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Reduced hemoglobin A

MedGen UID:
868733
Concept ID:
C4023138
Finding
Synonyms: Reduced haemoglobin A; Reduced HbA
 
HPO: HP:0011905

Definition

Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced hemoglobin A

Professional guidelines

PubMed

Affan A, Zurada JM, Inane T
Annu Int Conf IEEE Eng Med Biol Soc 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10340171. PMID: 38083458
Cacic DL, Hervig T, Seghatchian J
Transfus Apher Sci 2013 Apr;48(2):277-81. Epub 2013 Mar 7 doi: 10.1016/j.transci.2013.01.018. PMID: 23465378
Younk LM, Davis SN
Expert Opin Drug Metab Toxicol 2012 Apr;8(4):515-25. doi: 10.1517/17425255.2012.672973. PMID: 22432790

Recent clinical studies

Etiology

Jansson AK, Chan LX, Lubans DR, Duncan MJ, Plotnikoff RC
BMJ Open Diabetes Res Care 2022 Mar;10(2) doi: 10.1136/bmjdrc-2021-002595. PMID: 35273011Free PMC Article
Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M
Adv Exp Med Biol 2020;1228:91-105. doi: 10.1007/978-981-15-1792-1_6. PMID: 32342452
Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC
Am J Kidney Dis 2019 Sep;74(3):328-337. Epub 2019 May 14 doi: 10.1053/j.ajkd.2019.03.417. PMID: 31101403Free PMC Article
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protégé Trial Investigators
Lancet 2011 Aug 6;378(9790):487-97. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60931-8. PMID: 21719095Free PMC Article

Diagnosis

Durrer C, McKelvey S, Singer J, Batterham AM, Johnson JD, Gudmundson K, Wortman J, Little JP
Nat Commun 2021 Sep 10;12(1):5367. doi: 10.1038/s41467-021-25667-4. PMID: 34508090Free PMC Article
Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M
Adv Exp Med Biol 2020;1228:91-105. doi: 10.1007/978-981-15-1792-1_6. PMID: 32342452
Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ
J Acad Nutr Diet 2015 Sep;115(9):1447-63. Epub 2015 Apr 29 doi: 10.1016/j.jand.2015.02.031. PMID: 25935570
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protégé Trial Investigators
Lancet 2011 Aug 6;378(9790):487-97. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60931-8. PMID: 21719095Free PMC Article
Yip MP, Chang AM, Chan J, MacKenzie AE
J Telemed Telecare 2003;9(1):46-50. doi: 10.1258/135763303321159693. PMID: 12641893

Therapy

Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Meier JJ
Front Endocrinol (Lausanne) 2021;12:645617. Epub 2021 Jun 25 doi: 10.3389/fendo.2021.645617. PMID: 34248838Free PMC Article
Eberle C, Löhnert M, Stichling S
JMIR Mhealth Uhealth 2021 Feb 15;9(2):e23477. doi: 10.2196/23477. PMID: 33587045Free PMC Article
Hals IK
Curr Diabetes Rev 2019;15(3):188-193. doi: 10.2174/1573399814666180716144429. PMID: 30009709
Leach MJ, Kumar S
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007170. doi: 10.1002/14651858.CD007170.pub2. PMID: 22972104Free PMC Article

Prognosis

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL
Br J Sports Med 2021 Aug;55(15):865-872. Epub 2021 Mar 1 doi: 10.1136/bjsports-2020-103106. PMID: 33648944Free PMC Article
Ji H, Chen R, Huang Y, Li W, Shi C, Zhou J
Diabetes Metab Res Rev 2019 Mar;35(3):e3112. Epub 2018 Dec 21 doi: 10.1002/dmrr.3112. PMID: 30520255Free PMC Article
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, Chu Y, Iyoha E, Segal JB, Bolen S
Ann Intern Med 2016 Jun 7;164(11):740-51. Epub 2016 Apr 19 doi: 10.7326/M15-2650. PMID: 27088241
Nathan DM; DCCT/EDIC Research Group
Diabetes Care 2014;37(1):9-16. doi: 10.2337/dc13-2112. PMID: 24356592Free PMC Article
Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR
BMJ 2000 Aug 12;321(7258):405-12. doi: 10.1136/bmj.321.7258.405. PMID: 10938048Free PMC Article

Clinical prediction guides

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL
Br J Sports Med 2021 Aug;55(15):865-872. Epub 2021 Mar 1 doi: 10.1136/bjsports-2020-103106. PMID: 33648944Free PMC Article
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article
Harrison SA, Ratziu V, Boursier J, Francque S, Bedossa P, Majd Z, Cordonnier G, Sudrik FB, Darteil R, Liebe R, Magnanensi J, Hajji Y, Brozek J, Roudot A, Staels B, Hum DW, Megnien SJ, Hosmane S, Dam N, Chaumat P, Hanf R, Anstee QM, Sanyal AJ
Lancet Gastroenterol Hepatol 2020 Nov;5(11):970-985. Epub 2020 Aug 5 doi: 10.1016/S2468-1253(20)30252-1. PMID: 32763196
Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC
Am J Kidney Dis 2019 Sep;74(3):328-337. Epub 2019 May 14 doi: 10.1053/j.ajkd.2019.03.417. PMID: 31101403Free PMC Article
Nitin S
Singapore Med J 2010 Aug;51(8):616-22. PMID: 20848057

Recent systematic reviews

Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Karagiannis T, Avgerinos I, Liakos A, Del Prato S, Matthews DR, Tsapas A, Bekiari E
Diabetologia 2022 Aug;65(8):1251-1261. Epub 2022 May 17 doi: 10.1007/s00125-022-05715-4. PMID: 35579691Free PMC Article
Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E
Ann Intern Med 2020 Aug 18;173(4):278-286. Epub 2020 Jun 30 doi: 10.7326/M20-0864. PMID: 32598218
Baeza M, Morales A, Cisterna C, Cavalla F, Jara G, Isamitt Y, Pino P, Gamonal J
J Appl Oral Sci 2020;28:e20190248. Epub 2020 Jan 10 doi: 10.1590/1678-7757-2019-0248. PMID: 31939522Free PMC Article
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, Chu Y, Iyoha E, Segal JB, Bolen S
Ann Intern Med 2016 Jun 7;164(11):740-51. Epub 2016 Apr 19 doi: 10.7326/M15-2650. PMID: 27088241

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