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Abnormal malleus morphology

MedGen UID:
868936
•Concept ID:
C4023349
•
Anatomical Abnormality
Synonym: Abnormality of the malleus
 
HPO: HP:0011454

Definition

An abnormality of the malleus, an ossicle in the middle ear. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal malleus morphology

Conditions with this feature

Thickened earlobes-conductive deafness syndrome
MedGen UID:
343676
•Concept ID:
C1851896
•
Finding
Thickened earlobes-conductive deafness syndrome is characterized by microtia with thickened ear lobes, micrognathia and conductive hearing loss due to congenital ossicular anomalies. It has been described in two families. The mode of inheritance is autosomal dominant.
See: Condition Record
Thickened earlobes-conductive deafness syndrome

Recent clinical studies

Etiology

The "boomerang" malleus-incus complex in congenital aural atresia.
Mukherjee S, Kesser BW, Raghavan P
AJNR Am J Neuroradiol 2014 Nov-Dec;35(11):2181-5. Epub 2014 Jul 3 doi: 10.3174/ajnr.A4022. PMID: 24994825Free PMC Article
Anomalous facial nerve in congenital stapes fixation.
An YS, Lee JH, Lee KS
Otol Neurotol 2014 Apr;35(4):662-6. doi: 10.1097/MAO.0000000000000318. PMID: 24622020
Surgery of idiopathic malleus fixation.
Martin C, Oletski A, Prades JM
Otol Neurotol 2009 Feb;30(2):165-9. doi: 10.1097/mao.0b013e318191a66d. PMID: 19180677
Clinical-histopathological correlations of pitfalls in middle ear surgery.
Mutlu C, da Costa SS, Paparella MM, Schachern PA
Eur Arch Otorhinolaryngol 1998;255(4):189-94. doi: 10.1007/s004050050041. PMID: 9592676
Surgery for congenital stapes ankylosis with an associated congenital ossicular chain anomaly.
Teunissen B, Cremers CW
Int J Pediatr Otorhinolaryngol 1991 May;21(3):217-26. doi: 10.1016/0165-5876(91)90003-t. PMID: 1869375

Diagnosis

Goodhill syndrome: a case report.
El Youbi ABA, Alami M, Benmansour N, El Alami El Amine MN
Pan Afr Med J 2024;47:168. Epub 2024 Apr 5 doi: 10.11604/pamj.2024.47.168.43187. PMID: 39036014Free PMC Article
The morphological findings of malleus and incus in a case of Marfan's syndrome.
Evcimik MF, Ozkurt FE, Karavus A, Sapci T
Laryngoscope 2012 Feb;122(2):389-92. Epub 2012 Jan 17 doi: 10.1002/lary.22400. PMID: 22252411
Congenital bony fixation of the malleus.
Subotic R, Mladina R, Risavi R
Acta Otolaryngol 1998 Nov;118(6):833-6. doi: 10.1080/00016489850182530. PMID: 9870629
Hearing loss in Noonan syndrome.
Cremers CW, van der Burgt CJ
Int J Pediatr Otorhinolaryngol 1992 Jan;23(1):81-4. doi: 10.1016/0165-5876(92)90082-z. PMID: 1592554
Surgery for congenital stapes ankylosis with an associated congenital ossicular chain anomaly.
Teunissen B, Cremers CW
Int J Pediatr Otorhinolaryngol 1991 May;21(3):217-26. doi: 10.1016/0165-5876(91)90003-t. PMID: 1869375

Therapy

Bilateral Ossicular Head Dehiscence Into the Middle Cranial Fossa.
Alvi SA, Jones JW, Lin J
Ann Otol Rhinol Laryngol 2018 Mar;127(3):209-212. Epub 2018 Jan 9 doi: 10.1177/0003489417751956. PMID: 29313370
Temporal bone pathology in fetuses exposed to isotretinoin.
Moerike S, Pantzar JT, De Sa D
Pediatr Dev Pathol 2002 Jul-Aug;5(4):405-9. Epub 2002 May 21 doi: 10.1007/s10024-001-0258-0. PMID: 12016535
Middle ear anomalies induced by hypertriazene administration in the mouse.
Takeda Y, Nishizaki K, Masuda Y, Watanabe S
Auris Nasus Larynx 1996;23:1-12. doi: 10.1016/s0385-8146(96)80002-2. PMID: 8809317
Use of the argon laser in the treatment of malleus fixation.
Sands CJ, Napolitano N
Arch Otolaryngol Head Neck Surg 1990 Aug;116(8):975-6. doi: 10.1001/archotol.1990.01870080097026. PMID: 2378729
Homograft (allograft) tympanoplasty update.
Lesinski SG
Laryngoscope 1986 Nov;96(11):1211-20. doi: 10.1002/lary.1986.96.11.1211. PMID: 3773619

Prognosis

Anomalous facial nerve in congenital stapes fixation.
An YS, Lee JH, Lee KS
Otol Neurotol 2014 Apr;35(4):662-6. doi: 10.1097/MAO.0000000000000318. PMID: 24622020
The morphological findings of malleus and incus in a case of Marfan's syndrome.
Evcimik MF, Ozkurt FE, Karavus A, Sapci T
Laryngoscope 2012 Feb;122(2):389-92. Epub 2012 Jan 17 doi: 10.1002/lary.22400. PMID: 22252411
Surgery of idiopathic malleus fixation.
Martin C, Oletski A, Prades JM
Otol Neurotol 2009 Feb;30(2):165-9. doi: 10.1097/mao.0b013e318191a66d. PMID: 19180677
Surgery for congenital stapes ankylosis with an associated congenital ossicular chain anomaly.
Teunissen B, Cremers CW
Int J Pediatr Otorhinolaryngol 1991 May;21(3):217-26. doi: 10.1016/0165-5876(91)90003-t. PMID: 1869375
Treacher Collins syndrome: an otologic challenge.
Jahrsdoerfer RA, Aguilar EA, Yeakley JW, Cole RR
Ann Otol Rhinol Laryngol 1989 Oct;98(10):807-12. doi: 10.1177/000348948909801011. PMID: 2802464

Clinical prediction guides

Favorable prognostic factors for long-term postoperative hearing results after canal tympanoplasty for congenital aural stenosis.
Sakamoto T, Kikkawa YS, Kikuta S, Kinoshita M, Ueha R, Suzukawa K, Kashio A, Kakigi A, Ito K, Suzuki M, Yamasoba T
Otol Neurotol 2014 Jul;35(6):966-71. doi: 10.1097/MAO.0000000000000335. PMID: 24781102
Key features of the human middle ear.
Hudde H, Weistenhofer C
ORL J Otorhinolaryngol Relat Spec 2006;68(6):324-8. Epub 2006 Oct 26 doi: 10.1159/000095274. PMID: 17065824
Histopathological basis of hearing impairment in Wolf-Hirschhorn syndrome.
Ulualp SO, Wright CG, Pawlowski KS, Roland PS
Laryngoscope 2004 Aug;114(8):1426-30. doi: 10.1097/00005537-200408000-00021. PMID: 15280721
Surgical treatment of 52 cases of auditory ossicular malformations.
Hashimoto S, Yamamoto Y, Satoh H, Takahashi S
Auris Nasus Larynx 2002 Jan;29(1):15-8. doi: 10.1016/s0385-8146(01)00125-0. PMID: 11772485
Treacher Collins syndrome: an otologic challenge.
Jahrsdoerfer RA, Aguilar EA, Yeakley JW, Cole RR
Ann Otol Rhinol Laryngol 1989 Oct;98(10):807-12. doi: 10.1177/000348948909801011. PMID: 2802464

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