotellar F, Salguero J, Benito A, Solórzano JL, Sangro B
Rev Esp Enferm Dig 2016 Aug;108(8):479-84. doi: 10.17235/reed.2016.4474/2016. PMID: 27468966
Endotherapy in symptomatic pancreas divisum: a systematic review.
Kanth R, Samji NS, Inaganti A, Komanapalli SD, Rivera R, Antillon MR, Roy PK
Pancreatology 2014 Jul-Aug;14(4):244-50. Epub 2014 Jun 11 doi: 10.1016/j.pan.2014.05.796. PMID: 25062871

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