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Central opacification of the cornea

MedGen UID:
868916
Concept ID:
C4023327
Finding
HPO: HP:0011493

Definition

Reduced transparency of the central portion of the corneal stroma. [from HPO]

Professional guidelines

PubMed

Weiss JS, Khemichian AJ
Dev Ophthalmol 2011;48:67-96. Epub 2011 Apr 26 doi: 10.1159/000324078. PMID: 21540632

Recent clinical studies

Etiology

Nagpal R, Goyal RB, Priyadarshini K, Kashyap S, Sharma M, Sinha R, Sharma N
Indian J Ophthalmol 2022 Jul;70(7):2249-2261. doi: 10.4103/ijo.IJO_425_22. PMID: 35791104Free PMC Article
Raber IM, Eagle RC Jr
Cornea 2022 Feb 1;41(2):183-191. doi: 10.1097/ICO.0000000000002716. PMID: 34620763
Salik I, Gupta A, Tara A, Zaidman G, Barst S
Paediatr Anaesth 2020 May;30(5):577-583. Epub 2020 Mar 16 doi: 10.1111/pan.13843. PMID: 32107814
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Akpek EK, Alkharashi M, Hwang FS, Ng SM, Lindsley K
Cochrane Database Syst Rev 2014 Nov 5;11(11):CD009561. doi: 10.1002/14651858.CD009561.pub2. PMID: 25372407Free PMC Article

Diagnosis

Nagpal R, Goyal RB, Priyadarshini K, Kashyap S, Sharma M, Sinha R, Sharma N
Indian J Ophthalmol 2022 Jul;70(7):2249-2261. doi: 10.4103/ijo.IJO_425_22. PMID: 35791104Free PMC Article
Raber IM, Eagle RC Jr
Cornea 2022 Feb 1;41(2):183-191. doi: 10.1097/ICO.0000000000002716. PMID: 34620763
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Rajak SN, Habtamu E, Weiss HA, Bedri A, Gebre T, Genet A, Khaw PT, Bailey RL, Mabey DC, Gilbert CE, Emerson PM, Burton MJ
Ophthalmology 2012 Jan;119(1):84-9. Epub 2011 Oct 5 doi: 10.1016/j.ophtha.2011.06.045. PMID: 21975041Free PMC Article
Weiss JS, Khemichian AJ
Dev Ophthalmol 2011;48:67-96. Epub 2011 Apr 26 doi: 10.1159/000324078. PMID: 21540632

Therapy

Chen M, Ng SM, Akpek EK, Ahmad S
Cochrane Database Syst Rev 2020 May 13;5(5):CD009561. doi: 10.1002/14651858.CD009561.pub3. PMID: 32408386Free PMC Article
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Jiang G, Fan T
Oxid Med Cell Longev 2018;2018:4967318. Epub 2018 Jul 8 doi: 10.1155/2018/4967318. PMID: 30116483Free PMC Article
Akpek EK, Alkharashi M, Hwang FS, Ng SM, Lindsley K
Cochrane Database Syst Rev 2014 Nov 5;11(11):CD009561. doi: 10.1002/14651858.CD009561.pub2. PMID: 25372407Free PMC Article
Rajak SN, Habtamu E, Weiss HA, Bedri A, Gebre T, Genet A, Khaw PT, Bailey RL, Mabey DC, Gilbert CE, Emerson PM, Burton MJ
Ophthalmology 2012 Jan;119(1):84-9. Epub 2011 Oct 5 doi: 10.1016/j.ophtha.2011.06.045. PMID: 21975041Free PMC Article

Prognosis

Yim CK, Zhu D
Cornea 2022 May 1;41(5):640-643. doi: 10.1097/ICO.0000000000002890. PMID: 35383619
Raber IM, Eagle RC Jr
Cornea 2022 Feb 1;41(2):183-191. doi: 10.1097/ICO.0000000000002716. PMID: 34620763
Das AV, Basu S
Br J Ophthalmol 2021 Jan;105(1):17-21. Epub 2020 Mar 18 doi: 10.1136/bjophthalmol-2019-315361. PMID: 32188677
Lang SJ, Böhringer D, Geerling G, Reinhard T
Eye (Lond) 2017 Mar;31(3):372-378. Epub 2016 Oct 21 doi: 10.1038/eye.2016.217. PMID: 27768117Free PMC Article
Weiss JS, Khemichian AJ
Dev Ophthalmol 2011;48:67-96. Epub 2011 Apr 26 doi: 10.1159/000324078. PMID: 21540632

Clinical prediction guides

Damala M, Sahoo A, Pakalapati N, Singh V, Basu S
Cells 2023 Mar 11;12(6) doi: 10.3390/cells12060876. PMID: 36980217Free PMC Article
Franco E, Iqbal N, Shah PR, Alabek M, Tripi KS, Prescott C, Scanga HL, Chu CT, Nischal KK
Cornea 2023 Mar 1;42(3):344-350. Epub 2022 Nov 30 doi: 10.1097/ICO.0000000000003155. PMID: 36455075
Akpek EK, Alkharashi M, Hwang FS, Ng SM, Lindsley K
Cochrane Database Syst Rev 2014 Nov 5;11(11):CD009561. doi: 10.1002/14651858.CD009561.pub2. PMID: 25372407Free PMC Article
Weiss JS, Khemichian AJ
Dev Ophthalmol 2011;48:67-96. Epub 2011 Apr 26 doi: 10.1159/000324078. PMID: 21540632
Kivelä T, Uusitalo M
Prog Retin Eye Res 1998 Jul;17(3):385-428. doi: 10.1016/s1350-9462(98)00001-9. PMID: 9695798

Recent systematic reviews

Chen M, Ng SM, Akpek EK, Ahmad S
Cochrane Database Syst Rev 2020 May 13;5(5):CD009561. doi: 10.1002/14651858.CD009561.pub3. PMID: 32408386Free PMC Article
Akpek EK, Alkharashi M, Hwang FS, Ng SM, Lindsley K
Cochrane Database Syst Rev 2014 Nov 5;11(11):CD009561. doi: 10.1002/14651858.CD009561.pub2. PMID: 25372407Free PMC Article

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