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Increased urinary cortisol level

MedGen UID:
868666
Concept ID:
C4023068
Finding
Synonym: High urine cortisol level
 
HPO: HP:0012030

Definition

Abnormally increased concentration of cortisol in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary cortisol level

Conditions with this feature

Pigmented nodular adrenocortical disease, primary, 1
MedGen UID:
400627
Concept ID:
C1864846
Disease or Syndrome
Primary pigmented nodular adrenocortical disease (PPNAD) is a form of ACTH-independent adrenal hyperplasia resulting in Cushing syndrome. It is usually seen as a manifestation of the Carney complex (CNC1; 160980), a multiple neoplasia syndrome. However, PPNAD can also occur in isolation (Groussin et al., 2002). Genetic Heterogeneity of Primary Pigmented Nodular Adrenocortical Disease See also PPNAD2 (610475), caused by mutation in the PDE11A gene (604961) on chromosome 2q31; PPNAD3 (614190), caused by mutation in the PDE8B gene (603390) on chromosome 5q13; and PPNAD4 (615830), caused by a duplication on chromosome 19p13 that includes the PRKACA gene (601639).
ACTH-independent macronodular adrenal hyperplasia 2
MedGen UID:
863240
Concept ID:
C4014803
Disease or Syndrome
ACTH-independent macronodular adrenal hyperplasia-2 is an autosomal dominant tumor susceptibility with syndromic incomplete penetrance, as a second hit to the ARMC5 gene is required to develop macronodular hyperplasia (Assie et al., 2013).

Professional guidelines

PubMed

Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Vassiliadi DA, Tsagarakis S
Endocr Relat Cancer 2019 Oct 1;26(10):R567-R581. doi: 10.1530/ERC-19-0240. PMID: 32053747
Assadi F
Iran J Kidney Dis 2008 Jul;2(3):115-22. PMID: 19377223

Recent clinical studies

Etiology

Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Casas I, Nakaki A, Pascal R, Castro-Barquero S, Youssef L, Genero M, Benitez L, Larroya M, Boutet ML, Casu G, Gomez-Gomez A, Pozo OJ, Morilla I, Martínez-Àran A, Vieta E, Gómez-Roig MD, Casas R, Estruch R, Gratacos E, Crispi F, Crovetto F
Nutrients 2023 May 18;15(10) doi: 10.3390/nu15102362. PMID: 37242244Free PMC Article
Guerrieri GM, Ben Dor R, Li X, Wei SM, Martinez PE, Neiman LK, Rubinow DR, Schmidt PJ
J Clin Endocrinol Metab 2021 Sep 27;106(10):3007-3018. doi: 10.1210/clinem/dgab407. PMID: 34097071Free PMC Article
Cheng L, Lucchesi S, Mundry R, Samuni L, Deschner T, Surbeck M
Horm Behav 2021 Feb;128:104914. Epub 2020 Dec 30 doi: 10.1016/j.yhbeh.2020.104914. PMID: 33373622
Araujo-Castro M, Sampedro Núñez MA, Marazuela M
Endocrine 2019 Apr;64(1):1-13. Epub 2019 Mar 7 doi: 10.1007/s12020-019-01888-y. PMID: 30847651

Diagnosis

Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Araujo-Castro M, Sampedro Núñez MA, Marazuela M
Endocrine 2019 Apr;64(1):1-13. Epub 2019 Mar 7 doi: 10.1007/s12020-019-01888-y. PMID: 30847651
Cyrańska-Chyrek E, Grzymisławska M, Ruchała M
Endokrynol Pol 2017;68(3):360-377. doi: 10.5603/EP.2017.0028. PMID: 28660993
Assadi F
Iran J Kidney Dis 2008 Jul;2(3):115-22. PMID: 19377223

