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Esophageal disorder

MedGen UID:: 8693
•Concept ID:: C0014852
•: Disease or Syndrome

Synonym:	Esophageal disease
SNOMED CT:	Disorder of esophagus (37657006)

Monarch Initiative:	MONDO:0003749

Definition

A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEsophageal disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of gastrointestinal tract
        Esophageal disorder
        Barrett esophagus
        Refractory Barrett Esophagus
        Dysphagia
        Dyskinesia of esophagus
        Achalasia
        CREST syndrome
        Esophageal spasms
        Gastroesophageal reflux disease
        Plummer-Vinson syndrome
        Esophageal dysphagia
        Impaired oral bolus formation
        Impaired oropharyngeal swallow response
        Neuromuscular dysphagia
        Oral-pharyngeal dysphagia
        Esophageal atresia
        Proximal esophageal atresia
        Esophageal Cyst
        Esophageal diverticulosis
        Esophageal fistula
        Tracheoesophageal fistula
        H-type congenital tracheoesophageal fistula
        Esophageal Precancerous Condition
        Esophageal dysplasia
        Esophageal Glandular Intraepithelial Neoplasia
        Esophageal High Grade Intraepithelial Neoplasia
        Esophageal Squamous Intraepithelial Neoplasia
        Mild esophageal dysplasia
        Esophageal stenosis
        Esophageal stricture
        Esophageal anastomotic stricture
        Radiation-induced stricture of esophagus
        Esophagitis
        Acute esophagitis
        Bacterial esophagitis
        Chronic esophagitis
        Eosinophilic esophagitis
        Esophagitis, eosinophilic, 1
        Esophagitis, eosinophilic, 2
        Eosinophilic infiltration of the esophagus
        Eosinophilic microabscess formation in the esophagus
        Esophagitides, Peptic
        Fungal esophagitis
        Esophageal candidiasis
        Viral esophagitis
        Esophagitis caused by Cytomegalovirus
        Herpes Esophagitis
        Neoplasm of esophagus
        Benign neoplasm of esophagus
        Esophageal Fibroma
        Esophageal hemangioma
        Esophageal lipoma
        Esophageal Polyp
        Esophageal Schwannoma
        Esophagus leiomyoma
        Neurofibroma of the esophagus
        Esophageal carcinoma
        Adenocarcinoma of esophagus
        Carcinoma of esophagus, salivary gland type
        Childhood Esophageal Carcinoma
        Esophageal adenoid cystic carcinoma
        Esophageal adenosquamous carcinoma
        Esophageal Cancer by AJCC v6 Stage
        Esophageal Cancer by AJCC v7 Stage
        Esophageal Cancer by AJCC v8 Stage
        Esophageal Mixed Adenoneuroendocrine Carcinoma
        Esophageal Neuroendocrine Carcinoma
        Esophageal squamous cell carcinoma
        Localized Esophageal Carcinoma
        Metastatic Esophageal Carcinoma
        Mucoepidermoid esophageal carcinoma
        Recurrent Esophageal Carcinoma
        Refractory Esophageal Carcinoma
        Undifferentiated carcinoma of esophagus
        Unresectable Esophageal Carcinoma
        Esophageal granular cell tumor
        Esophageal Neuroendocrine Neoplasm
        Esophageal neuroendocrine tumor
        Esophageal Soft Tissue Neoplasm
        Esophageal Gastrointestinal Stromal Tumor
        Esophagus sarcoma
        Esophageal squamous papilloma
        Malignant tumor of esophagus
        Esophageal melanoma
        Esophagus lymphoma
        Malignant Esophageal Neoplasm by Anatomic Region
        Malignant Esophageal Neoplasm by Topographic Region
        Metastatic Malignant Neoplasm in the Esophagus
        Non-Neoplastic Esophageal Disorder
        Esophageal duplication
        Esophageal Infection
        Esophageal Mucositis
        Esophageal varix
        Esophageal web
        Megaesophagus
        Ulcer of esophagus
        Perforation of esophagus
        Mallory-Weiss syndrome

Professional guidelines

PubMed

Noncardiac chest pain: update on the diagnosis and management.

Min YW, Rhee PL
Korean J Gastroenterol 2015 Feb;65(2):76-84. doi: 10.4166/kjg.2015.65.2.76. PMID: 25716709

Achalasia: an overview of diagnosis and treatment.

Pohl D, Tutuian R
J Gastrointestin Liver Dis 2007 Sep;16(3):297-303. PMID: 17925926

A critical approach to noncardiac chest pain: pathophysiology, diagnosis, and treatment.

