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Cardiovascular calcification

MedGen UID:
868723
•Concept ID:
C4023128
•
Pathologic Function
HPO: HP:0011915

Definition

Abnormal calcification in the cardiovascular system. [from HPO]

Professional guidelines

PubMed

Current and potential treatment options for hyperphosphatemia.
Carfagna F, Del Vecchio L, Pontoriero G, Locatelli F
Expert Opin Drug Saf 2018 Jun;17(6):597-607. Epub 2018 May 21 doi: 10.1080/14740338.2018.1476487. PMID: 29783873
Treatment of cardiovascular calcification in uremia.
Mazzaferro S, Pasquali M, Cozzolino M
Curr Vasc Pharmacol 2011 Nov;9(6):741-9. doi: 10.2174/157016111797484161. PMID: 21824104
Cardiovascular disease determinants in chronic renal failure: clinical approach and treatment.
Locatelli F, Bommer J, London GM, Martín-Malo A, Wanner C, Yaqoob M, Zoccali C
Nephrol Dial Transplant 2001 Mar;16(3):459-68. doi: 10.1093/ndt/16.3.459. PMID: 11239016

Recent clinical studies

Etiology

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.
Skenteris NT, Seime T, Witasp A, Karlöf E, Wasilewski GB, Heuschkel MA, Jaminon AMG, Oduor L, Dzhanaev R, Kronqvist M, Lengquist M, Peeters FECM, Söderberg M, Hultgren R, Roy J, Maegdefessel L, Arnardottir H, Bengtsson E, Goncalves I, Quertermous T, Goettsch C, Stenvinkel P, Schurgers LJ, Matic L
Clin Transl Med 2022 Feb;12(2):e682. doi: 10.1002/ctm2.682. PMID: 35184400Free PMC Article
Biomolecules Orchestrating Cardiovascular Calcification.
Tintut Y, Honda HM, Demer LL
Biomolecules 2021 Oct 7;11(10) doi: 10.3390/biom11101482. PMID: 34680115Free PMC Article
Lipids and cardiovascular calcification: contributions to plaque vulnerability.
Hsu JJ, Tintut Y, Demer LL
Curr Opin Lipidol 2021 Oct 1;32(5):308-314. doi: 10.1097/MOL.0000000000000777. PMID: 34320564Free PMC Article
Hereditary Disorders of Cardiovascular Calcification.
Rutsch F, Buers I, Nitschke Y
Arterioscler Thromb Vasc Biol 2021 Jan;41(1):35-47. Epub 2020 Nov 12 doi: 10.1161/ATVBAHA.120.315577. PMID: 33176451
Vascular calcification.
Massy ZA, Drüeke TB
Curr Opin Nephrol Hypertens 2013 Jul;22(4):405-12. doi: 10.1097/MNH.0b013e328362155b. PMID: 23722182

Diagnosis

Influence of rivaroxaban compared to vitamin K antagonist treatment upon development of cardiovascular calcification in patients with atrial fibrillation and/or pulmonary embolism.
Stöhr R, Dirrichs T, Kneizeh K, Reinartz S, Frank D, Brachmann J, Schroeder J, Schurgers L, Göttsch C, Keszei A, Floege J, Marx N, Brandenburg V, Schuh A
Clin Cardiol 2022 Apr;45(4):352-358. Epub 2022 Mar 25 doi: 10.1002/clc.23819. PMID: 35332571Free PMC Article
Hereditary Disorders of Cardiovascular Calcification.
Rutsch F, Buers I, Nitschke Y
Arterioscler Thromb Vasc Biol 2021 Jan;41(1):35-47. Epub 2020 Nov 12 doi: 10.1161/ATVBAHA.120.315577. PMID: 33176451
Innate and adaptive immunity in cardiovascular calcification.
Passos LSA, Lupieri A, Becker-Greene D, Aikawa E
Atherosclerosis 2020 Aug;306:59-67. Epub 2020 Feb 28 doi: 10.1016/j.atherosclerosis.2020.02.016. PMID: 32222287Free PMC Article
Imaging Cardiovascular Calcification.
Wang Y, Osborne MT, Tung B, Li M, Li Y
J Am Heart Assoc 2018 Jun 28;7(13) doi: 10.1161/JAHA.118.008564. PMID: 29954746Free PMC Article
Vascular calcification.
Massy ZA, Drüeke TB
Curr Opin Nephrol Hypertens 2013 Jul;22(4):405-12. doi: 10.1097/MNH.0b013e328362155b. PMID: 23722182

Therapy

Influence of rivaroxaban compared to vitamin K antagonist treatment upon development of cardiovascular calcification in patients with atrial fibrillation and/or pulmonary embolism.
Stöhr R, Dirrichs T, Kneizeh K, Reinartz S, Frank D, Brachmann J, Schroeder J, Schurgers L, Göttsch C, Keszei A, Floege J, Marx N, Brandenburg V, Schuh A
Clin Cardiol 2022 Apr;45(4):352-358. Epub 2022 Mar 25 doi: 10.1002/clc.23819. PMID: 35332571Free PMC Article
Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.
Kaesler N, Schreibing F, Speer T, Puente-Secades S, Rapp N, Drechsler C, Kabgani N, Kuppe C, Boor P, Jankowski V, Schurgers L, Kramann R, Floege J
Kidney Int 2022 Feb;101(2):338-348. Epub 2021 Nov 11 doi: 10.1016/j.kint.2021.10.029. PMID: 34774554
Cardiovascular calcifications in kidney transplant recipients.
Podestà MA, Cucchiari D, Ciceri P, Messa P, Torregrosa JV, Cozzolino M
Nephrol Dial Transplant 2022 Oct 19;37(11):2063-2071. doi: 10.1093/ndt/gfab053. PMID: 33620476
Vitamin K and cardiovascular complications in chronic kidney disease patients.
Kaesler N, Schurgers LJ, Floege J
Kidney Int 2021 Nov;100(5):1023-1036. Epub 2021 Jul 24 doi: 10.1016/j.kint.2021.06.037. PMID: 34310988
Network determinants of cardiovascular calcification and repositioned drug treatments.
Song E, Wang RS, Leopold JA, Loscalzo J
FASEB J 2020 Aug;34(8):11087-11100. Epub 2020 Jul 8 doi: 10.1096/fj.202001062R. PMID: 32638415Free PMC Article

