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Abnormal blood chloride concentration

MedGen UID:
868953
•Concept ID:
C4023367
•
Finding
Synonyms: Abnormal blood Cl concentration; Abnormal blood Cl- concentration; Abnormality of chloride homeostasis
 
HPO: HP:0011422

Definition

An abnormality of chloride homeostasis or concentration in the body. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal blood chloride concentration

Professional guidelines

PubMed

Pathophysiologically based drug treatment of sickle cell disease.
Steinberg MH
Trends Pharmacol Sci 2006 Apr;27(4):204-10. Epub 2006 Mar 13 doi: 10.1016/j.tips.2006.02.007. PMID: 16530854
Thiazide diuretic prescription and electrolyte abnormalities in primary care.
Clayton JA, Rodgers S, Blakey J, Avery A, Hall IP
Br J Clin Pharmacol 2006 Jan;61(1):87-95. doi: 10.1111/j.1365-2125.2005.02531.x. PMID: 16390355Free PMC Article
Advances in the diagnosis and management of cystic fibrosis.
Blythe SA, Farrell PM
Clin Biochem 1984 Oct;17(5):277-83. doi: 10.1016/s0009-9120(84)90541-1. PMID: 6388902

Recent clinical studies

Etiology

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
López-Briz E, Ruiz Garcia V, Cabello JB, Bort-Martí S, Carbonell Sanchis R
Cochrane Database Syst Rev 2022 Jul 18;7(7):CD008462. doi: 10.1002/14651858.CD008462.pub4. PMID: 35849083Free PMC Article
Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis.
Glaser NS, Stoner MJ, Garro A, Baird S, Myers SR, Rewers A, Brown KM, Trainor JL, Quayle KS, McManemy JK, DePiero AD, Nigrovic LE, Tzimenatos L, Schunk JE, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group
Pediatrics 2021 Sep;148(3) Epub 2021 Aug 9 doi: 10.1542/peds.2021-050243. PMID: 34373322
Ab-normal saline in abnormal kidney function: risks and alternatives.
Hayes W
Pediatr Nephrol 2019 Jul;34(7):1191-1199. Epub 2018 Jul 9 doi: 10.1007/s00467-018-4008-1. PMID: 29987459Free PMC Article
Electrolyte changes in stroke.
Alam MN, Uddin MJ, Rahman KM, Ahmed S, Akhter M, Nahar N, Swapan MK, Alam MM, Sultana N, Hallaz MM, Alam MM, Uddin MM, Bari MS, Israil MA
Mymensingh Med J 2012 Oct;21(4):594-9. PMID: 23134903
Cystic fibrosis.
Radlović N
Srp Arh Celok Lek 2012 Mar-Apr;140(3-4):244-9. PMID: 22650116

Diagnosis

Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis.
Glaser NS, Stoner MJ, Garro A, Baird S, Myers SR, Rewers A, Brown KM, Trainor JL, Quayle KS, McManemy JK, DePiero AD, Nigrovic LE, Tzimenatos L, Schunk JE, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group
Pediatrics 2021 Sep;148(3) Epub 2021 Aug 9 doi: 10.1542/peds.2021-050243. PMID: 34373322
Metabolic Alkalosis: A Brief Pathophysiologic Review.
Emmett M
Clin J Am Soc Nephrol 2020 Dec 7;15(12):1848-1856. Epub 2020 Jun 25 doi: 10.2215/CJN.16041219. PMID: 32586924Free PMC Article
Update on neonatal hypoglycemia.
Rozance PJ
Curr Opin Endocrinol Diabetes Obes 2014 Feb;21(1):45-50. doi: 10.1097/MED.0000000000000027. PMID: 24275620Free PMC Article
Neurogenic and sympathoexcitatory actions of NaCl in hypertension.
Stocker SD, Monahan KD, Browning KN
Curr Hypertens Rep 2013 Dec;15(6):538-46. doi: 10.1007/s11906-013-0385-9. PMID: 24052211Free PMC Article
Cystic fibrosis.
Radlović N
Srp Arh Celok Lek 2012 Mar-Apr;140(3-4):244-9. PMID: 22650116

