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Elevated alkaline phosphatase of renal origin

MedGen UID:
869319
•Concept ID:
C4023745
•
Finding
Synonym: Elevated ALP of renal origin
 
HPO: HP:0010680

Definition

An abnormally increased level of kidney isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated alkaline phosphatase of renal origin

Recent clinical studies

Etiology

Risk Factors for Prolonged Length of Stay and Readmission After Parathyroidectomy for Renal Secondary Hyperparathyroidism.
Stefanova D, Ullmann TM, Limberg J, Moore M, Beninato T, Zarnegar R, Fahey TJ, Finnerty BM
World J Surg 2020 Nov;44(11):3751-3760. Epub 2020 Jul 31 doi: 10.1007/s00268-020-05711-y. PMID: 32737558
A comparison of TAFRO syndrome between Japanese and non-Japanese cases: a case report and literature review.
Coutier F, Meaux Ruault N, Crepin T, Bouiller K, Gil H, Humbert S, Bedgedjian I, Magy-Bertrand N
Ann Hematol 2018 Mar;97(3):401-407. Epub 2017 Sep 27 doi: 10.1007/s00277-017-3138-z. PMID: 28956126
Biochemical analysis of cystic fluid in the diagnosis of fetal intra-abdominal masses.
Lecarpentier E, Dreux S, Blanc T, Schaub B, Ville Y, Mandelbrot L, El Ghoneimi A, Oury JF, Muller F
Prenat Diagn 2012 Jul;32(7):627-31. Epub 2012 May 4 doi: 10.1002/pd.3871. PMID: 22565808
Improvement of anemia after parathyroidectomy in Chinese patients with renal failure undergoing long-term dialysis.
Chow TL, Chan TT, Ho YW, Lam SH
Arch Surg 2007 Jul;142(7):644-8. doi: 10.1001/archsurg.142.7.644. PMID: 17638802
The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE
J Bone Miner Res 2003 Apr;18(4):615-23. doi: 10.1359/jbmr.2003.18.4.615. PMID: 12674322

Diagnosis

Challenging case of tumour-induced osteomalacia.
Kumar P, Jadhav DV, Ravat SH, Jain N
BMJ Case Rep 2022 May 19;15(5) doi: 10.1136/bcr-2022-249200. PMID: 35589273Free PMC Article
A comparison of TAFRO syndrome between Japanese and non-Japanese cases: a case report and literature review.
Coutier F, Meaux Ruault N, Crepin T, Bouiller K, Gil H, Humbert S, Bedgedjian I, Magy-Bertrand N
Ann Hematol 2018 Mar;97(3):401-407. Epub 2017 Sep 27 doi: 10.1007/s00277-017-3138-z. PMID: 28956126
Fever of unknown origin (FUO) due to large B-cell lymphoma: the diagnostic significance of highly elevated alkaline phosphatase and serum ferritin levels.
Cunha BA, Petelin A
Heart Lung 2013 Jan-Feb;42(1):67-71. Epub 2012 Aug 14 doi: 10.1016/j.hrtlng.2012.05.004. PMID: 22898330
Biochemical analysis of cystic fluid in the diagnosis of fetal intra-abdominal masses.
Lecarpentier E, Dreux S, Blanc T, Schaub B, Ville Y, Mandelbrot L, El Ghoneimi A, Oury JF, Muller F
Prenat Diagn 2012 Jul;32(7):627-31. Epub 2012 May 4 doi: 10.1002/pd.3871. PMID: 22565808
Elevated serum alkaline phosphatase levels in a renal transplant patient precede colitis.
Korzets A, Zevin D, Ori Y, Herman M, Chagnac A, Gafter U
Transpl Infect Dis 2006 Sep;8(3):157-60. doi: 10.1111/j.1399-3062.2006.00121.x. PMID: 16913974

