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Long palm

MedGen UID:
869005
Concept ID:
C4023422
Finding
HPO: HP:0011302

Definition

For children from birth to 16 years of age the length of the palm is more than the 97th centile; or, the length of the palm appears relatively long compared to the finger length or the limb length. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLong palm

Conditions with this feature

Syndromic X-linked intellectual disability Snyder type
MedGen UID:
162918
Concept ID:
C0796160
Disease or Syndrome
Snyder-Robinson syndrome (SRS) is an X-linked intellectual disability syndrome characterized by asthenic build, facial dysmorphism with a prominent lower lip, kyphoscoliosis, osteoporosis, speech abnormalities, and seizures. Developmental delay usually presents as failure to meet early developmental milestones and then evolves to moderate to profound intellectual disability (which appears to remain stable over time) and variable motor disability. Asthenic habitus and low muscle mass usually develop during the first year, even in males who are ambulatory. During the first decade, males with SRS develop osteoporosis, resulting in fractures in the absence of trauma.
Oculocerebrofacial syndrome, Kaufman type
MedGen UID:
343403
Concept ID:
C1855663
Disease or Syndrome
Kaufman oculocerebrofacial syndrome (KOS) is characterized by developmental delay, severe intellectual disability, and distinctive craniofacial features. Most affected children have prenatal-onset microcephaly, hypotonia, and growth deficiency. Feeding issues, ocular abnormalities, hearing impairment, and respiratory tract abnormalities are common. Ocular abnormalities can include structural abnormalities (microcornea or microphthalmia, coloboma, optic nerve hypoplasia), refractive errors (myopia ± astigmatism, hyperopia), strabismus, and entropion. Both conductive and sensorineural hearing loss have been reported as well as mixed conductive-sensorineural hearing loss of variable severity. Breathing problems can lead to prolonged hospitalization after birth in more than half of individuals. Less common findings include ectodermal abnormalities, cardiac manifestations, urogenital abnormalities, seizures, and skeletal abnormalities.
Syndromic X-linked intellectual disability 14
MedGen UID:
372646
Concept ID:
C1970822
Disease or Syndrome
Any X-linked syndromic intellectual disability in which the cause of the disease is a mutation in the UPF3B gene.

Professional guidelines

PubMed

Ayatollahi A, Aramipour N, Sadri A, Firooz A, Robati RM, Fattahi M, Ayazi M, Saber M
Dermatol Ther 2022 Dec;35(12):e15968. Epub 2022 Nov 16 doi: 10.1111/dth.15968. PMID: 36346021
Saguil A, Fargo M, Grogan S
Am Fam Physician 2015 Mar 15;91(6):365-71. PMID: 25822554
Obstet Gynecol 2013 Apr;121(4):891-896. doi: 10.1097/01.AOG.0000428646.67925.9a. PMID: 23635706

Recent clinical studies

Etiology

Ramgopal MN, Castagna A, Cazanave C, Diaz-Brito V, Dretler R, Oka S, Osiyemi O, Walmsley S, Sims J, Di Perri G, Sutton K, Sutherland-Phillips D, Berni A, Latham CL, Zhang F, D'Amico R, Pascual Bernáldez M, Van Solingen-Ristea R, Van Eygen V, Patel P, Chounta V, Spreen WR, Garges HP, Smith K, van Wyk J
Lancet HIV 2023 Sep;10(9):e566-e577. Epub 2023 Aug 8 doi: 10.1016/S2352-3018(23)00136-4. PMID: 37567205
Llibre JM, Brites C, Cheng CY, Osiyemi O, Galera C, Hocqueloux L, Maggiolo F, Degen O, Taylor S, Blair E, Man C, Wynne B, Oyee J, Underwood M, Curtis L, Bontempo G, van Wyk J
Clin Infect Dis 2023 Feb 18;76(4):720-729. doi: 10.1093/cid/ciac130. PMID: 35235656Free PMC Article
Krittanawong C, Isath A, Rosenson RS, Khawaja M, Wang Z, Fogg SE, Virani SS, Qi L, Cao Y, Long MT, Tangney CC, Lavie CJ
Am J Med 2022 Oct;135(10):1213-1230.e3. Epub 2022 May 14 doi: 10.1016/j.amjmed.2022.04.021. PMID: 35580715Free PMC Article
Toma C, Bunte MC, Cho KH, Jaber WA, Chambers J, Stegman B, Gondi S, Leung DA, Savin M, Khandhar S, Kado H, Koenig G, Weinberg M, Beasley RE, Roberts J, Angel W, Sarosi MG, Qaqi O, Veerina K, Brown MA, Pollak JS
Catheter Cardiovasc Interv 2022 Mar;99(4):1345-1355. Epub 2022 Feb 3 doi: 10.1002/ccd.30091. PMID: 35114059Free PMC Article
Wouk N, Helton M
Am Fam Physician 2019 Apr 1;99(7):435-443. PMID: 30932448

