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Abnormal sixth cranial nerve morphology

MedGen UID:
868989
•Concept ID:
C4023404
•
Anatomical Abnormality
Synonyms: Abnormal abducens nerve morphology; Abnormality of the sixth cranial nerve
 
HPO: HP:0011348

Definition

Any structural abnormality of the abducens nerve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal sixth cranial nerve morphology

Professional guidelines

PubMed

Novel Segmentation of Placed Coils in the Treatment of Cavernous Sinus Dural Arteriovenous Fistulas Provides a Reliable Predictor of the Long-Term Outcome in Abducens Nerve Palsy.
Kohta M, Fujita A, Tanaka J, Sasayama T, Hosoda K, Kohmura E
World Neurosurg 2018 May;113:e38-e44. Epub 2018 Mar 7 doi: 10.1016/j.wneu.2018.01.136. PMID: 29408345
Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements.
Leigh RJ, Ramat S
Curr Opin Neurol 1999 Feb;12(1):21-7. doi: 10.1097/00019052-199902000-00004. PMID: 10097880
Gaucher disease--Norrbottnian type (III). Neuropaediatric and neurobiological aspects of clinical patterns and treatment.
Erikson A
Acta Paediatr Scand Suppl 1986;326:1-42. PMID: 3296644

Recent clinical studies

Etiology

Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Cranial nerve injuries in Le Fort I osteotomy: a systematic review.
Dos Santos Alves JM, de Freitas Alves BW, de Figueiredo Costa AC, Carneiro BGDS, de Sousa LM, Gondim DV
Int J Oral Maxillofac Surg 2019 May;48(5):601-611. Epub 2018 Dec 28 doi: 10.1016/j.ijom.2018.11.012. PMID: 30598335
Magnetic resonance imaging of developmental facial paresis: a spectrum of complex anomalies.
Mohammad SA, Abdelaziz TT, Gadelhak MI, Afifi HH, Abdel-Salam GMH
Neuroradiology 2018 Oct;60(10):1053-1061. Epub 2018 Aug 3 doi: 10.1007/s00234-018-2063-8. PMID: 30074067
Syringobulbia in pediatric patients with Chiari malformation type I.
Menezes AH, Greenlee JDW, Dlouhy BJ
J Neurosurg Pediatr 2018 Jul;22(1):52-60. Epub 2018 Apr 27 doi: 10.3171/2018.1.PEDS17472. PMID: 29701558
Nuclear and infranuclear disorders.
Meienberg O, Müri R
Baillieres Clin Neurol 1992 Aug;1(2):417-34. PMID: 1344077

Diagnosis

Vertebrobasilar dolichoectasia and other arterial abnormalities leading to abducens nerve palsy.
Aggarwal A, Kalra G, Caplan LR
J Stroke Cerebrovasc Dis 2023 May;32(5):107051. Epub 2023 Mar 3 doi: 10.1016/j.jstrokecerebrovasdis.2023.107051. PMID: 36871438
Congenital isolated unilateral third nerve palsy in children: the diagnostic contribution of high-resolution MR imaging.
Arrigoni F, Rombetto L, Redaelli D, Mancarella G, Polenghi F, Salati R, Romaniello R, Peruzzo D, Bianchi PE, Piozzi E, Mazza M, Magli A
Neuroradiology 2023 Apr;65(4):865-870. Epub 2022 Dec 29 doi: 10.1007/s00234-022-03106-5. PMID: 36580093
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Variable synergistic divergence.
Kim JH, Hwang JM
Optom Vis Sci 2009 Dec;86(12):1386-8. doi: 10.1097/OPX.0b013e3181be9db3. PMID: 19826317
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Therapy

Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy.
Dryden MS, Saeed K, Ogborn S, Swales P
Epidemiol Infect 2015 Feb;143(3):561-72. Epub 2014 May 9 doi: 10.1017/S0950268814001071. PMID: 24814098Free PMC Article
Thromboembolism and congenital malformations: from Duane syndrome to thalidomide embryopathy.
Parsa CF, Robert MP
JAMA Ophthalmol 2013 Apr;131(4):439-47. doi: 10.1001/jamaophthalmol.2013.1111. PMID: 23710497
Posterior leukoencephalopathy syndrome in children and adolescents.
Alehan F, Erol I, Agildere AM, Ozcay F, Baskin E, Cengiz N, Alioglu B, Haberal M
J Child Neurol 2007 Apr;22(4):406-13. doi: 10.1177/0883073807301932. PMID: 17621519
Blindness as a complication of Le Fort I osteotomy for maxillary distraction.
Lo LJ, Hung KF, Chen YR
Plast Reconstr Surg 2002 Feb;109(2):688-98; discussion 699-700. doi: 10.1097/00006534-200202000-00041. PMID: 11818854
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Prognosis

The Abducens Nerve: Anatomy and Pathology.
Lucio LL, Freddi TAL, Ottaiano AC
Semin Ultrasound CT MR 2022 Oct;43(5):414-419. Epub 2022 Apr 18 doi: 10.1053/j.sult.2022.04.008. PMID: 36116854
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
The Medial Pontine Mid-Tegmentum Syndrome.
Wadi LC, Kim MJ, Fisher MJ
J Stroke Cerebrovasc Dis 2020 Jun;29(6):104750. Epub 2020 Mar 24 doi: 10.1016/j.jstrokecerebrovasdis.2020.104750. PMID: 32220556
Magnetic resonance imaging of developmental facial paresis: a spectrum of complex anomalies.
Mohammad SA, Abdelaziz TT, Gadelhak MI, Afifi HH, Abdel-Salam GMH
Neuroradiology 2018 Oct;60(10):1053-1061. Epub 2018 Aug 3 doi: 10.1007/s00234-018-2063-8. PMID: 30074067
Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum.
Manara R, Brotto D, Ghiselli S, Mardari R, Toldo I, Schifano G, Cantone E, Bovo R, Martini A
AJNR Am J Neuroradiol 2015 Jul;36(7):1375-80. Epub 2015 Mar 26 doi: 10.3174/ajnr.A4273. PMID: 25814660Free PMC Article

Clinical prediction guides

Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Syringobulbia in pediatric patients with Chiari malformation type I.
Menezes AH, Greenlee JDW, Dlouhy BJ
J Neurosurg Pediatr 2018 Jul;22(1):52-60. Epub 2018 Apr 27 doi: 10.3171/2018.1.PEDS17472. PMID: 29701558
Orthodontics and Moebius syndrome: an observational study.
Magnifico M, Cassi D, Gandolfini M, Toffoli A, Zecca PA, Di Blasio A
Minerva Stomatol 2018 Aug;67(4):165-171. Epub 2018 Mar 8 doi: 10.23736/S0026-4970.18.04095-5. PMID: 29527867
Clinical correlation of imaging findings in congenital cranial dysinnervation disorders involving abducens nerve.
Gupta C, Sharma P, Saxena R, Garg A, Sharma S
Indian J Ophthalmol 2017 Feb;65(2):155-159. doi: 10.4103/ijo.IJO_1013_15. PMID: 28345573Free PMC Article
Nuclear and infranuclear disorders.
Meienberg O, Müri R
Baillieres Clin Neurol 1992 Aug;1(2):417-34. PMID: 1344077

Recent systematic reviews

Experience in treating children with ocular dyskinesia and hemifacial spasm secondary to pontine tumours adjacent to the fourth ventricle and systematic review.
Cai Y, Yang W, Peng X, Yuan L, Ge M
Childs Nerv Syst 2024 May;40(5):1349-1360. Epub 2024 Jan 16 doi: 10.1007/s00381-024-06280-4. PMID: 38227027
Cranial nerve injuries in Le Fort I osteotomy: a systematic review.
Dos Santos Alves JM, de Freitas Alves BW, de Figueiredo Costa AC, Carneiro BGDS, de Sousa LM, Gondim DV
Int J Oral Maxillofac Surg 2019 May;48(5):601-611. Epub 2018 Dec 28 doi: 10.1016/j.ijom.2018.11.012. PMID: 30598335

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