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Abnormal shape of the frontal region

MedGen UID:
869040
•Concept ID:
C4023458
•
Anatomical Abnormality
Synonyms: Abnormal morphology of the frontal region; Abnormal shape of the forehead; Dysmorphic forehead; Dysmorphic frontal region
 
HPO: HP:0011218

Definition

An abnormal shape of the frontal part of the head. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal shape of the frontal region

Professional guidelines

PubMed

Interfrontal encephalocele: a rare feature of forehead in hydrocephalic myelomeningocele patients. Clinical feature, probable mechanisms, and management.
Nejat F, Kamali S, El Khashab M
Childs Nerv Syst 2013 Aug;29(8):1349-52. Epub 2013 Feb 22 doi: 10.1007/s00381-013-2050-7. PMID: 23864232
Catechol-O-methyltransferase genotype modifies executive functioning and prefrontal functional connectivity in women with anorexia nervosa.
Favaro A, Clementi M, Manara R, Bosello R, Forzan M, Bruson A, Tenconi E, Degortes D, Titton F, Di Salle F, Santonastaso P
J Psychiatry Neurosci 2013 Jul;38(4):241-8. doi: 10.1503/jpn.120068. PMID: 23046831Free PMC Article
Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia.
Reddick WE, Glass JO, Johnson DP, Laningham FH, Pui CH
AJNR Am J Neuroradiol 2009 Nov;30(10):1947-54. Epub 2009 Jul 30 doi: 10.3174/ajnr.A1733. PMID: 19643920Free PMC Article

Recent clinical studies

Etiology

Cortical and subcortical morphological alterations in postpartum depression.
Yang W, Jiang Y, Ma L, Xiao M, Liu M, Ren Z, Zhang Y, Hu L
Behav Brain Res 2023 Jun 5;447:114414. Epub 2023 Mar 29 doi: 10.1016/j.bbr.2023.114414. PMID: 37001820
An automatic facial landmarking for children with rare diseases.
Hennocq Q, Bongibault T, Bizière M, Delassus O, Douillet M, Cormier-Daire V, Amiel J, Lyonnet S, Marlin S, Rio M, Picard A, Khonsari RH, Garcelon N
Am J Med Genet A 2023 May;191(5):1210-1221. Epub 2023 Jan 30 doi: 10.1002/ajmg.a.63126. PMID: 36714960
Radiomic features of gray matter in never-treated first-episode schizophrenia.
Zhu F, Xiao Y, Tao B, Gao Z, Gao X, Zhao Q, Zhang Q, Tang B, Zhang X, Zhao Y, Bishop JR, Sweeney JA, Lui S
Cereb Cortex 2023 May 9;33(10):5957-5967. doi: 10.1093/cercor/bhac474. PMID: 36513368
Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.
Nakamura M, Takahashi T, Takayanagi Y, Sasabayashi D, Katagiri N, Sakuma A, Obara C, Koike S, Yamasue H, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Kasai K, Suzuki M
Eur Arch Psychiatry Clin Neurosci 2019 Jun;269(4):397-406. Epub 2018 Mar 23 doi: 10.1007/s00406-018-0890-6. PMID: 29572660
Alcohol consumption and abnormalities of brain structure and vasculature.
Mukamal KJ
Am J Geriatr Cardiol 2004 Jan-Feb;13(1):22-8. doi: 10.1111/j.1076-7460.2004.01334.x. PMID: 14724398

Diagnosis

Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature.
van Amerongen S, Kamps S, Kaijser KKM, Pijnenburg YAL, Scheltens P, Teunissen CE, Barkhof F, Ossenkoppele R, Rozemuller AJM, Stern RA, Hoozemans JJM, Vijverberg EGB
Acta Neuropathol Commun 2023 May 10;11(1):77. doi: 10.1186/s40478-023-01572-3. PMID: 37161501Free PMC Article
Structure of pathological TDP-43 filaments from ALS with FTLD.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B
Nature 2022 Jan;601(7891):139-143. Epub 2021 Dec 8 doi: 10.1038/s41586-021-04199-3. PMID: 34880495Free PMC Article
Neuroimaging in Attention-Deficit/Hyperactivity Disorder: Recent Advances.
Firouzabadi FD, Ramezanpour S, Firouzabadi MD, Yousem IJ, Puts NAJ, Yousem DM
AJR Am J Roentgenol 2022 Feb;218(2):321-332. Epub 2021 Aug 18 doi: 10.2214/AJR.21.26316. PMID: 34406053
Moral conduct and social behavior.
de Oliveira-Souza R, Moll J
Handb Clin Neurol 2019;163:295-315. doi: 10.1016/B978-0-12-804281-6.00016-1. PMID: 31590736
Alcohol consumption and abnormalities of brain structure and vasculature.
Mukamal KJ
Am J Geriatr Cardiol 2004 Jan-Feb;13(1):22-8. doi: 10.1111/j.1076-7460.2004.01334.x. PMID: 14724398