Diagnosis

Islam YFK, Khurshid SG
Curr Opin Ophthalmol 2022 Nov 1;33(6):525-531. Epub 2022 Jul 12 doi: 10.1097/ICU.0000000000000863. PMID: 35819905
COVIDSurg Collaborative, GlobalSurg Collaborative
Br J Surg 2021 Sep 27;108(9):1056-1063. doi: 10.1093/bjs/znab101. PMID: 33761533Free PMC Article
COVIDSurg Collaborative; GlobalSurg Collaborative
Anaesthesia 2021 Jun;76(6):748-758. Epub 2021 Mar 9 doi: 10.1111/anae.15458. PMID: 33690889Free PMC Article
Wouk N, Helton M
Am Fam Physician 2019 Apr 1;99(7):435-443. PMID: 30932448
Saguil A, Fargo M, Grogan S
Am Fam Physician 2015 Mar 15;91(6):365-71. PMID: 25822554

Therapy

Ramgopal MN, Castagna A, Cazanave C, Diaz-Brito V, Dretler R, Oka S, Osiyemi O, Walmsley S, Sims J, Di Perri G, Sutton K, Sutherland-Phillips D, Berni A, Latham CL, Zhang F, D'Amico R, Pascual Bernáldez M, Van Solingen-Ristea R, Van Eygen V, Patel P, Chounta V, Spreen WR, Garges HP, Smith K, van Wyk J
Lancet HIV 2023 Sep;10(9):e566-e577. Epub 2023 Aug 8 doi: 10.1016/S2352-3018(23)00136-4. PMID: 37567205
Llibre JM, Brites C, Cheng CY, Osiyemi O, Galera C, Hocqueloux L, Maggiolo F, Degen O, Taylor S, Blair E, Man C, Wynne B, Oyee J, Underwood M, Curtis L, Bontempo G, van Wyk J
Clin Infect Dis 2023 Feb 18;76(4):720-729. doi: 10.1093/cid/ciac130. PMID: 35235656Free PMC Article
Krittanawong C, Isath A, Rosenson RS, Khawaja M, Wang Z, Fogg SE, Virani SS, Qi L, Cao Y, Long MT, Tangney CC, Lavie CJ
Am J Med 2022 Oct;135(10):1213-1230.e3. Epub 2022 May 14 doi: 10.1016/j.amjmed.2022.04.021. PMID: 35580715Free PMC Article
Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA
Nature 2021 Nov;599(7885):485-490. Epub 2021 Nov 10 doi: 10.1038/s41586-021-04075-0. PMID: 34759321
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators
N Engl J Med 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. PMID: 24450891Free PMC Article