Therapy

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
López-Briz E, Ruiz Garcia V, Cabello JB, Bort-Martí S, Carbonell Sanchis R
Cochrane Database Syst Rev 2022 Jul 18;7(7):CD008462. doi: 10.1002/14651858.CD008462.pub4. PMID: 35849083Free PMC Article
Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis.
Glaser NS, Stoner MJ, Garro A, Baird S, Myers SR, Rewers A, Brown KM, Trainor JL, Quayle KS, McManemy JK, DePiero AD, Nigrovic LE, Tzimenatos L, Schunk JE, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group
Pediatrics 2021 Sep;148(3) Epub 2021 Aug 9 doi: 10.1542/peds.2021-050243. PMID: 34373322
Ab-normal saline in abnormal kidney function: risks and alternatives.
Hayes W
Pediatr Nephrol 2019 Jul;34(7):1191-1199. Epub 2018 Jul 9 doi: 10.1007/s00467-018-4008-1. PMID: 29987459Free PMC Article
Neurogenic and sympathoexcitatory actions of NaCl in hypertension.
Stocker SD, Monahan KD, Browning KN
Curr Hypertens Rep 2013 Dec;15(6):538-46. doi: 10.1007/s11906-013-0385-9. PMID: 24052211Free PMC Article
Bench-to-bedside review: Chloride in critical illness.
Yunos NM, Bellomo R, Story D, Kellum J
Crit Care 2010;14(4):226. Epub 2010 Jul 8 doi: 10.1186/cc9052. PMID: 20663180Free PMC Article

Prognosis

Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study.
Penfold JA, Wells CI, Du P, Qian A, Vather R, Bissett IP, O'Grady G
Physiol Rep 2021 Feb;9(3):e14735. doi: 10.14814/phy2.14735. PMID: 33527737Free PMC Article
Clinical Analysis of Electrolyte Disorders in Patients with Diabetic Ketoacidosis.
Su D, Li J, Guo M, Li Y, Ma S
Clin Lab 2021 Jan 1;67(1) doi: 10.7754/Clin.Lab.2020.200309. PMID: 33491430
Metabolic Alkalosis: A Brief Pathophysiologic Review.
Emmett M
Clin J Am Soc Nephrol 2020 Dec 7;15(12):1848-1856. Epub 2020 Jun 25 doi: 10.2215/CJN.16041219. PMID: 32586924Free PMC Article
Hyperchloremia Is Not an Independent Risk Factor for Postoperative Acute Kidney Injury in Pediatric Cardiac Patients.
Kimura S, Iwasaki T, Shimizu K, Kanazawa T, Kawase H, Shioji N, Kuroe Y, Matsuoka Y, Isoyama S, Morimatsu H
J Cardiothorac Vasc Anesth 2019 Jul;33(7):1939-1945. Epub 2018 Dec 5 doi: 10.1053/j.jvca.2018.12.009. PMID: 30638924
The electrolytes in hyponatremia.
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285

Clinical prediction guides

MRI manifestations of central nervous system leukaemia and cytological analysis of the cerebrospinal fluid.
Yi H, Liu K, Yang W, Li Y, Wang X, Zhang T, Liu C, Li Y, Mi Y
Clin Radiol 2023 Sep;78(9):e613-e619. Epub 2023 Jun 1 doi: 10.1016/j.crad.2023.04.016. PMID: 37330321
Predictors of methacholine challenge testing results in subjects without airflow obstruction.
Chevrier S, Abdulnour J, Saint-Pierre MD
J Asthma 2022 Oct;59(10):2060-2068. Epub 2021 Oct 9 doi: 10.1080/02770903.2021.1986838. PMID: 34570662
Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis.
Glaser NS, Stoner MJ, Garro A, Baird S, Myers SR, Rewers A, Brown KM, Trainor JL, Quayle KS, McManemy JK, DePiero AD, Nigrovic LE, Tzimenatos L, Schunk JE, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group
Pediatrics 2021 Sep;148(3) Epub 2021 Aug 9 doi: 10.1542/peds.2021-050243. PMID: 34373322
Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study.
Penfold JA, Wells CI, Du P, Qian A, Vather R, Bissett IP, O'Grady G
Physiol Rep 2021 Feb;9(3):e14735. doi: 10.14814/phy2.14735. PMID: 33527737Free PMC Article
The electrolytes in hyponatremia.
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285

Recent systematic reviews

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
López-Briz E, Ruiz Garcia V, Cabello JB, Bort-Martí S, Carbonell Sanchis R
Cochrane Database Syst Rev 2022 Jul 18;7(7):CD008462. doi: 10.1002/14651858.CD008462.pub4. PMID: 35849083Free PMC Article

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