U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal hypoproteinemia

MedGen UID:
870253
•Concept ID:
C4024691
•
Disease or Syndrome
HPO: HP:0008360

Definition

A neonatal decreased concentration of proteins in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal hypoproteinemia

Conditions with this feature

Primary intestinal lymphangiectasia
MedGen UID:
444009
•Concept ID:
C2931241
•
Disease or Syndrome
A rare intestinal disease characterized by dilated intestinal lacteals which cause lymph leakage into the small bowel lumen. Clinical manifestations include edema related to hypoalbuminemia (protein-losing gastro-enteropathy), asthenia, moderate diarrhea, lymphedema, serous effusion and failure to thrive in children.
See: Condition Record
Primary intestinal lymphangiectasia

Professional guidelines

PubMed

Hypoproteinemia as a parameter of poor perinatal/neonatal outcomes in women with preeclampsia diagnosed as hypertension plus proteinuria.
Morikawa M, Mayama M, Saito Y, Akabane-Nakagawa K, Umazume T, Chiba K, Kawaguchi S, Cho K, Watari H
Pregnancy Hypertens 2020 Jul;21:111-117. Epub 2020 May 29 doi: 10.1016/j.preghy.2020.05.012. PMID: 32492636
Prevention of Rh isoimmunization and treatment of the compromised fetus.
Grannum PA, Copel JA
Semin Perinatol 1988 Oct;12(4):324-35. PMID: 3146812
Effects and treatment of malabsorption in childhood.
Lloyd JK
Proc Nutr Soc 1972 May;31(1):61-6. PMID: 4625913

Recent clinical studies

Etiology

The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood.
Liu H, Pu Y, Ai S, Wang X, He S, Wang K, Dang Y
Biol Trace Elem Res 2022 Sep;200(9):3965-3974. Epub 2022 Jan 7 doi: 10.1007/s12011-021-02988-5. PMID: 34993909
Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.
Duan S, Zhang X, Jiang X, Ou W, Fu M, Chen K, Xie X, Xiao W, Zheng L, Ma S, Li J
Ann Med 2021 Dec;53(1):900-907. doi: 10.1080/07853890.2021.1938661. PMID: 34121552Free PMC Article
Hyponatremia secondary to severe atopic dermatitis in early infancy.
Adachi M, Takamasu T, Inuo C
Pediatr Int 2019 Jun;61(6):544-550. Epub 2019 Jun 18 doi: 10.1111/ped.13865. PMID: 30985043
Uses and misuses of albumin during resuscitation and in the neonatal intensive care unit.
Shalish W, Olivier F, Aly H, Sant'Anna G
Semin Fetal Neonatal Med 2017 Oct;22(5):328-335. Epub 2017 Jul 22 doi: 10.1016/j.siny.2017.07.009. PMID: 28739260
The enigma of low bilirubin kernicterus in premature infants: why does it still occur, and is it preventable?
Watchko JF, Maisels MJ
Semin Perinatol 2014 Nov;38(7):397-406. Epub 2014 Sep 27 doi: 10.1053/j.semperi.2014.08.002. PMID: 25267279

Diagnosis

Use of Albumin in the NICU: An Evidence-based Review.
Rustogi D, Yusuf K
Neoreviews 2022 Sep 1;23(9):e625-e634. doi: 10.1542/neo.23-9-e625. PMID: 36047753
Hypocalcemia in the critically ill patient.
Kelly A, Levine MA
J Intensive Care Med 2013 May-Jun;28(3):166-77. Epub 2011 Aug 12 doi: 10.1177/0885066611411543. PMID: 21841146
Clinical diagnosis and treatment of acute fatty liver of pregnancy: a literature review and 11 new cases.
Wei Q, Zhang L, Liu X
J Obstet Gynaecol Res 2010 Aug;36(4):751-6. doi: 10.1111/j.1447-0756.2010.01242.x. PMID: 20666940
Intestinal enterokinase deficiency.
Follett GF, Macdonald TH
Acta Paediatr Scand 1976 Sep;65(5):653-5. doi: 10.1111/j.1651-2227.1976.tb04948.x. PMID: 961414
Hypolipoproteinaemia.
Lloyd JK
J Clin Pathol Suppl (Assoc Clin Pathol) 1973;5:53-8. doi: 10.1136/jcp.s1-5.1.53. PMID: 4517658Free PMC Article

