U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Moderate intrauterine growth retardation

MedGen UID:
868956
•Concept ID:
C4023370
•
Finding
HPO: HP:0011408

Definition

Intrauterine growth retardation that is at least 3 standard deviations (SD) below average, but not as low as 4 SD, corrected for sex and gestational age. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate intrauterine growth retardation

Professional guidelines

PubMed

Neonatal hyponatremia: differential diagnosis and treatment.
Marcialis MA, Dessi A, Pintus MC, Irmesi R, Fanos V
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:75-9. doi: 10.3109/14767058.2011.607667. PMID: 21942597
Primary, secondary, and tertiary prevention of pre-eclampsia.
Dekker G, Sibai B
Lancet 2001 Jan 20;357(9251):209-15. doi: 10.1016/S0140-6736(00)03599-6. PMID: 11213110
Comparative risk-benefit assessment of drugs used in the management of hypertension in pregnancy.
Kyle PM, Redman CW
Drug Saf 1992 May-Jun;7(3):223-34. doi: 10.2165/00002018-199207030-00007. PMID: 1503669

Recent clinical studies

Etiology

Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?
Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN
Cold Spring Harb Mol Case Stud 2018 Aug;4(4) Epub 2018 Aug 1 doi: 10.1101/mcs.a002899. PMID: 29802153Free PMC Article
A consideration of height as a function of prepregnancy nutritional background and its potential influence on birth weight.
Luke B, Jonaitis MA, Petrie RH
J Am Diet Assoc 1984 Feb;84(2):176-81. PMID: 6693688

Diagnosis

Reanalysis of a novel variant in the IGF1R gene in a family with variable prenatal and postnatal growth retardation and dysmorphic features: benefits and feasibility of IUSM-URDC (Undiagnosed Rare Disease Clinic) program.
Jacobs A, Burns C, Patel P, Treat K, Helm BM, Conboy E, Vetrini F
Cold Spring Harb Mol Case Stud 2022 Feb;8(2) Epub 2022 Mar 24 doi: 10.1101/mcs.a006170. PMID: 35091507Free PMC Article
Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?
Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN
Cold Spring Harb Mol Case Stud 2018 Aug;4(4) Epub 2018 Aug 1 doi: 10.1101/mcs.a002899. PMID: 29802153Free PMC Article
Maternal tetrahydrobiopterin deficiency: the course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Giżewska M, Hnatyszyn G, Sagan L, Cyryłowski L, Zekanowski C, Modrzejewska M, Nestorowicz B, Kubalska J, Walczak M
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S83-9. Epub 2009 Mar 30 doi: 10.1007/s10545-009-1073-4. PMID: 19322676

Therapy

Maternal tetrahydrobiopterin deficiency: the course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Giżewska M, Hnatyszyn G, Sagan L, Cyryłowski L, Zekanowski C, Modrzejewska M, Nestorowicz B, Kubalska J, Walczak M
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S83-9. Epub 2009 Mar 30 doi: 10.1007/s10545-009-1073-4. PMID: 19322676
Metabolic differences between AGA-and SGA-infants of very low birthweight. III. Influence of postnatal age.
Boehm G, Senger H, Müller D, Beyreiss K, Räihä NC
Acta Paediatr Scand 1989 Sep;78(5):677-81. doi: 10.1111/j.1651-2227.1989.tb11125.x. PMID: 2596273

Prognosis

Maternal tetrahydrobiopterin deficiency: the course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Giżewska M, Hnatyszyn G, Sagan L, Cyryłowski L, Zekanowski C, Modrzejewska M, Nestorowicz B, Kubalska J, Walczak M
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S83-9. Epub 2009 Mar 30 doi: 10.1007/s10545-009-1073-4. PMID: 19322676

Clinical prediction guides

Metabolic differences between AGA-and SGA-infants of very low birthweight. III. Influence of postnatal age.
Boehm G, Senger H, Müller D, Beyreiss K, Räihä NC
Acta Paediatr Scand 1989 Sep;78(5):677-81. doi: 10.1111/j.1651-2227.1989.tb11125.x. PMID: 2596273

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...