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Abnormality of secondary sexual hair

MedGen UID:
869742
•Concept ID:
C4024171
•
Finding
HPO: HP:0009888

Definition

Abnormality of the growth of secondary sexual hair, which normally ensues during puberty. In males, secondary sexual hair usually comprises body hair, including underarm, abdominal, chest, and pubic hair. In females, secondary sexual hair usually comprises a lesser degree of body hair, most prominently underarm and pubic hair. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of secondary sexual hair

Recent clinical studies

Etiology

Validation of 11 added items of the outpatient version of the Utrecht Symptom Diary in patients receiving chemotherapy or targeted therapy.
Koldenhof JJ, Akpobome BO, Zweers D, Klaasse S, Teunissen SCCM, Witteveen PO, Suijkerbuijk KPM, de Graeff A, van der Baan FH
J Patient Rep Outcomes 2024 Oct 18;8(1):120. doi: 10.1186/s41687-024-00794-w. PMID: 39422800Free PMC Article
Clinical Features of 32 Patients with XO/XY Gonadal Dysgenesis.
Jiang JF, Tian QJ, Xue W, Deng Y, Zheng TP, Sun AJ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Aug;38(4):411-4. doi: 10.3881/j.issn.1000-503X.2016.04.008. PMID: 27594153
Considerations for androgen therapy in children and adolescents with Klinefelter syndrome (47, XXY).
Rogol AD, Tartaglia N
Pediatr Endocrinol Rev 2010 Dec;8 Suppl 1:145-50. PMID: 21217606
Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels.
Bannink EM, van Sassen C, van Buuren S, de Jong FH, Lequin M, Mulder PG, de Muinck Keizer-Schrama SM
Clin Endocrinol (Oxf) 2009 Feb;70(2):265-73. doi: 10.1111/j.1365-2265.2008.03446.x. PMID: 19200215
Turner syndrome diagnosed in northeastern Malaysia.
Kannan TP, Azman BZ, Ahmad Tarmizi AB, Suhaida MA, Siti Mariam I, Ravindran A, Zilfalil BA
Singapore Med J 2008 May;49(5):400-4. PMID: 18465051

Diagnosis

Congenital adrenal hyperplasia complicated by gonadotropin-dependent precocious puberty.
Alam A, Agrawal NK, Singh SK
BMJ Case Rep 2024 Mar 4;17(3) doi: 10.1136/bcr-2023-257579. PMID: 38442976Free PMC Article
Noonan Syndrome Presenting with Stunted Growth: A Case Report.
Mondal E, Chanda PK, Musabber NA, Haque MA, Robel AB, Deb PK, Biswas H, Moshwan MM, Azad U, Kamrul-Hasan AB
Mymensingh Med J 2022 Jan;31(1):263-266. PMID: 34999713
Androgenization in Klinefelter syndrome: Clinical spectrum from infancy through young adulthood.
Nassau DE, Best JC, Cohen J, Gonzalez DC, Alam A, Ramasamy R
J Pediatr Urol 2021 Jun;17(3):346-352. Epub 2021 Feb 24 doi: 10.1016/j.jpurol.2021.02.021. PMID: 33726973
Achondroplasia associated with gonadal dysgenesis.
Gokce C, Atabek ME, Kaynar L, Torun E, Kurtoglu S, Bayram F
J Int Med Res 2008 May-Jun;36(3):605-8. doi: 10.1177/147323000803600329. PMID: 18534146
Molecular basis of androgen insensitivity.
Brinkmann AO
Mol Cell Endocrinol 2001 Jun 20;179(1-2):105-9. doi: 10.1016/s0303-7207(01)00466-x. PMID: 11420135

