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Abnormal corneal epithelium morphology

MedGen UID:
868915
•Concept ID:
C4023326
•
Anatomical Abnormality
Synonym: Abnormality of corneal epithelium
 
HPO: HP:0011495

Definition

Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea. [from HPO]

Professional guidelines

PubMed

The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye.
Lima Cunha D, Arno G, Corton M, Moosajee M
Genes (Basel) 2019 Dec 17;10(12) doi: 10.3390/genes10121050. PMID: 31861090Free PMC Article
Clinical results and influential factors of modified large-diameter lamellar keratoplasty in the treatment of total limbal stem cell deficiency.
Qi X, Xie L, Cheng J, Zhao J
Cornea 2013 May;32(5):555-60. doi: 10.1097/ICO.0b013e318255394e. PMID: 22580444
Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management.
Dua HS, Saini JS, Azuara-Blanco A, Gupta P
Indian J Ophthalmol 2000 Jun;48(2):83-92. PMID: 11116520

Recent clinical studies

Etiology

Association of Variants in TMEM45A With Keratoglobus.
Weiner C, Hecht I, Kotlyar A, Shoshany N, Zadok D, Elbaz U, Segev F, Maytal A, Hachmo Y, Michiels C, De Backer O, Shomron N, Einan-Lifshitz A, Pras E
JAMA Ophthalmol 2021 Oct 1;139(10):1089-1095. doi: 10.1001/jamaophthalmol.2021.3172. PMID: 34410316Free PMC Article
Ocular Involvement in Hereditary Amyloidosis.
Minnella AM, Rissotto R, Antoniazzi E, Di Girolamo M, Luigetti M, Maceroni M, Bacherini D, Falsini B, Rizzo S, Obici L
Genes (Basel) 2021 Jun 22;12(7) doi: 10.3390/genes12070955. PMID: 34206500Free PMC Article
Pathophysiology of Corneal Dystrophies: From Cellular Genetic Alteration to Clinical Findings.
Sacchetti M, Macchi I, Tiezzi A, La Cava M, Massaro-Giordano G, Lambiase A
J Cell Physiol 2016 Feb;231(2):261-9. doi: 10.1002/jcp.25082. PMID: 26104822
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Diagnosis

Ocular Involvement in Hereditary Amyloidosis.
Minnella AM, Rissotto R, Antoniazzi E, Di Girolamo M, Luigetti M, Maceroni M, Bacherini D, Falsini B, Rizzo S, Obici L
Genes (Basel) 2021 Jun 22;12(7) doi: 10.3390/genes12070955. PMID: 34206500Free PMC Article
Multifocal Vortex Keratopathy.
Tan N, Thaung C, Tuft S
Cornea 2020 Aug;39(8):1052-1054. doi: 10.1097/ICO.0000000000002285. PMID: 32073455
The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye.
Lima Cunha D, Arno G, Corton M, Moosajee M
Genes (Basel) 2019 Dec 17;10(12) doi: 10.3390/genes10121050. PMID: 31861090Free PMC Article
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Therapy

Multifocal Vortex Keratopathy.
Tan N, Thaung C, Tuft S
Cornea 2020 Aug;39(8):1052-1054. doi: 10.1097/ICO.0000000000002285. PMID: 32073455
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials.
Nath S, Shen C, Koziarz A, Banfield L, Fava MA, Hodge WG
BMJ Open 2019 May 27;9(5):e025728. doi: 10.1136/bmjopen-2018-025728. PMID: 31133582Free PMC Article
Lid wiper epitheliopathy.
Efron N, Brennan NA, Morgan PB, Wilson T
Prog Retin Eye Res 2016 Jul;53:140-174. Epub 2016 Apr 14 doi: 10.1016/j.preteyeres.2016.04.004. PMID: 27094372
Chemical injuries of the eye: current concepts in pathophysiology and therapy.
Wagoner MD
Surv Ophthalmol 1997 Jan-Feb;41(4):275-313. doi: 10.1016/s0039-6257(96)00007-0. PMID: 9104767
Recurrent corneal erosions.
Findley HM
J Am Optom Assoc 1986 May;57(5):392-6. PMID: 3486894

Prognosis

Multifocal Vortex Keratopathy.
Tan N, Thaung C, Tuft S
Cornea 2020 Aug;39(8):1052-1054. doi: 10.1097/ICO.0000000000002285. PMID: 32073455
Diagnosis of corneal limbal stem cell deficiency.
Kim KH, Mian SI
Curr Opin Ophthalmol 2017 Jul;28(4):355-362. doi: 10.1097/ICU.0000000000000387. PMID: 28426441
Corneal dystrophies.
Klintworth GK
Orphanet J Rare Dis 2009 Feb 23;4:7. doi: 10.1186/1750-1172-4-7. PMID: 19236704Free PMC Article
Clinical features of the congenital vitreoretinopathies.
Edwards AO
Eye (Lond) 2008 Oct;22(10):1233-42. Epub 2008 Feb 29 doi: 10.1038/eye.2008.38. PMID: 18309337
Exfoliation syndrome.
Ritch R, Schlötzer-Schrehardt U
Surv Ophthalmol 2001 Jan-Feb;45(4):265-315. doi: 10.1016/s0039-6257(00)00196-x. PMID: 11166342

Clinical prediction guides

Mucolipidosis type IV in a child.
Chaer L, Harissi-Dagher M, Soucy JF, Ellezam B, Hamel P
J AAPOS 2018 Dec;22(6):469-471. Epub 2018 Aug 16 doi: 10.1016/j.jaapos.2018.04.011. PMID: 30120981
Abnormal Anterior Corneal Morphology in Diabetes Observed Using In Vivo Laser-scanning Confocal Microscopy.
Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N
Ocul Surf 2016 Oct;14(4):507-514. Epub 2016 Aug 20 doi: 10.1016/j.jtos.2016.07.004. PMID: 27555566
Lid wiper epitheliopathy.
Efron N, Brennan NA, Morgan PB, Wilson T
Prog Retin Eye Res 2016 Jul;53:140-174. Epub 2016 Apr 14 doi: 10.1016/j.preteyeres.2016.04.004. PMID: 27094372
Pathologic epithelial and anterior corneal nerve morphology in early-stage congenital aniridic keratopathy.
Edén U, Fagerholm P, Danyali R, Lagali N
Ophthalmology 2012 Sep;119(9):1803-10. Epub 2012 Apr 17 doi: 10.1016/j.ophtha.2012.02.043. PMID: 22512983
Patterns of superficial keratopathy.
Roussel T, Grutzmacher R, Coster D
Aust J Ophthalmol 1984 Nov;12(4):301-16. doi: 10.1111/j.1442-9071.1984.tb01174.x. PMID: 6442135

Recent systematic reviews

Tears and Eyewear in Forensic Investigation-A Review.
Aparna R, Shanti Iyer R
Forensic Sci Int 2020 Jan;306:110055. Epub 2019 Nov 15 doi: 10.1016/j.forsciint.2019.110055. PMID: 31785512

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