Prognosis

Mütze U, Ottenberger A, Gleich F, Maier EM, Lindner M, Husain RA, Palm K, Beblo S, Freisinger P, Santer R, Thimm E, Vom Dahl S, Weinhold N, Grohmann-Held K, Haase C, Hennermann JB, Hörbe-Blindt A, Kamrath C, Marquardt I, Marquardt T, Behne R, Haas D, Spiekerkoetter U, Hoffmann GF, Garbade SF, Grünert SC, Kölker S
Ann Clin Transl Neurol 2024 Apr;11(4):883-898. Epub 2024 Jan 23 doi: 10.1002/acn3.52002. PMID: 38263760Free PMC Article
Reissner L, Schweizer A, Unterfrauner I, Estermann L, Nagy L
J Hand Surg Eur Vol 2021 Jul;46(6):626-631. Epub 2021 Apr 12 doi: 10.1177/17531934211004459. PMID: 33844599Free PMC Article
Rauen T, Wied S, Fitzner C, Eitner F, Sommerer C, Zeier M, Otte B, Panzer U, Budde K, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JFE, Hilgers RD, Floege J; STOP-IgAN Investigators
Kidney Int 2020 Oct;98(4):1044-1052. Epub 2020 May 22 doi: 10.1016/j.kint.2020.04.046. PMID: 32450154
Pravda J
Discov Med 2019 May;27(149):197-200. PMID: 31361982
Kordyukova LV, Serebryakova MV, Khrustalev VV, Veit M
Protein Pept Lett 2019;26(8):588-600. doi: 10.2174/0929866526666190603082521. PMID: 31161979

Clinical prediction guides

Llibre JM, Brites C, Cheng CY, Osiyemi O, Galera C, Hocqueloux L, Maggiolo F, Degen O, Taylor S, Blair E, Man C, Wynne B, Oyee J, Underwood M, Curtis L, Bontempo G, van Wyk J
Clin Infect Dis 2023 Feb 18;76(4):720-729. doi: 10.1093/cid/ciac130. PMID: 35235656Free PMC Article
Krittanawong C, Isath A, Rosenson RS, Khawaja M, Wang Z, Fogg SE, Virani SS, Qi L, Cao Y, Long MT, Tangney CC, Lavie CJ
Am J Med 2022 Oct;135(10):1213-1230.e3. Epub 2022 May 14 doi: 10.1016/j.amjmed.2022.04.021. PMID: 35580715Free PMC Article
Kordyukova LV, Serebryakova MV, Khrustalev VV, Veit M
Protein Pept Lett 2019;26(8):588-600. doi: 10.2174/0929866526666190603082521. PMID: 31161979
Wallace TC
J Am Coll Nutr 2019 Feb;38(2):97-107. Epub 2018 Nov 5 doi: 10.1080/07315724.2018.1497562. PMID: 30395784
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators
N Engl J Med 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. PMID: 24450891Free PMC Article

Recent systematic reviews

Franco JV, Trivisonno L, Sgarbossa NJ, Alvez GA, Fieiras C, Escobar Liquitay CM, Jung JH
Cochrane Database Syst Rev 2023 Jun 22;6(6):CD001423. doi: 10.1002/14651858.CD001423.pub4. PMID: 37345871Free PMC Article
Manzi J, Kew M, Zeitlin J, Sudah SY, Sandoval T, Kunze KN, Haeberle H, Ciccotti MC, Carr JB 2nd, Dines JS
Arthroscopy 2023 May;39(5):1330-1344. Epub 2023 Jan 14 doi: 10.1016/j.arthro.2023.01.004. PMID: 36649827
Schmüdderich K, Kiwitt J, Palm R, Roes M, Holle B
J Clin Nurs 2023 May;32(9-10):1858-1884. Epub 2022 Feb 4 doi: 10.1111/jocn.16231. PMID: 35122351
Krittanawong C, Isath A, Rosenson RS, Khawaja M, Wang Z, Fogg SE, Virani SS, Qi L, Cao Y, Long MT, Tangney CC, Lavie CJ
Am J Med 2022 Oct;135(10):1213-1230.e3. Epub 2022 May 14 doi: 10.1016/j.amjmed.2022.04.021. PMID: 35580715Free PMC Article
Tacklind J, Macdonald R, Rutks I, Stanke JU, Wilt TJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD001423. doi: 10.1002/14651858.CD001423.pub3. PMID: 23235581Free PMC Article

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