Prognosis

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.
Bessueille L, Kawtharany L, Quillard T, Goettsch C, Briolay A, Taraconat N, Balayssac S, Gilard V, Mebarek S, Peyruchaud O, Duboeuf F, Bouillot C, Pinkerton A, Mechtouff L, Buchet R, Hamade E, Zibara K, Fonta C, Canet-Soulas E, Millan JL, Magne D
Transl Res 2023 Jan;251:2-13. Epub 2022 Jun 17 doi: 10.1016/j.trsl.2022.06.010. PMID: 35724933
Lipids and cardiovascular calcification: contributions to plaque vulnerability.
Hsu JJ, Tintut Y, Demer LL
Curr Opin Lipidol 2021 Oct 1;32(5):308-314. doi: 10.1097/MOL.0000000000000777. PMID: 34320564Free PMC Article
Network determinants of cardiovascular calcification and repositioned drug treatments.
Song E, Wang RS, Leopold JA, Loscalzo J
FASEB J 2020 Aug;34(8):11087-11100. Epub 2020 Jul 8 doi: 10.1096/fj.202001062R. PMID: 32638415Free PMC Article
Imaging Cardiovascular Calcification.
Wang Y, Osborne MT, Tung B, Li M, Li Y
J Am Heart Assoc 2018 Jun 28;7(13) doi: 10.1161/JAHA.118.008564. PMID: 29954746Free PMC Article
Vascular calcification.
Massy ZA, Drüeke TB
Curr Opin Nephrol Hypertens 2013 Jul;22(4):405-12. doi: 10.1097/MNH.0b013e328362155b. PMID: 23722182

Clinical prediction guides

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.
Bessueille L, Kawtharany L, Quillard T, Goettsch C, Briolay A, Taraconat N, Balayssac S, Gilard V, Mebarek S, Peyruchaud O, Duboeuf F, Bouillot C, Pinkerton A, Mechtouff L, Buchet R, Hamade E, Zibara K, Fonta C, Canet-Soulas E, Millan JL, Magne D
Transl Res 2023 Jan;251:2-13. Epub 2022 Jun 17 doi: 10.1016/j.trsl.2022.06.010. PMID: 35724933
Vitamin K and cardiovascular complications in chronic kidney disease patients.
Kaesler N, Schurgers LJ, Floege J
Kidney Int 2021 Nov;100(5):1023-1036. Epub 2021 Jul 24 doi: 10.1016/j.kint.2021.06.037. PMID: 34310988
Network determinants of cardiovascular calcification and repositioned drug treatments.
Song E, Wang RS, Leopold JA, Loscalzo J
FASEB J 2020 Aug;34(8):11087-11100. Epub 2020 Jul 8 doi: 10.1096/fj.202001062R. PMID: 32638415Free PMC Article
Imaging Cardiovascular Calcification.
Wang Y, Osborne MT, Tung B, Li M, Li Y
J Am Heart Assoc 2018 Jun 28;7(13) doi: 10.1161/JAHA.118.008564. PMID: 29954746Free PMC Article
Vascular calcification.
Massy ZA, Drüeke TB
Curr Opin Nephrol Hypertens 2013 Jul;22(4):405-12. doi: 10.1097/MNH.0b013e328362155b. PMID: 23722182

Recent systematic reviews

Effects of lanthanum carbonate and calcium carbonate on cardiovascular calcification in hemodialysis patients: A systematic review and meta-analysis.
Yang J, Zhang X, Wang L
Clin Nephrol 2022 Jan;97(1):18-26. doi: 10.5414/CN110522. PMID: 34448696
Uremic Toxins Affecting Cardiovascular Calcification: A Systematic Review.
Holmar J, de la Puente-Secades S, Floege J, Noels H, Jankowski J, Orth-Alampour S
Cells 2020 Nov 6;9(11) doi: 10.3390/cells9112428. PMID: 33172085Free PMC Article
Effects of serum phosphorus on vascular calcification in a healthy, adult population: A systematic review.
Sheridan K, Logomarsino JV
J Vasc Nurs 2017 Sep;35(3):157-169. doi: 10.1016/j.jvn.2017.01.003. PMID: 28838591
Comparison between paricalcitol and active non-selective vitamin D receptor activator for secondary hyperparathyroidism in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.
Cai P, Tang X, Qin W, Ji L, Li Z
Int Urol Nephrol 2016 Apr;48(4):571-84. Epub 2016 Jan 9 doi: 10.1007/s11255-015-1195-6. PMID: 26748501
Cystic fibrosis-related bone disease.
Paccou J, Fardellone P, Cortet B
Curr Opin Pulm Med 2013 Nov;19(6):681-6. doi: 10.1097/MCP.0b013e3283659e35. PMID: 24060979

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