U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Onychogryposis of toenails

MedGen UID:
870241
Concept ID:
C4024679
Anatomical Abnormality
Synonym: Overgrowth and curving of toenails
 
HPO: HP:0008401

Definition

Thickened toenails. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOnychogryposis of toenails

Conditions with this feature

Epidermolysis bullosa simplex, Ogna type
MedGen UID:
98488
Concept ID:
C0432317
Disease or Syndrome
Epidermolysis bullosa with pyloric atresia (EB-PA) is characterized by fragility of the skin and mucous membranes, manifested by blistering with little or no trauma; congenital pyloric atresia; and ureteral and renal anomalies (dysplastic/multicystic kidney, hydronephrosis/hydroureter, ureterocele, duplicated renal collecting system, absent bladder). The course of EB-PA is usually severe and often lethal in the neonatal period. Most affected children succumb as neonates; those who survive may have severe blistering with formation of granulation tissue on the skin around the mouth, nose, fingers, and toes, and internally around the trachea. However, some affected individuals have little or no blistering later in life. Additional features shared by EB-PA and the other major forms of EB include congenital localized absence of skin (aplasia cutis congenita) affecting the extremities and/or head, milia, nail dystrophy, scarring alopecia, hypotrichosis, contractures, and dilated cardiomyopathy.
Ectodermal dysplasia with intellectual disability and syndactyly
MedGen UID:
322135
Concept ID:
C1833169
Disease or Syndrome
Pachyonychia congenita 3
MedGen UID:
811523
Concept ID:
C3714948
Disease or Syndrome
Pachyonychia congenita (PC) is characterized by hypertrophic nail dystrophy, painful palmoplantar keratoderma and blistering, oral leukokeratosis, pilosebaceous cysts (including steatocystoma and vellus hair cysts), palmoplantar hyperhydrosis, and follicular keratoses on the trunk and extremities.
Epidermolysis bullosa simplex 6, generalized, with scarring and hair loss
MedGen UID:
934598
Concept ID:
C4310631
Disease or Syndrome
Epidermolysis bullosa simplex (EBS) is characterized by fragility of the skin (and mucosal epithelia in some instances) that results in non-scarring blisters and erosions caused by minor mechanical trauma. EBS is distinguished from other types of epidermolysis bullosa (EB) or non-EB skin fragility syndromes by the location of the blistering in relation to the dermal-epidermal junction. In EBS, blistering occurs within basal keratinocytes. The severity of blistering ranges from limited to hands and feet to widespread involvement. Additional features can include hyperkeratosis of the palms and soles (keratoderma), nail dystrophy, milia, and hyper- and/or hypopigmentation. Rare EBS subtypes have been associated with additional clinical features including pyloric atresia, muscular dystrophy, cardiomyopathy, and/or nephropathy.

Professional guidelines

PubMed

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Prasasya R, Grotheer KV, Siracusa LD, Bartolomei MS
Hum Mol Genet 2020 Sep 30;29(R1):R107-R116. doi: 10.1093/hmg/ddaa133. PMID: 32592473Free PMC Article
Halteh P, Scher RK, Lipner SR
Am J Clin Dermatol 2017 Dec;18(6):763-770. doi: 10.1007/s40257-017-0289-6. PMID: 28488241

Recent clinical studies

Etiology

Gao X, Dai P, Yuan YY
Hum Genet 2022 Apr;141(3-4):821-838. Epub 2021 Jul 7 doi: 10.1007/s00439-021-02310-2. PMID: 34232384
Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Bloom A, Blanken B, Schlakman B, Arena T, Mironov Z, Vlahovic TC
Adv Skin Wound Care 2020 Jan;33(1):20-26. doi: 10.1097/01.ASW.0000613536.27194.3c. PMID: 31856029
Logan IT, Logan RA
Clin Dermatol 2019 Sep-Oct;37(5):580-590. Epub 2019 Jul 20 doi: 10.1016/j.clindermatol.2019.07.019. PMID: 31896411
Caprioli R, Bilotti MA
Clin Podiatr Med Surg 1989 Apr;6(2):431-51. PMID: 2650852

