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Generalized weakness of limb muscles

MedGen UID:
870172
•Concept ID:
C4024605
•
Finding
Synonym: Generalised weakness of limb muscles
 
HPO: HP:0009028

Definition

Generalized weakness of the muscles of the arms and legs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Generalized weakness of limb muscles

Professional guidelines

PubMed

Clinical characteristics, treatment and outcome of nivolumab-induced myasthenia gravis.
Wang C, Zeng H, Fang W, Song L
Invest New Drugs 2023 Apr;41(2):333-339. Epub 2023 Mar 29 doi: 10.1007/s10637-023-01347-6. PMID: 36988830
Influence of frailty on treatment outcomes after revascularization in patients with critical limb ischemia.
Morisaki K, Yamaoka T, Iwasa K, Ohmine T
J Vasc Surg 2017 Dec;66(6):1758-1764. Epub 2017 Jun 21 doi: 10.1016/j.jvs.2017.04.048. PMID: 28647199
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.
Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society, Delgado MR, Hirtz D, Aisen M, Ashwal S, Fehlings DL, McLaughlin J, Morrison LA, Shrader MW, Tilton A, Vargus-Adams J
Neurology 2010 Jan 26;74(4):336-43. doi: 10.1212/WNL.0b013e3181cbcd2f. PMID: 20101040Free PMC Article

Recent clinical studies

Etiology

Virtual reality exercise programs ameliorate frailty and fall risks in older adults: A meta-analysis.
Lee YH, Lin CH, Wu WR, Chiu HY, Huang HC
J Am Geriatr Soc 2023 Sep;71(9):2946-2955. Epub 2023 May 10 doi: 10.1111/jgs.18398. PMID: 37165743
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Effects of lower limb resistance exercise on muscle strength, physical fitness, and metabolism in pre-frail elderly patients: a randomized controlled trial.
Lai X, Bo L, Zhu H, Chen B, Wu Z, Du H, Huo X
BMC Geriatr 2021 Jul 30;21(1):447. doi: 10.1186/s12877-021-02386-5. PMID: 34330211Free PMC Article
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.
Suetta C, Haddock B, Alcazar J, Noerst T, Hansen OM, Ludvig H, Kamper RS, Schnohr P, Prescott E, Andersen LL, Frandsen U, Aagaard P, Bülow J, Hovind P, Simonsen L
J Cachexia Sarcopenia Muscle 2019 Dec;10(6):1316-1329. Epub 2019 Aug 16 doi: 10.1002/jcsm.12477. PMID: 31419087Free PMC Article
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article

Diagnosis

Myasthenia Gravis and Congenital Myasthenic Syndromes.
Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.
Suetta C, Haddock B, Alcazar J, Noerst T, Hansen OM, Ludvig H, Kamper RS, Schnohr P, Prescott E, Andersen LL, Frandsen U, Aagaard P, Bülow J, Hovind P, Simonsen L
J Cachexia Sarcopenia Muscle 2019 Dec;10(6):1316-1329. Epub 2019 Aug 16 doi: 10.1002/jcsm.12477. PMID: 31419087Free PMC Article
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology.
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
Models of sarcopenia: Short review.
Palus S, Springer JI, Doehner W, von Haehling S, Anker M, Anker SD, Springer J
Int J Cardiol 2017 Jul 1;238:19-21. Epub 2017 Apr 2 doi: 10.1016/j.ijcard.2017.03.152. PMID: 28465116
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article

