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Reduced hemoglobin A

MedGen UID:
868733
•Concept ID:
C4023138
•
Finding
Synonyms: Reduced haemoglobin A; Reduced HbA
 
HPO: HP:0011905

Definition

Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced hemoglobin A

Professional guidelines

PubMed

Patient-Specific Modeling and Model Predictive Control Approach to Personalized Optimal Anemia Management.
Affan A, Zurada JM, Inane T
Annu Int Conf IEEE Eng Med Biol Soc 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10340171. PMID: 38083458
Anemia treatment of lymphoproliferative malignancies with erypoiesis: an overview of state of the art.
Cacic DL, Hervig T, Seghatchian J
Transfus Apher Sci 2013 Apr;48(2):277-81. Epub 2013 Mar 7 doi: 10.1016/j.transci.2013.01.018. PMID: 23465378
Evaluation of colesevelam hydrochloride for the treatment of type 2 diabetes.
Younk LM, Davis SN
Expert Opin Drug Metab Toxicol 2012 Apr;8(4):515-25. doi: 10.1517/17425255.2012.672973. PMID: 22432790

Recent clinical studies

Etiology

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.
Yao H, Zhang A, Li D, Wu Y, Wang CZ, Wan JY, Yuan CS
BMJ 2024 Jan 29;384:e076410. doi: 10.1136/bmj-2023-076410. PMID: 38286487Free PMC Article
Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis.
Jansson AK, Chan LX, Lubans DR, Duncan MJ, Plotnikoff RC
BMJ Open Diabetes Res Care 2022 Mar;10(2) doi: 10.1136/bmjdrc-2021-002595. PMID: 35273011Free PMC Article
Exercise and Type 2 Diabetes.
Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M
Adv Exp Med Biol 2020;1228:91-105. doi: 10.1007/978-981-15-1792-1_6. PMID: 32342452
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial.
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protégé Trial Investigators
Lancet 2011 Aug 6;378(9790):487-97. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60931-8. PMID: 21719095Free PMC Article

Diagnosis

A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes.
Durrer C, McKelvey S, Singer J, Batterham AM, Johnson JD, Gudmundson K, Wortman J, Little JP
Nat Commun 2021 Sep 10;12(1):5367. doi: 10.1038/s41467-021-25667-4. PMID: 34508090Free PMC Article
Exercise and Type 2 Diabetes.
Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M
Adv Exp Med Biol 2020;1228:91-105. doi: 10.1007/978-981-15-1792-1_6. PMID: 32342452
Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials.
Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJ
J Acad Nutr Diet 2015 Sep;115(9):1447-63. Epub 2015 Apr 29 doi: 10.1016/j.jand.2015.02.031. PMID: 25935570
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial.
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protégé Trial Investigators
Lancet 2011 Aug 6;378(9790):487-97. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60931-8. PMID: 21719095Free PMC Article
Development of the Telemedicine Satisfaction Questionnaire to evaluate patient satisfaction with telemedicine: a preliminary study.
Yip MP, Chang AM, Chan J, MacKenzie AE
J Telemed Telecare 2003;9(1):46-50. doi: 10.1258/135763303321159693. PMID: 12641893

Therapy

Finerenone in diabetic kidney disease: A systematic review and critical appraisal.
Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation.
Meier JJ
Front Endocrinol (Lausanne) 2021;12:645617. Epub 2021 Jun 25 doi: 10.3389/fendo.2021.645617. PMID: 34248838Free PMC Article
Effectiveness of Disease-Specific mHealth Apps in Patients With Diabetes Mellitus: Scoping Review.
Eberle C, Löhnert M, Stichling S
JMIR Mhealth Uhealth 2021 Feb 15;9(2):e23477. doi: 10.2196/23477. PMID: 33587045Free PMC Article
Mobile App for Improved Self-Management of Type 2 Diabetes: Multicenter Pragmatic Randomized Controlled Trial.
Agarwal P, Mukerji G, Desveaux L, Ivers NM, Bhattacharyya O, Hensel JM, Shaw J, Bouck Z, Jamieson T, Onabajo N, Cooper M, Marani H, Jeffs L, Bhatia RS
JMIR Mhealth Uhealth 2019 Jan 10;7(1):e10321. doi: 10.2196/10321. PMID: 30632972Free PMC Article
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub4. PMID: 27731885Free PMC Article

