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Hypertrophy of the lower limb

MedGen UID:
869376
•Concept ID:
C4023803
•
Finding
Synonyms: Hypertrophy of leg; Hypertrophy of lower extremity; Hypertrophy of lower limb
SNOMED CT: Hypertrophy of lower limb (1268319002); Hypertrophy of leg (1268319002); Hypertrophy of lower extremity (1268319002)
 
HPO: HP:0010496

Definition

Abnormal increase in size of the lower limbs (due to an increase of the size of cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertrophy of the lower limb

Professional guidelines

PubMed

Management of Musculoskeletal Complications in Patients with Hemophilia: Literature Review and Expert Recommendations.
Rodriguez-Merchan EC
Cardiovasc Hematol Disord Drug Targets 2021;21(3):162-166. doi: 10.2174/1871529X21666210427134232. PMID: 33906595
Klippel-Trenaunay syndrome: current management.
Gloviczki P, Driscoll DJ
Phlebology 2007;22(6):291-8. doi: 10.1177/026835550702200611. PMID: 18274338
Management of ingrown toenails.
Zuber TJ, Pfenninger JL
Am Fam Physician 1995 Jul;52(1):181-90. PMID: 7604762

Recent clinical studies

Etiology

Effects of the Short-Foot Exercise on Foot Alignment and Muscle Hypertrophy in Flatfoot Individuals: A Meta-Analysis.
Huang C, Chen LY, Liao YH, Masodsai K, Lin YY
Int J Environ Res Public Health 2022 Sep 22;19(19) doi: 10.3390/ijerph191911994. PMID: 36231295Free PMC Article
Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations.
Plotkin D, Coleman M, Van Every D, Maldonado J, Oberlin D, Israetel M, Feather J, Alto A, Vigotsky AD, Schoenfeld BJ
PeerJ 2022;10:e14142. Epub 2022 Sep 30 doi: 10.7717/peerj.14142. PMID: 36199287Free PMC Article
Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men.
Schoenfeld BJ, Contreras B, Krieger J, Grgic J, Delcastillo K, Belliard R, Alto A
Med Sci Sports Exerc 2019 Jan;51(1):94-103. doi: 10.1249/MSS.0000000000001764. PMID: 30153194Free PMC Article
Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.
Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnaiter JA, Bond-Williams KE, Carter AS, Ross CL, Just BL, Henselmans M, Krieger JW
J Strength Cond Res 2016 Jul;30(7):1805-12. doi: 10.1519/JSC.0000000000001272. PMID: 26605807
Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms.
Ozaki H, Loenneke JP, Thiebaud RS, Abe T
Acta Physiol Hung 2015 Mar;102(1):1-22. doi: 10.1556/APhysiol.102.2015.1.1. PMID: 25804386

Diagnosis

Role of imaging techniques in the diagnosis of selective hypertrophy of the tensor fascia lata.
Pumar Pérez M, Marsico S, Rodríguez Baeza A, Solano López A
Radiologia (Engl Ed) 2022 Jul-Aug;64(4):368-374. doi: 10.1016/j.rxeng.2021.06.006. PMID: 36030083
Caveolinopathies in Greece.
Papadopoulos C, Papadimas GK, Kekou K, Spengos K, Svigou M, Kitsiou-Tzeli S, Manta P
Neurologist 2015 Jul;20(1):8-12. doi: 10.1097/NRL.0000000000000036. PMID: 26185955
Athlete's nodule.
Uchiyama M, Tsuboi R, Mitsuhashi Y
J Dermatol 2009 Nov;36(11):608-11. doi: 10.1111/j.1346-8138.2009.00718.x. PMID: 19878395
Piriformis muscle syndrome.
Kuncewicz E, Gajewska E, Sobieska M, Samborski W
Ann Acad Med Stetin 2006;52(3):99-101; discussion 101. PMID: 17385355
Surgical nail procedures.
Caprioli R, Bilotti MA
Clin Podiatr Med Surg 1989 Apr;6(2):431-51. PMID: 2650852

Therapy

Effects of the Short-Foot Exercise on Foot Alignment and Muscle Hypertrophy in Flatfoot Individuals: A Meta-Analysis.
Huang C, Chen LY, Liao YH, Masodsai K, Lin YY
Int J Environ Res Public Health 2022 Sep 22;19(19) doi: 10.3390/ijerph191911994. PMID: 36231295Free PMC Article
Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations.
Plotkin D, Coleman M, Van Every D, Maldonado J, Oberlin D, Israetel M, Feather J, Alto A, Vigotsky AD, Schoenfeld BJ
PeerJ 2022;10:e14142. Epub 2022 Sep 30 doi: 10.7717/peerj.14142. PMID: 36199287Free PMC Article
Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men.
Schoenfeld BJ, Contreras B, Krieger J, Grgic J, Delcastillo K, Belliard R, Alto A
Med Sci Sports Exerc 2019 Jan;51(1):94-103. doi: 10.1249/MSS.0000000000001764. PMID: 30153194Free PMC Article
Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.
Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnaiter JA, Bond-Williams KE, Carter AS, Ross CL, Just BL, Henselmans M, Krieger JW
J Strength Cond Res 2016 Jul;30(7):1805-12. doi: 10.1519/JSC.0000000000001272. PMID: 26605807
Cycle training induces muscle hypertrophy and strength gain: strategies and mechanisms.
Ozaki H, Loenneke JP, Thiebaud RS, Abe T
Acta Physiol Hung 2015 Mar;102(1):1-22. doi: 10.1556/APhysiol.102.2015.1.1. PMID: 25804386

