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Partial IgA deficiency

MedGen UID:
868762
Concept ID:
C4023167
Finding
HPO: HP:0011837

Definition

Detectable but decreased IgA levels that are more than 2 standard deviations below normal age-adjusted means. [from HPO]

Term Hierarchy

Recent clinical studies

Etiology

Živković J, Lipej M, Banić I, Bulat Lokas S, Nogalo B, Lulić Jurjević R, Turkalj M
Scand J Immunol 2019 Dec;90(6):e12828. Epub 2019 Oct 24 doi: 10.1111/sji.12828. PMID: 31520490
Moschese V, Chini L, Graziani S, Sgrulletti M, Gallo V, Di Matteo G, Ferrari S, Di Cesare S, Cirillo E, Pession A, Pignata C, Specchia F
Eur J Pediatr 2019 Jan;178(1):51-60. Epub 2018 Sep 29 doi: 10.1007/s00431-018-3248-1. PMID: 30269248
Cipe FE, Doğu F, Güloğlu D, Aytekin C, Polat M, Biyikli Z, Ikincioğullari A
J Investig Allergol Clin Immunol 2013;23(2):94-100. PMID: 23654075
Shakkottai A, Bupathi K, Patel AP, Chalom E, Chamarthi S, Lehman TJ, Peterson MG, Gaur S, Moorthy LN
Clin Pediatr (Phila) 2012 Jan;51(1):46-50. Epub 2011 Aug 25 doi: 10.1177/0009922811417287. PMID: 21868598
Mieli-Vergani G, Vergani D
World J Gastroenterol 2008 Jun 7;14(21):3360-7. doi: 10.3748/wjg.14.3360. PMID: 18528933Free PMC Article

Diagnosis

Jamee M, Alaei MR, Mesdaghi M, Noorian S, Moosavian M, Dolatshahi E, Taghavi Kojidi H, Chavoshzadeh Z, Fallahi M, Parviz S, Aghamahdi F, Azizi G
Immunol Invest 2022 May;51(4):778-786. Epub 2021 Jan 12 doi: 10.1080/08820139.2021.1872615. PMID: 33432864
Živković J, Lipej M, Banić I, Bulat Lokas S, Nogalo B, Lulić Jurjević R, Turkalj M
Scand J Immunol 2019 Dec;90(6):e12828. Epub 2019 Oct 24 doi: 10.1111/sji.12828. PMID: 31520490
Moschese V, Chini L, Graziani S, Sgrulletti M, Gallo V, Di Matteo G, Ferrari S, Di Cesare S, Cirillo E, Pession A, Pignata C, Specchia F
Eur J Pediatr 2019 Jan;178(1):51-60. Epub 2018 Sep 29 doi: 10.1007/s00431-018-3248-1. PMID: 30269248
Shakkottai A, Bupathi K, Patel AP, Chalom E, Chamarthi S, Lehman TJ, Peterson MG, Gaur S, Moorthy LN
Clin Pediatr (Phila) 2012 Jan;51(1):46-50. Epub 2011 Aug 25 doi: 10.1177/0009922811417287. PMID: 21868598
Mieli-Vergani G, Vergani D
World J Gastroenterol 2008 Jun 7;14(21):3360-7. doi: 10.3748/wjg.14.3360. PMID: 18528933Free PMC Article

Therapy

Mieli-Vergani G, Vergani D
World J Gastroenterol 2008 Jun 7;14(21):3360-7. doi: 10.3748/wjg.14.3360. PMID: 18528933Free PMC Article
van Rossum MA, Fiselier TJ, Franssen MJ, ten Cate R, van Suijlekom-Smit LW, Wulffraat NM, van Luijk WH, Oostveen JC, Kuis W, Dijkmans BA, van Soesbergen RM; Dutch Juvenile Chronic Arthritis Study group
Scand J Rheumatol 2001;30(1):25-30. doi: 10.1080/030097401750065283. PMID: 11252688
Herrod HG
Ann Allergy Asthma Immunol 1997 Nov;79(5):460-4. doi: 10.1016/S1081-1206(10)63044-X. PMID: 9396982
Coşkun Y, Sanal O, Ersoy F
Turk J Pediatr 1990 Apr-Jun;32(2):79-83. PMID: 2091374

Prognosis

Moschese V, Chini L, Graziani S, Sgrulletti M, Gallo V, Di Matteo G, Ferrari S, Di Cesare S, Cirillo E, Pession A, Pignata C, Specchia F
Eur J Pediatr 2019 Jan;178(1):51-60. Epub 2018 Sep 29 doi: 10.1007/s00431-018-3248-1. PMID: 30269248
Özcan C, Metin A, Erkoçoğlu M, Kocabas CN
Allergol Immunopathol (Madr) 2015 Jan-Feb;43(1):57-61. Epub 2014 Jan 30 doi: 10.1016/j.aller.2013.09.014. PMID: 24485938
Janzi M, Kull I, Sjöberg R, Wan J, Melén E, Bayat N, Ostblom E, Pan-Hammarström Q, Nilsson P, Hammarström L
Clin Immunol 2009 Oct;133(1):78-85. Epub 2009 Jun 21 doi: 10.1016/j.clim.2009.05.014. PMID: 19541543
Kutukculer N, Gulez N
Pediatr Allergy Immunol 2009 Nov;20(7):693-8. Epub 2009 Jan 31 doi: 10.1111/j.1399-3038.2008.00845.x. PMID: 19196447
Mieli-Vergani G, Vergani D
World J Gastroenterol 2008 Jun 7;14(21):3360-7. doi: 10.3748/wjg.14.3360. PMID: 18528933Free PMC Article

Clinical prediction guides

Jamee M, Alaei MR, Mesdaghi M, Noorian S, Moosavian M, Dolatshahi E, Taghavi Kojidi H, Chavoshzadeh Z, Fallahi M, Parviz S, Aghamahdi F, Azizi G
Immunol Invest 2022 May;51(4):778-786. Epub 2021 Jan 12 doi: 10.1080/08820139.2021.1872615. PMID: 33432864
Moschese V, Chini L, Graziani S, Sgrulletti M, Gallo V, Di Matteo G, Ferrari S, Di Cesare S, Cirillo E, Pession A, Pignata C, Specchia F
Eur J Pediatr 2019 Jan;178(1):51-60. Epub 2018 Sep 29 doi: 10.1007/s00431-018-3248-1. PMID: 30269248
Cipe FE, Doğu F, Güloğlu D, Aytekin C, Polat M, Biyikli Z, Ikincioğullari A
J Investig Allergol Clin Immunol 2013;23(2):94-100. PMID: 23654075
Shakkottai A, Bupathi K, Patel AP, Chalom E, Chamarthi S, Lehman TJ, Peterson MG, Gaur S, Moorthy LN
Clin Pediatr (Phila) 2012 Jan;51(1):46-50. Epub 2011 Aug 25 doi: 10.1177/0009922811417287. PMID: 21868598
Janzi M, Kull I, Sjöberg R, Wan J, Melén E, Bayat N, Ostblom E, Pan-Hammarström Q, Nilsson P, Hammarström L
Clin Immunol 2009 Oct;133(1):78-85. Epub 2009 Jun 21 doi: 10.1016/j.clim.2009.05.014. PMID: 19541543

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