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EEG with multifocal slow activity

MedGen UID:
869262
Concept ID:
C4023687
Finding
HPO: HP:0010844

Definition

Multifocal slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG). [from HPO]

Term Hierarchy

Conditions with this feature

Hyperphosphatasia with intellectual disability syndrome 6
MedGen UID:
906509
Concept ID:
C4225201
Disease or Syndrome
Hyperphosphatasia with impaired intellectual development syndrome-6 (HPMRS6) is an autosomal recessive multisystem disorder characterized by global developmental delay, dysmorphic features, seizures, and congenital cataracts. Severity is variable, and the disorder may show a range of phenotypic and biochemical abnormalities, including increased serum alkaline phosphatase levels (summary by Ilkovski et al., 2015). The disorder is caused by a defect in glycosylphosphatidylinositol (GPI) biosynthesis. For a discussion of genetic heterogeneity of HPMRS, see HPMRS1 (239300). For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).

Professional guidelines

PubMed

Montouris G, Aboumatar S, Burdette D, Kothare S, Kuzniecky R, Rosenfeld W, Chung S
Epilepsy Behav 2020 Sep;110:107146. Epub 2020 Jun 18 doi: 10.1016/j.yebeh.2020.107146. PMID: 32563898
Benbadis SR, Chen S, Melo M
Epilepsia 2010 Nov;51(11):2338-40. doi: 10.1111/j.1528-1167.2010.02683.x. PMID: 20738384
Velasco F, Velasco M, Ogarrio C, Fanghanel G
Epilepsia 1987 Jul-Aug;28(4):421-30. doi: 10.1111/j.1528-1157.1987.tb03668.x. PMID: 3497802

Recent clinical studies

Etiology

Oliver KL, Trivisano M, Mandelstam SA, De Dominicis A, Francis DI, Green TE, Muir AM, Chowdhary A, Hertzberg C, Goldhahn K, Metreau J, Prager C, Pinner J, Cardamone M, Myers KA, Leventer RJ, Lesca G, Bahlo M, Hildebrand MS, Mefford HC, Kaindl AM, Specchio N, Scheffer IE
Epilepsia 2023 May;64(5):1351-1367. Epub 2023 Mar 11 doi: 10.1111/epi.17542. PMID: 36779245Free PMC Article
DiFrancesco JC, Isella V, Licciardo D, Crivellaro C, Musarra M, Guerra L, Salvadori N, Chipi E, Calvello C, Costa C, Ferrarese C
Epilepsy Behav 2021 Apr;117:107839. Epub 2021 Feb 18 doi: 10.1016/j.yebeh.2021.107839. PMID: 33611099
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Buoni S, Zannolli R, De Felice C, De Nicola A, Guerri V, Guerra B, Casali S, Pucci B, Corbini L, Mari F, Renieri A, Zappella M, Hayek J
Clin Neurophysiol 2010 May;121(5):652-7. Epub 2010 Feb 12 doi: 10.1016/j.clinph.2010.01.003. PMID: 20153689
Siniatchkin M, van Baalen A, Jacobs J, Moeller F, Moehring J, Boor R, Wolff S, Jansen O, Stephani U
Epilepsia 2007 Dec;48(12):2312-21. Epub 2007 Jul 21 doi: 10.1111/j.1528-1167.2007.01195.x. PMID: 17645543

Diagnosis

Montouris G, Aboumatar S, Burdette D, Kothare S, Kuzniecky R, Rosenfeld W, Chung S
Epilepsy Behav 2020 Sep;110:107146. Epub 2020 Jun 18 doi: 10.1016/j.yebeh.2020.107146. PMID: 32563898
Markand ON
J Clin Neurophysiol 2003 Nov-Dec;20(6):426-41. doi: 10.1097/00004691-200311000-00005. PMID: 14734932
Glaze DG
Ment Retard Dev Disabil Res Rev 2002;8(2):66-71. doi: 10.1002/mrdd.10024. PMID: 12112729
Curatolo P, Seri S, Verdecchia M, Bombardieri R
Brain Dev 2001 Nov;23(7):502-7. doi: 10.1016/s0387-7604(01)00300-x. PMID: 11701245
Dulac O
Brain Dev 2001 Nov;23(7):447-52. doi: 10.1016/s0387-7604(01)00268-6. PMID: 11701238