Prognosis

Overview of arterial pathology related to repetitive trauma in athletes.
Menon D, Onida S, Davies AH
J Vasc Surg 2019 Aug;70(2):641-650. Epub 2019 May 18 doi: 10.1016/j.jvs.2019.02.002. PMID: 31113722
Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Athlete's nodule.
Uchiyama M, Tsuboi R, Mitsuhashi Y
J Dermatol 2009 Nov;36(11):608-11. doi: 10.1111/j.1346-8138.2009.00718.x. PMID: 19878395
Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients.
Kley RA, Hellenbroich Y, van der Ven PF, Fürst DO, Huebner A, Bruchertseifer V, Peters SA, Heyer CM, Kirschner J, Schröder R, Fischer D, Müller K, Tolksdorf K, Eger K, Germing A, Brodherr T, Reum C, Walter MC, Lochmüller H, Ketelsen UP, Vorgerd M
Brain 2007 Dec;130(Pt 12):3250-64. doi: 10.1093/brain/awm271. PMID: 18055494
Vascular anomalies and the growth of limbs: a review.
Enjolras O, Chapot R, Merland JJ
J Pediatr Orthop B 2004 Nov;13(6):349-57. doi: 10.1097/01202412-200411000-00001. PMID: 15599224

Clinical prediction guides

Effects of the Short-Foot Exercise on Foot Alignment and Muscle Hypertrophy in Flatfoot Individuals: A Meta-Analysis.
Huang C, Chen LY, Liao YH, Masodsai K, Lin YY
Int J Environ Res Public Health 2022 Sep 22;19(19) doi: 10.3390/ijerph191911994. PMID: 36231295Free PMC Article
Effect of different training frequencies on maximal strength performance and muscle hypertrophy in trained individuals-a within-subject design.
Neves RP, Vechin FC, Teixeira EL, da Silva DD, Ugrinowitsch C, Roschel H, Aihara AY, Tricoli V
PLoS One 2022;17(10):e0276154. Epub 2022 Oct 13 doi: 10.1371/journal.pone.0276154. PMID: 36228016Free PMC Article
Progressive overload without progressing load? The effects of load or repetition progression on muscular adaptations.
Plotkin D, Coleman M, Van Every D, Maldonado J, Oberlin D, Israetel M, Feather J, Alto A, Vigotsky AD, Schoenfeld BJ
PeerJ 2022;10:e14142. Epub 2022 Sep 30 doi: 10.7717/peerj.14142. PMID: 36199287Free PMC Article
Muscle Failure Promotes Greater Muscle Hypertrophy in Low-Load but Not in High-Load Resistance Training.
Lasevicius T, Schoenfeld BJ, Silva-Batista C, Barros TS, Aihara AY, Brendon H, Longo AR, Tricoli V, Peres BA, Teixeira EL
J Strength Cond Res 2022 Feb 1;36(2):346-351. doi: 10.1519/JSC.0000000000003454. PMID: 31895290
Rest-pause and drop-set training elicit similar strength and hypertrophy adaptations compared with traditional sets in resistance-trained males.
Enes A, Alves RC, Schoenfeld BJ, Oneda G, Perin SC, Trindade TB, Prestes J, Souza-Junior TP
Appl Physiol Nutr Metab 2021 Nov;46(11):1417-1424. Epub 2021 Jul 14 doi: 10.1139/apnm-2021-0278. PMID: 34260860

Recent systematic reviews

Diagnostic imaging in lipedema: A systematic review.
van la Parra RFD, Deconinck C, Krug B
Obes Rev 2024 Jan;25(1):e13648. Epub 2023 Oct 3 doi: 10.1111/obr.13648. PMID: 37789512
Chronic Adaptations to Eccentric Cycling Training: A Systematic Review and Meta-Analysis.
Barreto RV, de Lima LCR, Borszcz FK, de Lucas RD, Denadai BS
Int J Environ Res Public Health 2023 Feb 6;20(4) doi: 10.3390/ijerph20042861. PMID: 36833557Free PMC Article
Effects of range of motion on resistance training adaptations: A systematic review and meta-analysis.
Pallarés JG, Hernández-Belmonte A, Martínez-Cava A, Vetrovsky T, Steffl M, Courel-Ibáñez J
Scand J Med Sci Sports 2021 Oct;31(10):1866-1881. Epub 2021 Jul 5 doi: 10.1111/sms.14006. PMID: 34170576
How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency.
Schoenfeld BJ, Grgic J, Krieger J
J Sports Sci 2019 Jun;37(11):1286-1295. Epub 2018 Dec 17 doi: 10.1080/02640414.2018.1555906. PMID: 30558493
Subungual exostosis of the toes: a systematic review.
DaCambra MP, Gupta SK, Ferri-de-Barros F
Clin Orthop Relat Res 2014 Apr;472(4):1251-9. Epub 2013 Oct 22 doi: 10.1007/s11999-013-3345-4. PMID: 24146360Free PMC Article

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