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Abnormal light-adapted electroretinogram

MedGen UID:
870271
•Concept ID:
C4024712
•
Finding
Synonym: Abnormal cone-mediated electroretinogram
 
HPO: HP:0008275

Conditions with this feature

Blue color blindness
MedGen UID:
57827
•Concept ID:
C0155017
•
Disease or Syndrome
Tritanopia is an autosomal dominant disorder of human vision characterized by a selective deficiency of blue spectral sensitivity (Weitz et al., 1992).
See: Condition Record
Blue color blindness

Professional guidelines

PubMed

Selective cone dystrophy with protan genotype.
Kellner U, Sadowski B, Zrenner E, Foerster MH
Invest Ophthalmol Vis Sci 1995 Nov;36(12):2381-7. PMID: 7591627
Tobacco amblyopia: the effect of treatment on the electroretinogram.
Leighton DA, Bhargava SK, Shail G
Doc Ophthalmol 1979 Mar 15;46(2):325-31. doi: 10.1007/BF00142622. PMID: 477485

Recent clinical studies

Etiology

Analysis of Retinal Structure and Electrophysiological Function in Visual Snow Syndrome: An Exploratory Case Series.
Zaroban NJ, Kedar S, Anderson D, Vuppala AD
J Neuroophthalmol 2023 Jun 1;43(2):227-231. Epub 2022 Dec 12 doi: 10.1097/WNO.0000000000001757. PMID: 36503963
Electroretinogram abnormalities in FKRP-related limb-girdle muscular dystrophy (LGMDR9).
Hagedorn JL, Dunn TM, Bhattarai S, Stephan C, Mathews KD, Pfeifer W, Drack AV
Doc Ophthalmol 2023 Feb;146(1):7-16. Epub 2022 Nov 18 doi: 10.1007/s10633-022-09909-4. PMID: 36399172Free PMC Article
Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders.
Chang YH, Kang EY, Liu PK, Levi SR, Wang HH, Tseng YJ, Seo GH, Lee H, Yeh LK, Chen KJ, Wu WC, Lai CC, Liu L, Wang NK
Invest Ophthalmol Vis Sci 2022 May 2;63(5):5. doi: 10.1167/iovs.63.5.5. PMID: 35506936Free PMC Article
Dark-adapted threshold and electroretinogram for diagnosis of Usher syndrome.
Ambrosio L, Hansen RM, Moskowitz A, Oza A, Barrett D, Manganella J, Medina G, Kawai K, Fulton AB, Kenna M
Doc Ophthalmol 2021 Aug;143(1):39-51. Epub 2021 Jan 28 doi: 10.1007/s10633-021-09818-y. PMID: 33511521
Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography.
Yuan W, Zhou C, Cao Q, Du Z, Hu R, Wang Y, Kijlstra A, Yang P
Am J Ophthalmol 2018 Jul;191:92-99. Epub 2018 Apr 25 doi: 10.1016/j.ajo.2018.04.013. PMID: 29702075

Diagnosis

Electroretinogram abnormalities in FKRP-related limb-girdle muscular dystrophy (LGMDR9).
Hagedorn JL, Dunn TM, Bhattarai S, Stephan C, Mathews KD, Pfeifer W, Drack AV
Doc Ophthalmol 2023 Feb;146(1):7-16. Epub 2022 Nov 18 doi: 10.1007/s10633-022-09909-4. PMID: 36399172Free PMC Article
Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders.
Chang YH, Kang EY, Liu PK, Levi SR, Wang HH, Tseng YJ, Seo GH, Lee H, Yeh LK, Chen KJ, Wu WC, Lai CC, Liu L, Wang NK
Invest Ophthalmol Vis Sci 2022 May 2;63(5):5. doi: 10.1167/iovs.63.5.5. PMID: 35506936Free PMC Article
Dark-adapted threshold and electroretinogram for diagnosis of Usher syndrome.
Ambrosio L, Hansen RM, Moskowitz A, Oza A, Barrett D, Manganella J, Medina G, Kawai K, Fulton AB, Kenna M
Doc Ophthalmol 2021 Aug;143(1):39-51. Epub 2021 Jan 28 doi: 10.1007/s10633-021-09818-y. PMID: 33511521
Electrophysiological and Pupillometric Abnormalities in PROM1 Cone-Rod Dystrophy.
Park JC, Collison FT, Fishman GA, McAnany JJ
Transl Vis Sci Technol 2020 Aug;9(9):26. Epub 2020 Aug 17 doi: 10.1167/tvst.9.9.26. PMID: 32879782Free PMC Article
Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: applications and methods.
Hood DC, Birch DG
Doc Ophthalmol 1996-1997;92(4):253-67. doi: 10.1007/BF02584080. PMID: 9476593

