U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal epidermal morphology

MedGen UID:
869108
•Concept ID:
C4023526
•
Anatomical Abnormality
Synonym: Abnormality of epidermal morphology
 
HPO: HP:0011124

Definition

An abnormality of the morphology of the epidermis. [from HPO]

Professional guidelines

PubMed

Treatment sequencing in metastatic colorectal cancer.
Modest DP, Pant S, Sartore-Bianchi A
Eur J Cancer 2019 Mar;109:70-83. Epub 2019 Jan 25 doi: 10.1016/j.ejca.2018.12.019. PMID: 30690295
Small fiber neuropathy: Diagnosis, causes, and treatment.
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders.
Lodén M
Am J Clin Dermatol 2003;4(11):771-88. doi: 10.2165/00128071-200304110-00005. PMID: 14572299

Recent clinical studies

Etiology

Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Epidermolysis Bullosa: Pediatric Perspectives.
Hon KL, Chu S, Leung AKC
Curr Pediatr Rev 2022;18(3):182-190. doi: 10.2174/1573396317666210525161252. PMID: 34036913
Psoriatic alopecia.
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Normal and abnormal skin color.
Ortonne JP
Ann Dermatol Venereol 2012 Dec;139 Suppl 4:S125-9. doi: 10.1016/S0151-9638(12)70123-0. PMID: 23522626
Ceramides and skin function.
Coderch L, López O, de la Maza A, Parra JL
Am J Clin Dermatol 2003;4(2):107-29. doi: 10.2165/00128071-200304020-00004. PMID: 12553851

Diagnosis

Intrapatient comparison of atopic dermatitis skin transcriptome shows differences between tape-strips and biopsies.
Del Duca E, He H, Liu Y, Pagan AD, David E, Cheng J, Carroll B, Renert-Yuval Y, Bar J, Estrada YD, Maari C, Proulx ES, Krueger JG, Bissonnette R, Guttman-Yassky E
Allergy 2024 Jan;79(1):80-92. Epub 2023 Aug 14 doi: 10.1111/all.15845. PMID: 37577841
Epidermolysis Bullosa: Pediatric Perspectives.
Hon KL, Chu S, Leung AKC
Curr Pediatr Rev 2022;18(3):182-190. doi: 10.2174/1573396317666210525161252. PMID: 34036913
Ethnic hair disorders.
Lindsey SF, Tosti A
Curr Probl Dermatol 2015;47:139-49. Epub 2015 Feb 20 doi: 10.1159/000369414. PMID: 26370652
Epidermal nevus syndromes.
Sugarman JL
Semin Cutan Med Surg 2007 Dec;26(4):221-30. doi: 10.1016/j.sder.2008.03.006. PMID: 18395670
Epidermal nevus syndromes.
Sugarman JL
Semin Cutan Med Surg 2004 Jun;23(2):145-57. doi: 10.1016/j.sder.2004.01.008. PMID: 15295924

Therapy

Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD
J Allergy Clin Immunol 2019 Jan;143(1):155-172. Epub 2018 Sep 5 doi: 10.1016/j.jaci.2018.08.022. PMID: 30194992
Small fiber neuropathy: Diagnosis, causes, and treatment.
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Heterogeneous Pathology of Melasma and Its Clinical Implications.
Kwon SH, Hwang YJ, Lee SK, Park KC
Int J Mol Sci 2016 May 26;17(6) doi: 10.3390/ijms17060824. PMID: 27240341Free PMC Article
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563
Ceramides and skin function.
Coderch L, López O, de la Maza A, Parra JL
Am J Clin Dermatol 2003;4(2):107-29. doi: 10.2165/00128071-200304020-00004. PMID: 12553851

Prognosis

Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review.
Upadhyay PR, Seminario-Vidal L, Abe B, Ghobadi C, Sims JT
Cells 2023 Dec 8;12(24) doi: 10.3390/cells12242793. PMID: 38132113Free PMC Article
Epidermolysis Bullosa: Pediatric Perspectives.
Hon KL, Chu S, Leung AKC
Curr Pediatr Rev 2022;18(3):182-190. doi: 10.2174/1573396317666210525161252. PMID: 34036913
Orthopedic issues in vascular anomalies.
Spencer SA, Sorger JI
Semin Pediatr Surg 2020 Oct;29(5):150973. Epub 2020 Sep 19 doi: 10.1016/j.sempedsurg.2020.150973. PMID: 33069292
Small fiber neuropathy: Diagnosis, causes, and treatment.
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563

Clinical prediction guides

Epidermolysis Bullosa: Pediatric Perspectives.
Hon KL, Chu S, Leung AKC
Curr Pediatr Rev 2022;18(3):182-190. doi: 10.2174/1573396317666210525161252. PMID: 34036913
Aquaporin-3 in the epidermis: more than skin deep.
Bollag WB, Aitkens L, White J, Hyndman KA
Am J Physiol Cell Physiol 2020 Jun 1;318(6):C1144-C1153. Epub 2020 Apr 8 doi: 10.1152/ajpcell.00075.2020. PMID: 32267715Free PMC Article
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
Thatikonda S, Pooladanda V, Sigalapalli DK, Godugu C
Cell Death Dis 2020 Jan 10;11(1):21. doi: 10.1038/s41419-019-2212-y. PMID: 31924750Free PMC Article
Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders.
Lodén M
Am J Clin Dermatol 2003;4(11):771-88. doi: 10.2165/00128071-200304110-00005. PMID: 14572299
Vitiligo.
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760

Recent systematic reviews

Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review.
Upadhyay PR, Seminario-Vidal L, Abe B, Ghobadi C, Sims JT
Cells 2023 Dec 8;12(24) doi: 10.3390/cells12242793. PMID: 38132113Free PMC Article
Ocular manifestations of vitiligo: a systematic review.
LeWitt T, Tauscher R, Obiofuma G, Peterson J, Haddadin R, Kundu RV
BMC Ophthalmol 2023 Mar 27;23(1):120. doi: 10.1186/s12886-023-02777-9. PMID: 36973683Free PMC Article
Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data.
Szturz P, Budíková M, Vermorken JB, Horová I, Gál B, Raymond E, de Gramont A, Faivre S
Oral Oncol 2017 Nov;74:68-76. Epub 2017 Sep 27 doi: 10.1016/j.oraloncology.2017.09.009. PMID: 29103754
Eruptive vellus hair cysts: a systematic review.
Torchia D, Vega J, Schachner LA
Am J Clin Dermatol 2012 Feb 1;13(1):19-28. doi: 10.2165/11589050-000000000-00000. PMID: 21958358
Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): a systematic review and economic analysis.
Fleeman N, Bagust A, Boland A, Dickson R, Dundar Y, Moonan M, Oyee J, Blundell M, Davis H, Armstrong A, Thorp N
Health Technol Assess 2011;15(42):1-93, iii-iv. doi: 10.3310/hta15420. PMID: 22152751Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...