Therapy

Montouris G, Aboumatar S, Burdette D, Kothare S, Kuzniecky R, Rosenfeld W, Chung S
Epilepsy Behav 2020 Sep;110:107146. Epub 2020 Jun 18 doi: 10.1016/j.yebeh.2020.107146. PMID: 32563898
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Fattal-Valevski A, Bloch-Mimouni A, Kivity S, Heyman E, Brezner A, Strausberg R, Inbar D, Kramer U, Goldberg-Stern H
Neurology 2009 Sep 15;73(11):828-33. Epub 2009 Jul 1 doi: 10.1212/WNL.0b013e3181b121f5. PMID: 19571254
Takahashi Y, Suzuki Y, Kumazaki K, Tanabe Y, Akaboshi S, Miura K, Shimozawa N, Kondo N, Nishiguchi T, Terada K, Orii T
Epilepsia 1997 Feb;38(2):182-8. doi: 10.1111/j.1528-1157.1997.tb01095.x. PMID: 9048670
Rittey CD
Seizure 1994 Dec;3 Suppl A:25-7. PMID: 7894847

Prognosis

DiFrancesco JC, Isella V, Licciardo D, Crivellaro C, Musarra M, Guerra L, Salvadori N, Chipi E, Calvello C, Costa C, Ferrarese C
Epilepsy Behav 2021 Apr;117:107839. Epub 2021 Feb 18 doi: 10.1016/j.yebeh.2021.107839. PMID: 33611099
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Ma X, Zhang Y, Yang Y, Liu X, Yang Z, Bao X, Qin J, Wu X
Brain Dev 2011 Oct;33(9):790-5. Epub 2011 Jul 20 doi: 10.1016/j.braindev.2011.06.001. PMID: 21764232
Curatolo P, Seri S, Verdecchia M, Bombardieri R
Brain Dev 2001 Nov;23(7):502-7. doi: 10.1016/s0387-7604(01)00300-x. PMID: 11701245
Markand ON
Neurology 1977 Aug;27(8):746-57. doi: 10.1212/wnl.27.8.746. PMID: 407485

Clinical prediction guides

DiFrancesco JC, Isella V, Licciardo D, Crivellaro C, Musarra M, Guerra L, Salvadori N, Chipi E, Calvello C, Costa C, Ferrarese C
Epilepsy Behav 2021 Apr;117:107839. Epub 2021 Feb 18 doi: 10.1016/j.yebeh.2021.107839. PMID: 33611099
Li LH, Ma CC, Zhang HF, Lian YJ
Epilepsy Behav 2018 Nov;88:277-282. Epub 2018 Oct 15 doi: 10.1016/j.yebeh.2018.08.019. PMID: 30332659
Aurangzeb S, Symmonds M, Knight RK, Kennett R, Wehner T, Irani SR
Seizure 2017 Aug;50:14-17. Epub 2017 May 30 doi: 10.1016/j.seizure.2017.05.017. PMID: 28586706Free PMC Article
Buoni S, Zannolli R, De Felice C, De Nicola A, Guerri V, Guerra B, Casali S, Pucci B, Corbini L, Mari F, Renieri A, Zappella M, Hayek J
Clin Neurophysiol 2010 May;121(5):652-7. Epub 2010 Feb 12 doi: 10.1016/j.clinph.2010.01.003. PMID: 20153689
Curatolo P, Seri S, Verdecchia M, Bombardieri R
Brain Dev 2001 Nov;23(7):502-7. doi: 10.1016/s0387-7604(01)00300-x. PMID: 11701245

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