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Abnormal 2nd metacarpal morphology

MedGen UID:
869685
•Concept ID:
C4024113
•
Anatomical Abnormality
Synonyms: Abnormality of the 2nd long bone of hand; Abnormality of the 2nd metacarpal
 
HPO: HP:0010010

Definition

Any abnormality of the second metacarpal bone. [from HPO]

Recent clinical studies

Etiology

Metacarpophalangeal pattern profile and bone age in Rett syndrome: further radiological clues to the diagnosis.
Leonard H, Thomson M, Glasson E, Fyfe S, Leonard S, Ellaway C, Christodoulou J, Bower C
Am J Med Genet 1999 Mar 12;83(2):88-95. doi: 10.1002/(sici)1096-8628(19990312)83:2<88::aid-ajmg3>3.0.co;2-7. PMID: 10190478
Antithyroid therapy improves bony manifestations and bone metabolic markers in patients with Graves' thyrotoxicosis.
Nagasaka S, Sugimoto H, Nakamura T, Kusaka I, Fujisawa G, Sakuma N, Tsuboi Y, Fukuda S, Honda K, Okada K, Ishikawa S, Saito T
Clin Endocrinol (Oxf) 1997 Aug;47(2):215-21. doi: 10.1046/j.1365-2265.1997.2401045.x. PMID: 9302397
Stringent delineation of Pallister-Hall syndrome in two long surviving patients: importance of radiological anomalies of the hands.
Verloes A, David A, Ngô L, Bottani A
J Med Genet 1995 Aug;32(8):605-11. doi: 10.1136/jmg.32.8.605. PMID: 7473651Free PMC Article

Diagnosis

That's my STYLEoideum - Symptomatic os styloideum in an adolescent male.
Kaniewska M, Haefeli M, Laesser U, Niemann T
J Radiol Case Rep 2017 Jul;11(7):14-19. Epub 2017 Jul 31 doi: 10.3941/jrcr.v11i7.2877. PMID: 29299098Free PMC Article
Metacarpophalangeal pattern profile and bone age in Rett syndrome: further radiological clues to the diagnosis.
Leonard H, Thomson M, Glasson E, Fyfe S, Leonard S, Ellaway C, Christodoulou J, Bower C
Am J Med Genet 1999 Mar 12;83(2):88-95. doi: 10.1002/(sici)1096-8628(19990312)83:2<88::aid-ajmg3>3.0.co;2-7. PMID: 10190478
Stringent delineation of Pallister-Hall syndrome in two long surviving patients: importance of radiological anomalies of the hands.
Verloes A, David A, Ngô L, Bottani A
J Med Genet 1995 Aug;32(8):605-11. doi: 10.1136/jmg.32.8.605. PMID: 7473651Free PMC Article

Therapy

Antithyroid therapy improves bony manifestations and bone metabolic markers in patients with Graves' thyrotoxicosis.
Nagasaka S, Sugimoto H, Nakamura T, Kusaka I, Fujisawa G, Sakuma N, Tsuboi Y, Fukuda S, Honda K, Okada K, Ishikawa S, Saito T
Clin Endocrinol (Oxf) 1997 Aug;47(2):215-21. doi: 10.1046/j.1365-2265.1997.2401045.x. PMID: 9302397
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Antithyroid therapy improves bony manifestations and bone metabolic markers in patients with Graves' thyrotoxicosis.
Nagasaka S, Sugimoto H, Nakamura T, Kusaka I, Fujisawa G, Sakuma N, Tsuboi Y, Fukuda S, Honda K, Okada K, Ishikawa S, Saito T
Clin Endocrinol (Oxf) 1997 Aug;47(2):215-21. doi: 10.1046/j.1365-2265.1997.2401045.x. PMID: 9302397
Stringent delineation of Pallister-Hall syndrome in two long surviving patients: importance of radiological anomalies of the hands.
Verloes A, David A, Ngô L, Bottani A
J Med Genet 1995 Aug;32(8):605-11. doi: 10.1136/jmg.32.8.605. PMID: 7473651Free PMC Article

Clinical prediction guides

Metacarpophalangeal pattern profile and bone age in Rett syndrome: further radiological clues to the diagnosis.
Leonard H, Thomson M, Glasson E, Fyfe S, Leonard S, Ellaway C, Christodoulou J, Bower C
Am J Med Genet 1999 Mar 12;83(2):88-95. doi: 10.1002/(sici)1096-8628(19990312)83:2<88::aid-ajmg3>3.0.co;2-7. PMID: 10190478
Antithyroid therapy improves bony manifestations and bone metabolic markers in patients with Graves' thyrotoxicosis.
Nagasaka S, Sugimoto H, Nakamura T, Kusaka I, Fujisawa G, Sakuma N, Tsuboi Y, Fukuda S, Honda K, Okada K, Ishikawa S, Saito T
Clin Endocrinol (Oxf) 1997 Aug;47(2):215-21. doi: 10.1046/j.1365-2265.1997.2401045.x. PMID: 9302397
Stringent delineation of Pallister-Hall syndrome in two long surviving patients: importance of radiological anomalies of the hands.
Verloes A, David A, Ngô L, Bottani A
J Med Genet 1995 Aug;32(8):605-11. doi: 10.1136/jmg.32.8.605. PMID: 7473651Free PMC Article
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

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