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Postnatal cystic hygroma

MedGen UID:
869254
•Concept ID:
C4023677
•
Anatomical Abnormality
HPO: HP:0010879

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostnatal cystic hygroma

Professional guidelines

PubMed

Analysis of cystic hygroma diagnosed in the prenatal period: 5-years' experience at a tertiary hospital in Southeastern Turkey.
Özcan HÇ, Uğur MG, Balat Ö, Sucu S, Bayramoğlu Tepe N, Öztürk E, Kömürcü Karuserci Ö, Kazaz TG
J Matern Fetal Neonatal Med 2019 Jun;32(11):1800-1805. Epub 2017 Dec 27 doi: 10.1080/14767058.2017.1418315. PMID: 29241391
Postnatal management of prenatally diagnosed abdominal masses and anomalies.
Heaton TE, Liechty KW
Prenat Diagn 2008 Jul;28(7):656-66. doi: 10.1002/pd.1933. PMID: 18324619
Early prenatal diagnosis of axillary cystic hygroma.
Reichler A, Bronshtein M
J Ultrasound Med 1995 Aug;14(8):581-4. doi: 10.7863/jum.1995.14.8.581. PMID: 7474055

Recent clinical studies

Etiology

Prenatal phenotype of Wolf-Hirschhorn syndrome: A case series and literature review.
Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Euploid First-Trimester Cystic Hygroma: A More Benign Entity than Previously Thought?
Malone CM, Mullers S, Kelliher N, Dalrymple J, O'Beirnes J, Flood K, Malone F
Fetal Diagn Ther 2021;48(9):667-671. Epub 2021 Sep 21 doi: 10.1159/000519056. PMID: 34569548
Outcome of antenatally diagnosed cystic hygroma - Lessons learnt.
Behera S, Bawa M, Kanojia RP, Saha PK, Singh T, Samujh R
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110227. Epub 2020 Jul 11 doi: 10.1016/j.ijporl.2020.110227. PMID: 33137866
Multidisciplinary approach in cystic hygroma: prenatal diagnosis, outcome, and postnatal follow up.
Gedikbasi A, Oztarhan K, Aslan G, Demirali O, Akyol A, Sargin A, Ceylan Y
Pediatr Int 2009 Oct;51(5):670-7. Epub 2009 Mar 13 doi: 10.1111/j.1442-200X.2009.02846.x. PMID: 19419502
Prenatally diagnosed cystic lymphangioma in infants.
Suzuki N, Tsuchida Y, Takahashi A, Kuroiwa M, Ikeda H, Mohara J, Hatakeyama S, Koizumi T
J Pediatr Surg 1998 Nov;33(11):1599-604. doi: 10.1016/s0022-3468(98)90589-9. PMID: 9856875

Diagnosis

Prenatal phenotype of Wolf-Hirschhorn syndrome: A case series and literature review.
Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Euploid First-Trimester Cystic Hygroma: A More Benign Entity than Previously Thought?
Malone CM, Mullers S, Kelliher N, Dalrymple J, O'Beirnes J, Flood K, Malone F
Fetal Diagn Ther 2021;48(9):667-671. Epub 2021 Sep 21 doi: 10.1159/000519056. PMID: 34569548
Comparative assessment of gene-specific variant distribution in prenatal and postnatal cohorts tested for Noonan syndrome and related conditions.
Leach NT, Wilson Mathews DR, Rosenblum LS, Zhou Z, Zhu H, Heim RA
Genet Med 2019 Feb;21(2):417-425. Epub 2018 Jun 15 doi: 10.1038/s41436-018-0062-0. PMID: 29907801
Fetal mediastinal lymphangiomas.
Comstock CH, Lee W, Bronsteen RA, Vettraino I, Wechter D
J Ultrasound Med 2008 Jan;27(1):145-8. doi: 10.7863/jum.2008.27.1.145. PMID: 18096741
Lymphangioma circumscriptum.
Mordehai J, Kurzbart E, Shinhar D, Sagi A, Finaly R, Mares AJ
Pediatr Surg Int 1998 Mar;13(2-3):208-10. doi: 10.1007/s003830050295. PMID: 9563054