Therapy

Lateral Ventricle Enlargement and Cortical Thinning in Idiopathic Normal-pressure Hydrocephalus Patients.
Kang K, Kwak K, Yoon U, Lee JM
Sci Rep 2018 Sep 6;8(1):13306. doi: 10.1038/s41598-018-31399-1. PMID: 30190599Free PMC Article
What Do We Know About the Influence of the Cerebellum on Walking Ability? Promising Findings from Transcranial Alternating Current Stimulation.
Naro A, Milardi D, Cacciola A, Russo M, Sciarrone F, La Rosa G, Bramanti A, Bramanti P, Calabrò RS
Cerebellum 2017 Aug;16(4):859-867. doi: 10.1007/s12311-017-0859-4. PMID: 28456901
Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: attenuated by medication.
Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Perlman SB, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Arnold LE, Fristad MA, Frazier TW, Youngstrom EA, Findling RL, Drevets W, Phillips ML
J Psychiatr Res 2014 Nov;58:129-36. Epub 2014 Aug 8 doi: 10.1016/j.jpsychires.2014.07.023. PMID: 25151338Free PMC Article
Functional neuroanatomy of body shape perception in healthy and eating-disordered women.
Uher R, Murphy T, Friederich HC, Dalgleish T, Brammer MJ, Giampietro V, Phillips ML, Andrew CM, Ng VW, Williams SC, Campbell IC, Treasure J
Biol Psychiatry 2005 Dec 15;58(12):990-7. Epub 2005 Aug 8 doi: 10.1016/j.biopsych.2005.06.001. PMID: 16084858
Alcohol consumption and abnormalities of brain structure and vasculature.
Mukamal KJ
Am J Geriatr Cardiol 2004 Jan-Feb;13(1):22-8. doi: 10.1111/j.1076-7460.2004.01334.x. PMID: 14724398

Prognosis

Radiomic features of gray matter in never-treated first-episode schizophrenia.
Zhu F, Xiao Y, Tao B, Gao Z, Gao X, Zhao Q, Zhang Q, Tang B, Zhang X, Zhao Y, Bishop JR, Sweeney JA, Lui S
Cereb Cortex 2023 May 9;33(10):5957-5967. doi: 10.1093/cercor/bhac474. PMID: 36513368
Aberrant orbitofrontal cortex reactivity to erotic cues in Compulsive Sexual Behavior Disorder.
Golec K, Draps M, Stark R, Pluta A, Gola M
J Behav Addict 2021 Aug 25;10(3):646-656. doi: 10.1556/2006.2021.00051. PMID: 34437297Free PMC Article
The posture of adolescent male handball players: A two-year study.
Grabara M
J Back Musculoskelet Rehabil 2018 Feb 6;31(1):183-189. doi: 10.3233/BMR-170792. PMID: 28946537
Post-Surgical Relapse in Metopic Synostosis and Limitations of the Interfrontal Angle as an Outcome Measure.
Glener AD, Allori AC, Shammas RL, Farjat AE, Marcus JR
J Craniofac Surg 2017 Jul;28(5):e494-e500. doi: 10.1097/SCS.0000000000003800. PMID: 28665858
Characteristic features and progression of abnormalities on MRI for CARASIL.
Nozaki H, Sekine Y, Fukutake T, Nishimoto Y, Shimoe Y, Shirata A, Yanagawa S, Hirayama M, Tamura M, Nishizawa M, Onodera O
Neurology 2015 Aug 4;85(5):459-63. Epub 2015 Jul 2 doi: 10.1212/WNL.0000000000001803. PMID: 26138950

Clinical prediction guides

Cortical and subcortical morphological alterations in postpartum depression.
Yang W, Jiang Y, Ma L, Xiao M, Liu M, Ren Z, Zhang Y, Hu L
Behav Brain Res 2023 Jun 5;447:114414. Epub 2023 Mar 29 doi: 10.1016/j.bbr.2023.114414. PMID: 37001820
Radiomic features of gray matter in never-treated first-episode schizophrenia.
Zhu F, Xiao Y, Tao B, Gao Z, Gao X, Zhao Q, Zhang Q, Tang B, Zhang X, Zhao Y, Bishop JR, Sweeney JA, Lui S
Cereb Cortex 2023 May 9;33(10):5957-5967. doi: 10.1093/cercor/bhac474. PMID: 36513368
All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders.
Northoff G, Hirjak D, Wolf RC, Magioncalda P, Martino M
Mol Psychiatry 2021 Jan;26(1):92-102. Epub 2020 Jun 17 doi: 10.1038/s41380-020-0814-5. PMID: 32555423
Moral conduct and social behavior.
de Oliveira-Souza R, Moll J
Handb Clin Neurol 2019;163:295-315. doi: 10.1016/B978-0-12-804281-6.00016-1. PMID: 31590736
Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder.
Sun ZY, Houenou J, Duclap D, Sarrazin S, Linke J, Daban C, Hamdani N, d'Albis MA, Le Corvoisier P, Guevara P, Delavest M, Bellivier F, Bellivier F, Almeida J, Versace A, Poupon C, Leboyer M, Phillips M, Wessa M, Mangin JF
J Psychiatry Neurosci 2017 Jan;42(1):27-36. doi: 10.1503/jpn.150291. PMID: 28234596Free PMC Article

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