Therapy

Uses and misuses of albumin during resuscitation and in the neonatal intensive care unit.
Shalish W, Olivier F, Aly H, Sant'Anna G
Semin Fetal Neonatal Med 2017 Oct;22(5):328-335. Epub 2017 Jul 22 doi: 10.1016/j.siny.2017.07.009. PMID: 28739260
The effect of Ramadan fasting and maternal hypoalbuminaemia on neonatal anthropometric parameters and placental weight.
Sakar MN, Balsak D, Verit FF, Zebitay AG, Buyuk A, Akay E, Turfan M, Demir S, Yayla M
J Obstet Gynaecol 2016 May;36(4):483-6. Epub 2015 Oct 14 doi: 10.3109/01443615.2015.1086989. PMID: 26467047
Hypocalcemia in the critically ill patient.
Kelly A, Levine MA
J Intensive Care Med 2013 May-Jun;28(3):166-77. Epub 2011 Aug 12 doi: 10.1177/0885066611411543. PMID: 21841146
The albumin controversy.
Uhing MR
Clin Perinatol 2004 Sep;31(3):475-88. doi: 10.1016/j.clp.2004.03.018. PMID: 15325533
Albumin infusion for low serum albumin in preterm newborn infants.
Jardine LA, Jenkins-Manning S, Davies MW
Cochrane Database Syst Rev 2004;(3):CD004208. doi: 10.1002/14651858.CD004208.pub2. PMID: 15266522

Prognosis

Use of Albumin in the NICU: An Evidence-based Review.
Rustogi D, Yusuf K
Neoreviews 2022 Sep 1;23(9):e625-e634. doi: 10.1542/neo.23-9-e625. PMID: 36047753
The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood.
Liu H, Pu Y, Ai S, Wang X, He S, Wang K, Dang Y
Biol Trace Elem Res 2022 Sep;200(9):3965-3974. Epub 2022 Jan 7 doi: 10.1007/s12011-021-02988-5. PMID: 34993909
Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.
Duan S, Zhang X, Jiang X, Ou W, Fu M, Chen K, Xie X, Xiao W, Zheng L, Ma S, Li J
Ann Med 2021 Dec;53(1):900-907. doi: 10.1080/07853890.2021.1938661. PMID: 34121552Free PMC Article
Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit.
Iacobelli S, Bonsante F, Lacoutière C, Ferdynus C, Cottenet J, Binquet C, Quantin C, Gouyon JB
J Perinatol 2012 Jul;32(7):520-4. Epub 2011 Sep 29 doi: 10.1038/jp.2011.137. PMID: 21960129
Idiopathic neonatal iron-storage disease.
Barnard JA 3rd, Manci E
Gastroenterology 1991 Nov;101(5):1420-7. doi: 10.1016/0016-5085(91)90097-5. PMID: 1936813

Clinical prediction guides

Use of Albumin in the NICU: An Evidence-based Review.
Rustogi D, Yusuf K
Neoreviews 2022 Sep 1;23(9):e625-e634. doi: 10.1542/neo.23-9-e625. PMID: 36047753
The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood.
Liu H, Pu Y, Ai S, Wang X, He S, Wang K, Dang Y
Biol Trace Elem Res 2022 Sep;200(9):3965-3974. Epub 2022 Jan 7 doi: 10.1007/s12011-021-02988-5. PMID: 34993909
Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.
Duan S, Zhang X, Jiang X, Ou W, Fu M, Chen K, Xie X, Xiao W, Zheng L, Ma S, Li J
Ann Med 2021 Dec;53(1):900-907. doi: 10.1080/07853890.2021.1938661. PMID: 34121552Free PMC Article
Hyponatremia secondary to severe atopic dermatitis in early infancy.
Adachi M, Takamasu T, Inuo C
Pediatr Int 2019 Jun;61(6):544-550. Epub 2019 Jun 18 doi: 10.1111/ped.13865. PMID: 30985043
Hypoproteinemia on the first day of life and adverse outcome in very preterm infants admitted to the neonatal intensive care unit.
Iacobelli S, Bonsante F, Lacoutière C, Ferdynus C, Cottenet J, Binquet C, Quantin C, Gouyon JB
J Perinatol 2012 Jul;32(7):520-4. Epub 2011 Sep 29 doi: 10.1038/jp.2011.137. PMID: 21960129

Recent systematic reviews

Albumin infusion for low serum albumin in preterm newborn infants.
Jardine LA, Jenkins-Manning S, Davies MW
Cochrane Database Syst Rev 2004;(3):CD004208. doi: 10.1002/14651858.CD004208.pub2. PMID: 15266522

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...