Therapy

Virtual reality exercise programs ameliorate frailty and fall risks in older adults: A meta-analysis.
Lee YH, Lin CH, Wu WR, Chiu HY, Huang HC
J Am Geriatr Soc 2023 Sep;71(9):2946-2955. Epub 2023 May 10 doi: 10.1111/jgs.18398. PMID: 37165743
Effects of lower limb resistance exercise on muscle strength, physical fitness, and metabolism in pre-frail elderly patients: a randomized controlled trial.
Lai X, Bo L, Zhu H, Chen B, Wu Z, Du H, Huo X
BMC Geriatr 2021 Jul 30;21(1):447. doi: 10.1186/s12877-021-02386-5. PMID: 34330211Free PMC Article
Myasthenia Gravis and Congenital Myasthenic Syndromes.
Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
Efficacy of botulinum toxin in modifying spasticity to improve walking and quality of life in post-stroke lower limb spasticity - a randomized double-blind placebo controlled study.
Datta Gupta A, Visvanathan R, Cameron I, Koblar SA, Howell S, Wilson D
BMC Neurol 2019 May 11;19(1):96. doi: 10.1186/s12883-019-1325-3. PMID: 31078139Free PMC Article
Fasciculating toxicity.
Ranjan A, Jamshed N, Aggarwal P, Upadhyay V
Am J Emerg Med 2019 Apr;37(4):798.e1-798.e2. Epub 2019 Jan 21 doi: 10.1016/j.ajem.2019.01.033. PMID: 30686539

Prognosis

Prediction of probable sarcopenia with an alternative method: plantar flexion strength.
Erken N, Dost FS, Ates Bulut E, Isik AT
Postgrad Med 2022 Aug;134(6):552-558. Epub 2022 May 6 doi: 10.1080/00325481.2022.2073027. PMID: 35500572
The Predictability of Frailty Associated with Musculoskeletal Deficits: A Longitudinal Study.
Tembo MC, Mohebbi M, Holloway-Kew KL, Gaston J, Brennan-Olsen SL, Williams LJ, Kotowicz MA, Pasco JA
Calcif Tissue Int 2021 Nov;109(5):525-533. Epub 2021 May 20 doi: 10.1007/s00223-021-00865-w. PMID: 34014355
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology.
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
Spinal muscular atrophy.
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Clinical prediction guides

Sensor-Based Assessment of Variability in Daily Physical Activity and Frailty.
Pradeep Kumar D, Najafi B, Laksari K, Toosizadeh N
Gerontology 2023;69(9):1147-1154. Epub 2023 May 10 doi: 10.1159/000530900. PMID: 37231977
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review.
Jones RL, Paul L, Steultjens MPM, Smith SL
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2791-2806. Epub 2022 Aug 17 doi: 10.1002/jcsm.13064. PMID: 35977879Free PMC Article
Age-related changes in the structure and function of skeletal muscles.
Faulkner JA, Larkin LM, Claflin DR, Brooks SV
Clin Exp Pharmacol Physiol 2007 Nov;34(11):1091-6. doi: 10.1111/j.1440-1681.2007.04752.x. PMID: 17880359
Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered.
Dekhuijzen PN, Decramer M
Eur Respir J 1992 Sep;5(8):997-1003. PMID: 1426209

Recent systematic reviews

A State-of-the-Art of Exoskeletons in Line with the WHO's Vision on Healthy Aging: From Rehabilitation of Intrinsic Capacities to Augmentation of Functional Abilities.
Gavrila Laic RA, Firouzi M, Claeys R, Bautmans I, Swinnen E, Beckwée D
Sensors (Basel) 2024 Mar 30;24(7) doi: 10.3390/s24072230. PMID: 38610440Free PMC Article
Protein intake and physical function in older adults: A systematic review and meta-analysis.
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review.
Jones RL, Paul L, Steultjens MPM, Smith SL
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2791-2806. Epub 2022 Aug 17 doi: 10.1002/jcsm.13064. PMID: 35977879Free PMC Article
Skeletal Muscle Changes in the First Three Months of Stroke Recovery: A Systematic Review.
Beckwée D, Cuypers L, Lefeber N, De Keersmaecker E, Scheys E, Van Hees W, Perkisas S, De Raedt S, Kerckhofs E, Bautmans I, Swinnen E
J Rehabil Med 2022 Oct 4;54:jrm00308. doi: 10.2340/jrm.v54.573. PMID: 35848335Free PMC Article
The influence of strength training on muscle activation in elderly persons: a systematic review and meta-analysis.
Arnold P, Bautmans I
Exp Gerontol 2014 Oct;58:58-68. Epub 2014 Jul 23 doi: 10.1016/j.exger.2014.07.012. PMID: 25064039

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