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Low alkaline phosphatase of renal origin

MedGen UID:
869314
•Concept ID:
C4023740
•
Finding
Synonym: Low ALP of renal origin
 
HPO: HP:0010685

Definition

An abnormally reduced level of kidney isoforms of alkaline phosphatase in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow alkaline phosphatase of renal origin

Recent clinical studies

Etiology

Biochemical analysis of cystic fluid in the diagnosis of fetal intra-abdominal masses.
Lecarpentier E, Dreux S, Blanc T, Schaub B, Ville Y, Mandelbrot L, El Ghoneimi A, Oury JF, Muller F
Prenat Diagn 2012 Jul;32(7):627-31. Epub 2012 May 4 doi: 10.1002/pd.3871. PMID: 22565808
Improvement of anemia after parathyroidectomy in Chinese patients with renal failure undergoing long-term dialysis.
Chow TL, Chan TT, Ho YW, Lam SH
Arch Surg 2007 Jul;142(7):644-8. doi: 10.1001/archsurg.142.7.644. PMID: 17638802
The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE
J Bone Miner Res 2003 Apr;18(4):615-23. doi: 10.1359/jbmr.2003.18.4.615. PMID: 12674322
Factors affecting bone mineral density in renal transplant patients.
Caglar M, Adeera L
Ann Nucl Med 1999 Jun;13(3):141-5. doi: 10.1007/BF03164853. PMID: 10435373
Urinary enzymes and low-molecular-mass proteins as indicators of diabetic nephropathy.
Jung K, Pergande M, Schimke E, Ratzmann KP, Ilius A
Clin Chem 1988 Mar;34(3):544-7. PMID: 2894906

Diagnosis

Challenging case of tumour-induced osteomalacia.
Kumar P, Jadhav DV, Ravat SH, Jain N
BMJ Case Rep 2022 May 19;15(5) doi: 10.1136/bcr-2022-249200. PMID: 35589273Free PMC Article
Osteomalacia caused by atypical renal tubular acidosis with vitamin D deficiency: a case report.
Takedani K, Notsu M, Koike S, Yamauchi M, Mori T, Sohara E, Yamauchi A, Yoshikane K, Ito T, Kanasaki K
CEN Case Rep 2021 May;10(2):294-300. Epub 2021 Jan 4 doi: 10.1007/s13730-020-00561-y. PMID: 33398781Free PMC Article
Biochemical analysis of cystic fluid in the diagnosis of fetal intra-abdominal masses.
Lecarpentier E, Dreux S, Blanc T, Schaub B, Ville Y, Mandelbrot L, El Ghoneimi A, Oury JF, Muller F
Prenat Diagn 2012 Jul;32(7):627-31. Epub 2012 May 4 doi: 10.1002/pd.3871. PMID: 22565808
Nutritional rickets and osteomalacia in school children and adolescents.
Al-Jurayyan NA, El-Desouki ME, Al-Herbish AS, Al-Mazyad AS, Al-Qhtani MM
Saudi Med J 2002 Feb;23(2):182-5. PMID: 11938395
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970

Therapy

FGF23 analysis of a Chinese family with autosomal dominant hypophosphatemic rickets.
Sun Y, Wang O, Xia W, Jiang Y, Li M, Xing X, Hu Y, Liu H, Meng X, Zhou X
J Bone Miner Metab 2012 Jan;30(1):78-84. Epub 2011 Jun 28 doi: 10.1007/s00774-011-0285-5. PMID: 21710177
The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE
J Bone Miner Res 2003 Apr;18(4):615-23. doi: 10.1359/jbmr.2003.18.4.615. PMID: 12674322
Factors affecting bone mineral density in renal transplant patients.
Caglar M, Adeera L
Ann Nucl Med 1999 Jun;13(3):141-5. doi: 10.1007/BF03164853. PMID: 10435373
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970
Rickets in children of rural origin in South Africa: is low dietary calcium a factor?
Pettifor JM, Ross P, Wang J, Moodley G, Couper-Smith J
J Pediatr 1978 Feb;92(2):320-4. doi: 10.1016/s0022-3476(78)80035-3. PMID: 202688

Prognosis

Primary billiary cirrhosis (antimitochondrial antibody negative) leading to secondary amyloidosis.
Parkash O, Almas A
J Coll Physicians Surg Pak 2012 May;22(5):330-2. PMID: 22538043
Improvement of anemia after parathyroidectomy in Chinese patients with renal failure undergoing long-term dialysis.
Chow TL, Chan TT, Ho YW, Lam SH
Arch Surg 2007 Jul;142(7):644-8. doi: 10.1001/archsurg.142.7.644. PMID: 17638802
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970
Urinary enzymes and low-molecular-mass proteins as indicators of diabetic nephropathy.
Jung K, Pergande M, Schimke E, Ratzmann KP, Ilius A
Clin Chem 1988 Mar;34(3):544-7. PMID: 2894906

Clinical prediction guides

Osteomalacia caused by atypical renal tubular acidosis with vitamin D deficiency: a case report.
Takedani K, Notsu M, Koike S, Yamauchi M, Mori T, Sohara E, Yamauchi A, Yoshikane K, Ito T, Kanasaki K
CEN Case Rep 2021 May;10(2):294-300. Epub 2021 Jan 4 doi: 10.1007/s13730-020-00561-y. PMID: 33398781Free PMC Article
FGF23 analysis of a Chinese family with autosomal dominant hypophosphatemic rickets.
Sun Y, Wang O, Xia W, Jiang Y, Li M, Xing X, Hu Y, Liu H, Meng X, Zhou X
J Bone Miner Metab 2012 Jan;30(1):78-84. Epub 2011 Jun 28 doi: 10.1007/s00774-011-0285-5. PMID: 21710177
Fas (Apo-1, CD95) receptor expression in childhood astrocytomas. Is it a marker of the major apoptotic pathway or a signaling receptor for immune escape of neoplastic cells?
Bodey B, Bodey B Jr, Siegel SE, Kaiser HE
In Vivo 1999 Jul-Aug;13(4):357-73. PMID: 10586378
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970
Urinary enzymes and low-molecular-mass proteins as indicators of diabetic nephropathy.
Jung K, Pergande M, Schimke E, Ratzmann KP, Ilius A
Clin Chem 1988 Mar;34(3):544-7. PMID: 2894906

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