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Impaired platelet adhesion

MedGen UID:
870256
Concept ID:
C4024694
Finding
Synonym: Impaired thrombocytes adhesion
 
HPO: HP:0008352

Definition

An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired platelet adhesion

Conditions with this feature

Athrombia, essential
MedGen UID:
349197
Concept ID:
C1859595
Disease or Syndrome

Professional guidelines

PubMed

Gemmati D, Vigliano M, Burini F, Mari R, El Mohsein HH, Parmeggiani F, Serino ML
Curr Pharm Des 2016;22(11):1449-59. doi: 10.2174/1381612822666151210122954. PMID: 26654441
Violi F, Pignatelli P
Thromb Haemost 2014 May 5;111(5):817-23. Epub 2014 Jan 9 doi: 10.1160/TH13-10-0818. PMID: 24402688
White GC 2nd
Semin Hematol 2006 Jan;43(1 Suppl 1):S37-41. doi: 10.1053/j.seminhematol.2005.11.011. PMID: 16427384

Recent clinical studies

Etiology

Marini I, Zlamal J, Faul C, Holzer U, Hammer S, Pelzl L, Bethge W, Althaus K, Bakchoul T
Haematologica 2021 Jan 1;106(1):196-207. doi: 10.3324/haematol.2019.236117. [Epub ahead of print] PMID: 31857361Free PMC Article
Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article
Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484
Spectre G, Roth B, Ronen G, Rosengarten D, Elstein D, Zimran A, Varon D, Revel-Vilk S
Br J Haematol 2011 May;153(3):372-8. Epub 2011 Mar 9 doi: 10.1111/j.1365-2141.2011.08613.x. PMID: 21401572
Castillo R, Lozano T, Escolar G, Revert L, López J, Ordinas A
Blood 1986 Aug;68(2):337-42. PMID: 3730605

Diagnosis

Zhou XJ, Vaziri ND
Nephrol Dial Transplant 2002 Jun;17(6):992-7. doi: 10.1093/ndt/17.6.992. PMID: 12032187

Therapy

Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article
Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484
Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ
Blood 2013 Oct 10;122(15):2732-42. Epub 2013 Aug 7 doi: 10.1182/blood-2013-06-510461. PMID: 23926302Free PMC Article
Spectre G, Roth B, Ronen G, Rosengarten D, Elstein D, Zimran A, Varon D, Revel-Vilk S
Br J Haematol 2011 May;153(3):372-8. Epub 2011 Mar 9 doi: 10.1111/j.1365-2141.2011.08613.x. PMID: 21401572
Castillo R, Lozano T, Escolar G, Revert L, López J, Ordinas A
Blood 1986 Aug;68(2):337-42. PMID: 3730605

Prognosis

Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article

Clinical prediction guides

Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484
Roussi J, Turecek PL, André P, Bonneau M, Pignaud G, Bal dit Sollier C, Schlokat U, Dorner F, Schwarz HP, Drouet L
Blood Coagul Fibrinolysis 1998 Jun;9(4):361-72. doi: 10.1097/00001721-199806000-00009. PMID: 9690808
Weiss HJ, Turitto VT, Baumgartner HR
Blood 1986 Feb;67(2):322-30. PMID: 2935207

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