Prognosis

How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation.
Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL
Br J Sports Med 2021 Aug;55(15):865-872. Epub 2021 Mar 1 doi: 10.1136/bjsports-2020-103106. PMID: 33648944Free PMC Article
Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes.
van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, Willems van Dijk K, Longo VD, Lamb HJ, Numans ME, Pijl H
BMC Endocr Disord 2020 Jun 24;20(1):94. doi: 10.1186/s12902-020-00576-7. PMID: 32580710Free PMC Article
Effect of simulation education and case management on glycemic control in type 2 diabetes.
Ji H, Chen R, Huang Y, Li W, Shi C, Zhou J
Diabetes Metab Res Rev 2019 Mar;35(3):e3112. Epub 2018 Dec 21 doi: 10.1002/dmrr.3112. PMID: 30520255Free PMC Article
Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis.
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, Chu Y, Iyoha E, Segal JB, Bolen S
Ann Intern Med 2016 Jun 7;164(11):740-51. Epub 2016 Apr 19 doi: 10.7326/M15-2650. PMID: 27088241
The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview.
Nathan DM; DCCT/EDIC Research Group
Diabetes Care 2014;37(1):9-16. doi: 10.2337/dc13-2112. PMID: 24356592Free PMC Article

Clinical prediction guides

A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes.
Durrer C, McKelvey S, Singer J, Batterham AM, Johnson JD, Gudmundson K, Wortman J, Little JP
Nat Commun 2021 Sep 10;12(1):5367. doi: 10.1038/s41467-021-25667-4. PMID: 34508090Free PMC Article
How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation.
Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL
Br J Sports Med 2021 Aug;55(15):865-872. Epub 2021 Mar 1 doi: 10.1136/bjsports-2020-103106. PMID: 33648944Free PMC Article
A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study.
Harrison SA, Ratziu V, Boursier J, Francque S, Bedossa P, Majd Z, Cordonnier G, Sudrik FB, Darteil R, Liebe R, Magnanensi J, Hajji Y, Brozek J, Roudot A, Staels B, Hum DW, Megnien SJ, Hosmane S, Dam N, Chaumat P, Hanf R, Anstee QM, Sanyal AJ
Lancet Gastroenterol Hepatol 2020 Nov;5(11):970-985. Epub 2020 Aug 5 doi: 10.1016/S2468-1253(20)30252-1. PMID: 32763196
Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD.
Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC
Am J Kidney Dis 2019 Sep;74(3):328-337. Epub 2019 May 14 doi: 10.1053/j.ajkd.2019.03.417. PMID: 31101403Free PMC Article
HbA1c and factors other than diabetes mellitus affecting it.
Nitin S
Singapore Med J 2010 Aug;51(8):616-22. PMID: 20848057

Recent systematic reviews

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.
Yao H, Zhang A, Li D, Wu Y, Wang CZ, Wan JY, Yuan CS
BMJ 2024 Jan 29;384:e076410. doi: 10.1136/bmj-2023-076410. PMID: 38286487Free PMC Article
Finerenone in diabetic kidney disease: A systematic review and critical appraisal.
Singh AK, Singh A, Singh R, Misra A
Diabetes Metab Syndr 2022 Oct;16(10):102638. Epub 2022 Oct 4 doi: 10.1016/j.dsx.2022.102638. PMID: 36223666
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis.
Karagiannis T, Avgerinos I, Liakos A, Del Prato S, Matthews DR, Tsapas A, Bekiari E
Diabetologia 2022 Aug;65(8):1251-1261. Epub 2022 May 17 doi: 10.1007/s00125-022-05715-4. PMID: 35579691Free PMC Article
Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.
Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E
Ann Intern Med 2020 Aug 18;173(4):278-286. Epub 2020 Jun 30 doi: 10.7326/M20-0864. PMID: 32598218
Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis.
Baeza M, Morales A, Cisterna C, Cavalla F, Jara G, Isamitt Y, Pino P, Gamonal J
J Appl Oral Sci 2020;28:e20190248. Epub 2020 Jan 10 doi: 10.1590/1678-7757-2019-0248. PMID: 31939522Free PMC Article

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