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Fetal ultrasound soft marker

MedGen UID:
868952
Concept ID:
C4023366
Finding
Synonym: Foetal ultrasound soft marker
 
HPO: HP:0011425

Definition

An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal ultrasound soft marker

Professional guidelines

PubMed

Lourenço CSFP, Carriço AL, Valente FMDS
Rev Bras Ginecol Obstet 2021 Jun;43(6):452-456. Epub 2021 Jul 27 doi: 10.1055/s-0041-1732461. PMID: 34318470Free PMC Article
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Prabhu M, Kuller JA, Biggio JR
Am J Obstet Gynecol 2021 Oct;225(4):B2-B15. Epub 2021 Jun 23 doi: 10.1016/j.ajog.2021.06.079. PMID: 34171388
Expert Panel on GYN and OB Imaging, Sussman BL, Chopra P, Poder L, Bulas DI, Burger I, Feldstein VA, Laifer-Narin SL, Oliver ER, Strachowski LM, Wang EY, Winter T, Zelop CM, Glanc P
J Am Coll Radiol 2021 May;18(5S):S189-S198. doi: 10.1016/j.jacr.2021.02.017. PMID: 33958112

Recent clinical studies

Etiology

Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Prabhu M, Kuller JA, Biggio JR
Am J Obstet Gynecol 2021 Oct;225(4):B2-B15. Epub 2021 Jun 23 doi: 10.1016/j.ajog.2021.06.079. PMID: 34171388
Norton ME
Semin Perinatol 2013 Oct;37(5):365-9. doi: 10.1053/j.semperi.2013.06.015. PMID: 24176161
Rodriguez R, Herrero B, Bartha JL
Curr Opin Obstet Gynecol 2013 Apr;25(2):145-51. doi: 10.1097/GCO.0b013e32835e14eb. PMID: 23340246
Filkins K, Koos BJ
Curr Opin Obstet Gynecol 2005 Apr;17(2):185-95. doi: 10.1097/01.gco.0000162190.83972.5a. PMID: 15758613

Diagnosis

Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Prabhu M, Kuller JA, Biggio JR
Am J Obstet Gynecol 2021 Oct;225(4):B2-B15. Epub 2021 Jun 23 doi: 10.1016/j.ajog.2021.06.079. PMID: 34171388
Yoshizato T, Kozuma Y, Horinouchi T, Shinagawa T, Yokomine M, Ushijima K
Kurume Med J 2021 Jul 21;66(2):85-92. Epub 2021 Jun 15 doi: 10.2739/kurumemedj.MS662002. PMID: 34135197
Kaplan R, Adams S
J Midwifery Womens Health 2018 May;63(3):323-329. Epub 2018 May 15 doi: 10.1111/jmwh.12754. PMID: 29763964
Maruotti GM, Saccone G, Martinelli P
J Matern Fetal Neonatal Med 2017 Apr;30(8):972-976. Epub 2016 Jun 13 doi: 10.1080/14767058.2016.1193144. PMID: 27294775
Filkins K, Koos BJ
Curr Opin Obstet Gynecol 2005 Apr;17(2):185-95. doi: 10.1097/01.gco.0000162190.83972.5a. PMID: 15758613

Therapy

Garcia Flores J, Mogra R, Sadowski M, Hyett J
Fetal Diagn Ther 2021;48(3):201-208. Epub 2021 Mar 3 doi: 10.1159/000510637. PMID: 33657569
Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Lopez A, Dorronsoro I, Tamarit I, Sainz De La Cuesta R
Prenat Diagn 2015 Dec;35(12):1187-96. Epub 2015 Sep 3 doi: 10.1002/pd.4669. PMID: 26256264
Orzechowski KM, Berghella V
Ultrasound Obstet Gynecol 2013 Dec;42(6):615-21. Epub 2013 Oct 27 doi: 10.1002/uog.12516. PMID: 23712390
Viaux-Savelon S, Dommergues M, Rosenblum O, Bodeau N, Aidane E, Philippon O, Mazet P, Vibert-Guigue C, Vauthier-Brouzes D, Feldman R, Cohen D
PLoS One 2012;7(1):e30935. Epub 2012 Jan 23 doi: 10.1371/journal.pone.0030935. PMID: 22292077Free PMC Article
Gagnon A; GENETICS COMMITTEE
J Obstet Gynaecol Can 2009 Sep;31(9):875-881. doi: 10.1016/S1701-2163(16)34307-9. PMID: 19941713

Prognosis

Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Yoshizato T, Kozuma Y, Horinouchi T, Shinagawa T, Yokomine M, Ushijima K
Kurume Med J 2021 Jul 21;66(2):85-92. Epub 2021 Jun 15 doi: 10.2739/kurumemedj.MS662002. PMID: 34135197
Maruotti GM, Saccone G, Martinelli P
J Matern Fetal Neonatal Med 2017 Apr;30(8):972-976. Epub 2016 Jun 13 doi: 10.1080/14767058.2016.1193144. PMID: 27294775
Stefanovic V
Curr Opin Obstet Gynecol 2015 Apr;27(2):151-8. doi: 10.1097/GCO.0000000000000157. PMID: 25689239
Witters I, Fryns JR
Genet Couns 2007;18(1):1-7. PMID: 17515296

Clinical prediction guides

Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Hu R, Huang W, Zhou W, Luo X, Ren C, Huang H, Hou Y, Guo L, He W, Lu J
Hum Genomics 2022 Dec 1;16(1):64. doi: 10.1186/s40246-022-00438-4. PMID: 36457118Free PMC Article
Yoshizato T, Kozuma Y, Horinouchi T, Shinagawa T, Yokomine M, Ushijima K
Kurume Med J 2021 Jul 21;66(2):85-92. Epub 2021 Jun 15 doi: 10.2739/kurumemedj.MS662002. PMID: 34135197
Garcia Flores J, Mogra R, Sadowski M, Hyett J
Fetal Diagn Ther 2021;48(3):201-208. Epub 2021 Mar 3 doi: 10.1159/000510637. PMID: 33657569
Maruotti GM, Saccone G, Martinelli P
J Matern Fetal Neonatal Med 2017 Apr;30(8):972-976. Epub 2016 Jun 13 doi: 10.1080/14767058.2016.1193144. PMID: 27294775

Recent systematic reviews

Sagi-Dain L, Singer A, Josefsberg S, Peleg A, Lev D, Samra NN, Bar-Shira A, Zeligson S, Maya I, Ben-Shachar S
Ultrasound Obstet Gynecol 2019 Jun;53(6):810-815. doi: 10.1002/uog.20208. PMID: 30584678

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