Therapy

Validation of 11 added items of the outpatient version of the Utrecht Symptom Diary in patients receiving chemotherapy or targeted therapy.
Koldenhof JJ, Akpobome BO, Zweers D, Klaasse S, Teunissen SCCM, Witteveen PO, Suijkerbuijk KPM, de Graeff A, van der Baan FH
J Patient Rep Outcomes 2024 Oct 18;8(1):120. doi: 10.1186/s41687-024-00794-w. PMID: 39422800Free PMC Article
Testosterone replacement therapy to improve secondary sexual characteristics and body composition without adverse behavioral problems in adult male patients with Prader-Willi syndrome: an observational study.
Kido Y, Sakazume S, Abe Y, Oto Y, Itabashi H, Shiraishi M, Yoshino A, Tanaka Y, Obata K, Murakami N, Nagai T
Am J Med Genet A 2013 Sep;161A(9):2167-73. Epub 2013 Jul 29 doi: 10.1002/ajmg.a.36048. PMID: 23897656
46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma.
Velasco G, Savarese V, Sandorfi N, Jimenez SA, Jabbour S
Endocr Pract 2011 Jan-Feb;17(1):95-8. doi: 10.4158/EP10184.CR. PMID: 20841307
Considerations for androgen therapy in children and adolescents with Klinefelter syndrome (47, XXY).
Rogol AD, Tartaglia N
Pediatr Endocrinol Rev 2010 Dec;8 Suppl 1:145-50. PMID: 21217606
Estrogen-like endocrine disrupting chemicals affecting puberty in humans--a review.
Roy JR, Chakraborty S, Chakraborty TR
Med Sci Monit 2009 Jun;15(6):RA137-45. PMID: 19478717

Prognosis

Kallmann Syndrome Due to Heterozygous Mutation in SOX10 Coexisting With Waardenburg Syndrome Type II: Case Report and Review of Literature.
Chen K, Wang H, Lai Y
Front Endocrinol (Lausanne) 2020;11:592831. Epub 2021 Feb 1 doi: 10.3389/fendo.2020.592831. PMID: 33597923Free PMC Article
Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels.
Bannink EM, van Sassen C, van Buuren S, de Jong FH, Lequin M, Mulder PG, de Muinck Keizer-Schrama SM
Clin Endocrinol (Oxf) 2009 Feb;70(2):265-73. doi: 10.1111/j.1365-2265.2008.03446.x. PMID: 19200215
Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study.
Miyagawa Y, Tsujimura A, Matsumiya K, Takao T, Tohda A, Koga M, Takeyama M, Fujioka H, Takada S, Koide T, Okuyama A
J Urol 2005 Jun;173(6):2072-5. doi: 10.1097/01.ju.0000158133.09197.f4. PMID: 15879837
A novel mutation in the CAG triplet region of exon 1 of androgen receptor gene causes complete androgen insensitivity syndrome in a large kindred.
Zhu YS, Cai LQ, Cordero JJ, Canovatchel WJ, Katz MD, Imperato-McGinley J
J Clin Endocrinol Metab 1999 May;84(5):1590-4. doi: 10.1210/jcem.84.5.5695. PMID: 10323385
Reproductive capacity of the mentally retarded.
Salerno LJ, Park JK, Giannini MJ
J Reprod Med 1975 Mar;14(3):123-9. PMID: 165294

Clinical prediction guides

Validation of 11 added items of the outpatient version of the Utrecht Symptom Diary in patients receiving chemotherapy or targeted therapy.
Koldenhof JJ, Akpobome BO, Zweers D, Klaasse S, Teunissen SCCM, Witteveen PO, Suijkerbuijk KPM, de Graeff A, van der Baan FH
J Patient Rep Outcomes 2024 Oct 18;8(1):120. doi: 10.1186/s41687-024-00794-w. PMID: 39422800Free PMC Article
Noonan Syndrome Presenting with Stunted Growth: A Case Report.
Mondal E, Chanda PK, Musabber NA, Haque MA, Robel AB, Deb PK, Biswas H, Moshwan MM, Azad U, Kamrul-Hasan AB
Mymensingh Med J 2022 Jan;31(1):263-266. PMID: 34999713
Kallmann Syndrome Due to Heterozygous Mutation in SOX10 Coexisting With Waardenburg Syndrome Type II: Case Report and Review of Literature.
Chen K, Wang H, Lai Y
Front Endocrinol (Lausanne) 2020;11:592831. Epub 2021 Feb 1 doi: 10.3389/fendo.2020.592831. PMID: 33597923Free PMC Article
Clinical Features of 32 Patients with XO/XY Gonadal Dysgenesis.
Jiang JF, Tian QJ, Xue W, Deng Y, Zheng TP, Sun AJ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016 Aug;38(4):411-4. doi: 10.3881/j.issn.1000-503X.2016.04.008. PMID: 27594153
Molecular basis of androgen insensitivity.
Brinkmann AO
Mol Cell Endocrinol 2001 Jun 20;179(1-2):105-9. doi: 10.1016/s0303-7207(01)00466-x. PMID: 11420135

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