Therapy

Risk Factors for Prolonged Length of Stay and Readmission After Parathyroidectomy for Renal Secondary Hyperparathyroidism.
Stefanova D, Ullmann TM, Limberg J, Moore M, Beninato T, Zarnegar R, Fahey TJ, Finnerty BM
World J Surg 2020 Nov;44(11):3751-3760. Epub 2020 Jul 31 doi: 10.1007/s00268-020-05711-y. PMID: 32737558
Nimesulide-induced fatal acute liver failure in an elderly woman with metastatic biliary adenocarcinoma. A case report.
Bernardes SS, Souza-Nogueira A, Moreira EG, Kishima MO, Guembarovski AF, Turini TL, Turini CA
Sao Paulo Med J 2015 Jul-Aug;133(4):371-6. Epub 2014 Sep 19 doi: 10.1590/1516-3180.2013.7550003. PMID: 25250798Free PMC Article
FGF23 analysis of a Chinese family with autosomal dominant hypophosphatemic rickets.
Sun Y, Wang O, Xia W, Jiang Y, Li M, Xing X, Hu Y, Liu H, Meng X, Zhou X
J Bone Miner Metab 2012 Jan;30(1):78-84. Epub 2011 Jun 28 doi: 10.1007/s00774-011-0285-5. PMID: 21710177
The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE
J Bone Miner Res 2003 Apr;18(4):615-23. doi: 10.1359/jbmr.2003.18.4.615. PMID: 12674322
Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity.
Puchalski TA, Ryan DP, Garcia-Carbonero R, Demetri GD, Butkiewicz L, Harmon D, Seiden MV, Maki RG, Lopez-Lazaro L, Jimeno J, Guzman C, Supko JG
Cancer Chemother Pharmacol 2002 Oct;50(4):309-19. Epub 2002 Jul 31 doi: 10.1007/s00280-002-0498-3. PMID: 12357306

Prognosis

Risk Factors for Prolonged Length of Stay and Readmission After Parathyroidectomy for Renal Secondary Hyperparathyroidism.
Stefanova D, Ullmann TM, Limberg J, Moore M, Beninato T, Zarnegar R, Fahey TJ, Finnerty BM
World J Surg 2020 Nov;44(11):3751-3760. Epub 2020 Jul 31 doi: 10.1007/s00268-020-05711-y. PMID: 32737558
Nimesulide-induced fatal acute liver failure in an elderly woman with metastatic biliary adenocarcinoma. A case report.
Bernardes SS, Souza-Nogueira A, Moreira EG, Kishima MO, Guembarovski AF, Turini TL, Turini CA
Sao Paulo Med J 2015 Jul-Aug;133(4):371-6. Epub 2014 Sep 19 doi: 10.1590/1516-3180.2013.7550003. PMID: 25250798Free PMC Article
Improvement of anemia after parathyroidectomy in Chinese patients with renal failure undergoing long-term dialysis.
Chow TL, Chan TT, Ho YW, Lam SH
Arch Surg 2007 Jul;142(7):644-8. doi: 10.1001/archsurg.142.7.644. PMID: 17638802
Hyperamylasemia in patients with the acquired immunodeficiency syndrome.
Murthy UK, DeGregorio F, Oates RP, Blair DC
Am J Gastroenterol 1992 Mar;87(3):332-6. PMID: 1371638
Clinical significance of hyperparathyroidism in familial multiple endocrine adenomatosis type I (MEA I).
Lamers CB, Froeling PG
Am J Med 1979 Mar;66(3):422-4. doi: 10.1016/0002-9343(79)91062-3. PMID: 34999

Clinical prediction guides

Risk Factors for Prolonged Length of Stay and Readmission After Parathyroidectomy for Renal Secondary Hyperparathyroidism.
Stefanova D, Ullmann TM, Limberg J, Moore M, Beninato T, Zarnegar R, Fahey TJ, Finnerty BM
World J Surg 2020 Nov;44(11):3751-3760. Epub 2020 Jul 31 doi: 10.1007/s00268-020-05711-y. PMID: 32737558
FGF23 analysis of a Chinese family with autosomal dominant hypophosphatemic rickets.
Sun Y, Wang O, Xia W, Jiang Y, Li M, Xing X, Hu Y, Liu H, Meng X, Zhou X
J Bone Miner Metab 2012 Jan;30(1):78-84. Epub 2011 Jun 28 doi: 10.1007/s00774-011-0285-5. PMID: 21710177
Hyperamylasemia in patients with the acquired immunodeficiency syndrome.
Murthy UK, DeGregorio F, Oates RP, Blair DC
Am J Gastroenterol 1992 Mar;87(3):332-6. PMID: 1371638

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