Fang J, Bjorkman D
Am J Gastroenterol 2001 Apr;96(4):958-68. doi: 10.1111/j.1572-0241.2001.03678.x. PMID: 11316212

See all (10)

Recent clinical studies

Etiology

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD).

Herdiana Y
Nutrients 2023 Aug 15;15(16) doi: 10.3390/nu15163583. PMID: 37630773 Free PMC Article

Gastroesophageal Reflux and Esophageal Motility Disorder After Lung Transplant: Influence on the Transplanted Graft.

de Pablo A, Alonso R, Ciriza C, Lopez E, Canga F, Juarros L, Gamez P, Perez V
Transplant Proc 2021 Jul-Aug;53(6):1989-1997. Epub 2021 May 14 doi: 10.1016/j.transproceed.2021.03.035. PMID: 33994181

The Role of Esophageal Hypersensitivity in Functional Heartburn.

Kondo T, Miwa H
J Clin Gastroenterol 2017 Aug;51(7):571-578. doi: 10.1097/MCG.0000000000000885. PMID: 28682989

White Paper AGA: Drug Development for Eosinophilic Esophagitis.

Hirano I, Spechler S, Furuta G, Dellon ES
Clin Gastroenterol Hepatol 2017 Aug;15(8):1173-1183. Epub 2017 Mar 22 doi: 10.1016/j.cgh.2017.03.016. PMID: 28342955 Free PMC Article

Eosinophilic esophagitis: an autoimmune esophageal disorder.

Malhotra N, Levine J
Curr Probl Pediatr Adolesc Health Care 2014 Dec;44(11):335-40. doi: 10.1016/j.cppeds.2014.10.004. PMID: 25499460

See all (40)

Diagnosis

Robotic Surgery in Achalasia: State of the Art.

Palomba G, Capuano M, Basile R, Sorrentino G, Fernicola A, Anoldo P, Milone M, De GD, Aprea G
Chirurgia (Bucur) 2023 Feb;118(1):8-19. doi: 10.21614/chirurgia.2830. PMID: 36913413

Nonerosive reflux disease: clinical concepts.

Gyawali CP, Azagury DE, Chan WW, Chandramohan SM, Clarke JO, de Bortoli N, Figueredo E, Fox M, Jodorkovsky D, Lazarescu A, Malfertheiner P, Martinek J, Murayama KM, Penagini R, Savarino E, Shetler KP, Stein E, Tatum RP, Wu J
Ann N Y Acad Sci 2018 Dec;1434(1):290-303. Epub 2018 May 15 doi: 10.1111/nyas.13845. PMID: 29761528

Functional disorders of swallowing.

Baumann A, Katz PO
Handb Clin Neurol 2016;139:483-488. doi: 10.1016/B978-0-12-801772-2.00039-4. PMID: 27719865

Duodenogastro-oesophageal reflux.

Vaezi MF, Richter JE
Baillieres Best Pract Res Clin Gastroenterol 2000 Oct;14(5):719-29. doi: 10.1053/bega.2000.0120. PMID: 11003805

Recent studies of the pathophysiology and diagnosis of esophageal symptoms.

Vantrappen G, Janssens J
Scand J Gastroenterol Suppl 1990;175:34-41. doi: 10.3109/00365529009093125. PMID: 2237280

See all (58)

Therapy

Robotic Surgery in Achalasia: State of the Art.

Palomba G, Capuano M, Basile R, Sorrentino G, Fernicola A, Anoldo P, Milone M, De GD, Aprea G
Chirurgia (Bucur) 2023 Feb;118(1):8-19. doi: 10.21614/chirurgia.2830. PMID: 36913413

Gastroesophageal Reflux and Esophageal Motility Disorder After Lung Transplant: Influence on the Transplanted Graft.

de Pablo A, Alonso R, Ciriza C, Lopez E, Canga F, Juarros L, Gamez P, Perez V
Transplant Proc 2021 Jul-Aug;53(6):1989-1997. Epub 2021 May 14 doi: 10.1016/j.transproceed.2021.03.035. PMID: 33994181

Emerging drugs for eosinophilic esophagitis.

Kern E, Hirano I
Expert Opin Emerg Drugs 2013 Sep;18(3):353-64. Epub 2013 Aug 13 doi: 10.1517/14728214.2013.829039. PMID: 23937314

Duodenogastro-oesophageal reflux.

Vaezi MF, Richter JE
Baillieres Best Pract Res Clin Gastroenterol 2000 Oct;14(5):719-29. doi: 10.1053/bega.2000.0120. PMID: 11003805

Odynophagia/dysphagia in AIDS.