Therapy

Majeed M, Nagabhushanam K, Mundkur L
Medicine (Baltimore) 2023 Oct 13;102(41):e35521. doi: 10.1097/MD.0000000000035521. PMID: 37832082Free PMC Article
Casas I, Nakaki A, Pascal R, Castro-Barquero S, Youssef L, Genero M, Benitez L, Larroya M, Boutet ML, Casu G, Gomez-Gomez A, Pozo OJ, Morilla I, Martínez-Àran A, Vieta E, Gómez-Roig MD, Casas R, Estruch R, Gratacos E, Crispi F, Crovetto F
Nutrients 2023 May 18;15(10) doi: 10.3390/nu15102362. PMID: 37242244Free PMC Article
Perosevic M, Tritos NA
Drug Des Devel Ther 2023;17:1303-1312. Epub 2023 Apr 27 doi: 10.2147/DDDT.S315359. PMID: 37143705Free PMC Article
Vassiliadi DA, Partsalaki E, Tsagarakis S
Curr Opin Endocrinol Diabetes Obes 2020 Jun;27(3):125-131. doi: 10.1097/MED.0000000000000536. PMID: 32209820
Assadi F
Iran J Kidney Dis 2008 Jul;2(3):115-22. PMID: 19377223

Prognosis

Meneguzzo P, Mancini C, Terlizzi S, Sales C, Francesconi MF, Todisco P
Eur Eat Disord Rev 2022 Jul;30(4):364-372. Epub 2022 Mar 10 doi: 10.1002/erv.2896. PMID: 35274398Free PMC Article
Gartland N, Rosmalen JGM, O'Connor DB
Psychoneuroendocrinology 2022 Apr;138:105664. Epub 2022 Jan 10 doi: 10.1016/j.psyneuen.2022.105664. PMID: 35063686
Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H
Clin Endocrinol (Oxf) 2021 Apr;94(4):544-550. Epub 2020 Dec 17 doi: 10.1111/cen.14385. PMID: 33296503
Carvajal CA, Tapia-Castillo A, Vecchiola A, Baudrand R, Fardella CE
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz315. PMID: 31909799
Bertagna X, Guignat L, Groussin L, Bertherat J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):607-23. doi: 10.1016/j.beem.2009.06.001. PMID: 19945026

Clinical prediction guides

Majeed M, Nagabhushanam K, Mundkur L
Medicine (Baltimore) 2023 Oct 13;102(41):e35521. doi: 10.1097/MD.0000000000035521. PMID: 37832082Free PMC Article
Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427
Casas I, Nakaki A, Pascal R, Castro-Barquero S, Youssef L, Genero M, Benitez L, Larroya M, Boutet ML, Casu G, Gomez-Gomez A, Pozo OJ, Morilla I, Martínez-Àran A, Vieta E, Gómez-Roig MD, Casas R, Estruch R, Gratacos E, Crispi F, Crovetto F
Nutrients 2023 May 18;15(10) doi: 10.3390/nu15102362. PMID: 37242244Free PMC Article
Li Q
Environ Health Prev Med 2022;27:43. doi: 10.1265/ehpm.22-00160. PMID: 36328581Free PMC Article
Chu L, Shen K, Liu P, Ye K, Wang Y, Li C, Kang X, Song Y
Med Sci Monit Basic Res 2017 Feb 9;23:25-30. doi: 10.12659/msmbr.902707. PMID: 28179618Free PMC Article

Recent systematic reviews

Beiner E, Lucas V, Reichert J, Buhai DV, Jesinghaus M, Vock S, Drusko A, Baumeister D, Eich W, Friederich HC, Tesarz J
Pain 2023 Jul 1;164(7):1416-1427. Epub 2023 Jan 5 doi: 10.1097/j.pain.0000000000002857. PMID: 36728497
Sridharan K, Sahoo J, Palui R, Patil M, Kamalanathan S, Ramesh AS, Kubera NS
Pituitary 2021 Oct;24(5):670-680. Epub 2021 Mar 29 doi: 10.1007/s11102-021-01142-7. PMID: 33779937
Piancino MG, Tortarolo A, Polimeni A, Cannavale R, Tonni I, Deregibus A
Arch Oral Biol 2019 Nov;107:104516. Epub 2019 Aug 5 doi: 10.1016/j.archoralbio.2019.104516. PMID: 31408810

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