Diagnosis

Iorizzo M, Starace M, Pasch MC
Am J Clin Dermatol 2022 Mar;23(2):177-193. Epub 2022 Feb 2 doi: 10.1007/s40257-022-00671-6. PMID: 35112320Free PMC Article
Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Tosun S, Tosun B
J Am Podiatr Med Assoc 2020 Jul 1;110(4) doi: 10.7547/18-155. PMID: 33021642
Haneke E
Clin Dermatol 2013 Sep-Oct;31(5):516-25. doi: 10.1016/j.clindermatol.2013.06.012. PMID: 24079580
Martin B
Actas Dermosifiliogr 2013 Sep;104(7):564-78. Epub 2013 Jul 17 doi: 10.1016/j.adengl.2013.06.001. PMID: 23871460

Therapy

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Chelidze K, Lipner SR
Int J Dermatol 2018 Jul;57(7):776-783. Epub 2018 Jan 10 doi: 10.1111/ijd.13866. PMID: 29318582
Halteh P, Scher RK, Lipner SR
Am J Clin Dermatol 2017 Dec;18(6):763-770. doi: 10.1007/s40257-017-0289-6. PMID: 28488241
Abbasi NR, Wang N
Dermatol Online J 2008 Oct 15;14(10):18. PMID: 19061617
Lembach L
Clin Podiatr Med Surg 2004 Oct;21(4):641-50. doi: 10.1016/j.cpm.2004.05.014. PMID: 15450903

Prognosis

Bloom A, Blanken B, Schlakman B, Arena T, Mironov Z, Vlahovic TC
Adv Skin Wound Care 2020 Jan;33(1):20-26. doi: 10.1097/01.ASW.0000613536.27194.3c. PMID: 31856029
Sehgal VN, Chatterjee K, Malhotra S
Skinmed 2018;16(2):119. Epub 2018 Apr 1 PMID: 29911530
Chelidze K, Lipner SR
Int J Dermatol 2018 Jul;57(7):776-783. Epub 2018 Jan 10 doi: 10.1111/ijd.13866. PMID: 29318582
Field J
J Hand Surg Eur Vol 2013 Jul;38(6):616-26. Epub 2013 Jan 22 doi: 10.1177/1753193412471021. PMID: 23340755
Kapusta L, Brunner HG, Hamel BC
Eur J Pediatr 1992 Nov;151(11):837-41. doi: 10.1007/BF01957936. PMID: 1468459

Clinical prediction guides

Gao FJ, Hu FY, Xu P, Qi YH, Li JK, Zhang YJ, Chen F, Chang Q, Song F, Shen SM, Xu GZ, Wu JH
Orphanet J Rare Dis 2019 Dec 12;14(1):290. doi: 10.1186/s13023-019-1243-x. PMID: 31831025Free PMC Article
Markatos K, Mavrogenis AF, Karamanou M, Androutsos G
Eur J Orthop Surg Traumatol 2018 Dec;28(8):1569-1572. Epub 2018 May 24 doi: 10.1007/s00590-018-2233-8. PMID: 29797092
Keeling B, Antia C, Steadmon M, Wesson S, Williams C
Dermatol Online J 2014 Sep 16;20(9) PMID: 25244172
Baran R
Clin Dermatol 2011 Jan-Feb;29(1):54-60. doi: 10.1016/j.clindermatol.2010.07.008. PMID: 21146733
Kapusta L, Brunner HG, Hamel BC
Eur J Pediatr 1992 Nov;151(11):837-41. doi: 10.1007/BF01957936. PMID: 1468459

Recent systematic reviews

Kim BR, Yu DA, Lee SR, Lim SS, Mun JH
Acta Derm Venereol 2023 Oct 30;103:adv18251. doi: 10.2340/actadv.v103.18251. PMID: 37902467Free PMC Article
Exley V, Jones K, O'Carroll G, Watson J, Backhouse M
J Foot Ankle Res 2023 Sep 6;16(1):55. doi: 10.1186/s13047-023-00655-7. PMID: 37674170Free PMC Article
Exley V, Jones K, O'Carroll G, Watson J, Backhouse M
J Foot Ankle Res 2023 Jun 10;16(1):35. doi: 10.1186/s13047-023-00631-1. PMID: 37301845Free PMC Article
Tatiane A, Slape D, Lawless R, Frew JW
Clin Exp Dermatol 2019 Aug;44(6):606-612. Epub 2019 May 10 doi: 10.1111/ced.13980. PMID: 31074523
Valdés L, Huggins JT, Gude F, Ferreiro L, Alvarez-Dobaño JM, Golpe A, Toubes ME, González-Barcala FJ, José ES, Sahn SA
Respirology 2014 Oct;19(7):985-92. Epub 2014 Aug 14 doi: 10.1111/resp.12357. PMID: 25123563

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...