Raufman JP
Gastroenterol Clin North Am 1988 Sep;17(3):599-614. PMID: 3049365

See all (28)

Prognosis

Gastroesophageal Reflux and Esophageal Motility Disorder After Lung Transplant: Influence on the Transplanted Graft.

de Pablo A, Alonso R, Ciriza C, Lopez E, Canga F, Juarros L, Gamez P, Perez V
Transplant Proc 2021 Jul-Aug;53(6):1989-1997. Epub 2021 May 14 doi: 10.1016/j.transproceed.2021.03.035. PMID: 33994181

Eosinophilic esophagitis: an autoimmune esophageal disorder.

Malhotra N, Levine J
Curr Probl Pediatr Adolesc Health Care 2014 Dec;44(11):335-40. doi: 10.1016/j.cppeds.2014.10.004. PMID: 25499460

Achalasia: an overview of diagnosis and treatment.

Pohl D, Tutuian R
J Gastrointestin Liver Dis 2007 Sep;16(3):297-303. PMID: 17925926

A critical approach to noncardiac chest pain: pathophysiology, diagnosis, and treatment.

Fang J, Bjorkman D
Am J Gastroenterol 2001 Apr;96(4):958-68. doi: 10.1111/j.1572-0241.2001.03678.x. PMID: 11316212

Duodenogastro-oesophageal reflux.

Vaezi MF, Richter JE
Baillieres Best Pract Res Clin Gastroenterol 2000 Oct;14(5):719-29. doi: 10.1053/bega.2000.0120. PMID: 11003805

See all (15)

Clinical prediction guides

Robotic Surgery in Achalasia: State of the Art.

Palomba G, Capuano M, Basile R, Sorrentino G, Fernicola A, Anoldo P, Milone M, De GD, Aprea G
Chirurgia (Bucur) 2023 Feb;118(1):8-19. doi: 10.21614/chirurgia.2830. PMID: 36913413

Gastroesophageal Reflux and Esophageal Motility Disorder After Lung Transplant: Influence on the Transplanted Graft.

de Pablo A, Alonso R, Ciriza C, Lopez E, Canga F, Juarros L, Gamez P, Perez V
Transplant Proc 2021 Jul-Aug;53(6):1989-1997. Epub 2021 May 14 doi: 10.1016/j.transproceed.2021.03.035. PMID: 33994181

Esophageal foreign bodies: observational cohort study and factors associated with recurrent impaction.

Ferrari D, Siboni S, Riva CG, Aiolfi A, Panici Tonucci T, Asti E, Bonavina L
Eur J Gastroenterol Hepatol 2020 Jul;32(7):827-831. doi: 10.1097/MEG.0000000000001717. PMID: 32243348

The assessment of the esophageal motility of children with esophageal disorders by the detailed observation of the pH-multichannel intraluminal impedance waveform and baseline impedance: screening test potential.

Masui D, Fukahori S, Ishii S, Hashizume N, Saikusa N, Yoshida M, Higashidate N, Sakamoto S, Tsuruhisa S, Nakahara H, Tanaka Y, Yagi M
Esophagus 2019 Apr;16(2):133-140. Epub 2018 Aug 25 doi: 10.1007/s10388-018-0640-x. PMID: 30145680

Eosinophilic esophagitis: an autoimmune esophageal disorder.

Malhotra N, Levine J
Curr Probl Pediatr Adolesc Health Care 2014 Dec;44(11):335-40. doi: 10.1016/j.cppeds.2014.10.004. PMID: 25499460

See all (15)

Recent systematic reviews

Radiation burden in patients with esophageal atresia: a systematic review.

Comella A, Tan Tanny SP, Hutson JM, Omari TI, Teague WJ, Nataraja RM, King SK
Pediatr Surg Int 2021 Jul;37(7):919-927. Epub 2021 Apr 10 doi: 10.1007/s00383-021-04892-4. PMID: 33839909

PERORAL (POEM) OR SURGICAL MYOTOMY FOR THE TREATMENT OF ACHALASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Martins RK, Ribeiro IB, DE Moura DTH, Hathorn KE, Bernardo WM, DE Moura EGH
Arq Gastroenterol 2020 Jan-Mar;57(1):79-86. doi: 10.1590/S0004-2803.202000000-14. PMID: 32294740

Natural history of eosinophilic esophagitis: a systematic review of epidemiology and disease course.

Shaheen NJ, Mukkada V, Eichinger CS, Schofield H, Todorova L, Falk GW
Dis Esophagus 2018 Aug 1;31(8) doi: 10.1093/dote/doy015. PMID: 29617744 Free PMC Article

See all (3)

MedGen

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Esophageal disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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