Therapy

Synchronous ipsilateral Bochdalek and Morgagni diaphragmatic hernias: a case report.
Jelin EB, Kim TN, Nathan N, Miniati D
J Pediatr Surg 2011 Dec;46(12):2383-6. doi: 10.1016/j.jpedsurg.2011.09.062. PMID: 22152887
Role of prenatal ultrasonography in women with positive screen for Down syndrome on the basis of maternal serum markers.
Nyberg DA, Luthy DA, Cheng EY, Sheley RC, Resta RG, Williams MA
Am J Obstet Gynecol 1995 Oct;173(4):1030-5. doi: 10.1016/0002-9378(95)91322-x. PMID: 7485289

Prognosis

Prenatal phenotype of Wolf-Hirschhorn syndrome: A case series and literature review.
Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Outcome of 45,X fetuses with cystic hygroma: A systematic review.
Levy AT, Berghella V, Al-Kouatly HB
Am J Med Genet A 2021 Jan;185(1):26-32. Epub 2020 Oct 7 doi: 10.1002/ajmg.a.61902. PMID: 33026168
Outcome of antenatally diagnosed cystic hygroma - Lessons learnt.
Behera S, Bawa M, Kanojia RP, Saha PK, Singh T, Samujh R
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110227. Epub 2020 Jul 11 doi: 10.1016/j.ijporl.2020.110227. PMID: 33137866
Multidisciplinary approach in cystic hygroma: prenatal diagnosis, outcome, and postnatal follow up.
Gedikbasi A, Oztarhan K, Aslan G, Demirali O, Akyol A, Sargin A, Ceylan Y
Pediatr Int 2009 Oct;51(5):670-7. Epub 2009 Mar 13 doi: 10.1111/j.1442-200X.2009.02846.x. PMID: 19419502
Poor prenatal detection rate of cardiac anomalies in Noonan syndrome.
Menashe M, Arbel R, Raveh D, Achiron R, Yagel S
Ultrasound Obstet Gynecol 2002 Jan;19(1):51-5. doi: 10.1046/j.0960-7692.2001.00485.x. PMID: 11851968

Clinical prediction guides

Prenatal phenotype of Wolf-Hirschhorn syndrome: A case series and literature review.
Tang F, Zeng Y, Wang L, Yin D, Chen L, Xie D, Wang J
Mol Genet Genomic Med 2023 Jun;11(6):e2155. Epub 2023 Feb 27 doi: 10.1002/mgg3.2155. PMID: 36849216Free PMC Article
Biallelic THOC6 pathogenic variants: Prenatal phenotype and review of the literature.
Ruaud L, Roux N, Boutaud L, Bessières B, Ageorges F, Achaiaa A, Bole C, Nitschke P, Masson C, Vekemans M, Verloes A, Attie-Bitach T
Birth Defects Res 2022 Jun;114(10):499-504. Epub 2022 Apr 15 doi: 10.1002/bdr2.2011. PMID: 35426486
Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.
Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Nguyen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M, Sasahara M
Proc Natl Acad Sci U S A 2021 May 11;118(19) doi: 10.1073/pnas.2019580118. PMID: 33941693Free PMC Article
Outcome of antenatally diagnosed cystic hygroma - Lessons learnt.
Behera S, Bawa M, Kanojia RP, Saha PK, Singh T, Samujh R
Int J Pediatr Otorhinolaryngol 2020 Nov;138:110227. Epub 2020 Jul 11 doi: 10.1016/j.ijporl.2020.110227. PMID: 33137866
Comparative assessment of gene-specific variant distribution in prenatal and postnatal cohorts tested for Noonan syndrome and related conditions.
Leach NT, Wilson Mathews DR, Rosenblum LS, Zhou Z, Zhu H, Heim RA
Genet Med 2019 Feb;21(2):417-425. Epub 2018 Jun 15 doi: 10.1038/s41436-018-0062-0. PMID: 29907801

Recent systematic reviews

Outcome of 45,X fetuses with cystic hygroma: A systematic review.
Levy AT, Berghella V, Al-Kouatly HB
Am J Med Genet A 2021 Jan;185(1):26-32. Epub 2020 Oct 7 doi: 10.1002/ajmg.a.61902. PMID: 33026168
Pentasomy 49,XXXXY diagnosed in utero: case report and systematic review of antenatal findings.
Peitsidis P, Manolakos E, Peitsidou A, Petersen MB, Tsoplou P, Kadir R, Agapitos E
Fetal Diagn Ther 2009;26(1):1-5. Epub 2009 Oct 10 doi: 10.1159/000236351. PMID: 19816022

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