Therapy

The electroretinogram b-wave amplitude: a differential physiological measure for Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder.
Lee IO, Skuse DH, Constable PA, Marmolejo-Ramos F, Olsen LR, Thompson DA
J Neurodev Disord 2022 May 6;14(1):30. doi: 10.1186/s11689-022-09440-2. PMID: 35524181Free PMC Article
Electrophysiological features and multimodal imaging in ritonavir-related maculopathy.
Faure C, Paques M, Audo I
Doc Ophthalmol 2017 Dec;135(3):241-248. Epub 2017 Sep 12 doi: 10.1007/s10633-017-9612-z. PMID: 28900746
Recurrent episodes of night blindness in a patient with short bowel syndrome.
Renner AB, Dietrich-Ntoukas T, Jägle H
Doc Ophthalmol 2015 Dec;131(3):221-30. Epub 2015 Oct 27 doi: 10.1007/s10633-015-9516-8. PMID: 26507840
Genetics and Disease Expression in the CNGA3 Form of Achromatopsia: Steps on the Path to Gene Therapy.
Zelinger L, Cideciyan AV, Kohl S, Schwartz SB, Rosenmann A, Eli D, Sumaroka A, Roman AJ, Luo X, Brown C, Rosin B, Blumenfeld A, Wissinger B, Jacobson SG, Banin E, Sharon D
Ophthalmology 2015 May;122(5):997-1007. Epub 2015 Jan 21 doi: 10.1016/j.ophtha.2014.11.025. PMID: 25616768
Multifocal ERG in chloroquine retinopathy: regional variance of retinal dysfunction.
Kellner U, Kraus H, Foerster MH
Graefes Arch Clin Exp Ophthalmol 2000 Jan;238(1):94-7. doi: 10.1007/s004170050016. PMID: 10664060

Prognosis

Retinal Function in Advanced Multiple Sclerosis.
Hanson JVM, Single S, Eberle RB, Kana V, Ineichen BV, Gerth-Kahlert C
Invest Ophthalmol Vis Sci 2024 Nov 4;65(13):2. doi: 10.1167/iovs.65.13.2. PMID: 39495184Free PMC Article
Luminance Thresholds and Their Correlation With Retinal Structure in X-Linked Retinoschisis.
McAnany JJ, Park JC, Fishman GA, Hyde RA
Invest Ophthalmol Vis Sci 2021 Oct 4;62(13):25. doi: 10.1167/iovs.62.13.25. PMID: 34705026Free PMC Article
Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography.
Yuan W, Zhou C, Cao Q, Du Z, Hu R, Wang Y, Kijlstra A, Yang P
Am J Ophthalmol 2018 Jul;191:92-99. Epub 2018 Apr 25 doi: 10.1016/j.ajo.2018.04.013. PMID: 29702075
Two types of acute zonal occult outer retinopathy differentiated by dark- and light-adapted perimetry.
Kuniyoshi K, Sakuramoto H, Nakao Y, Matsumoto C, Shimomura Y
Jpn J Ophthalmol 2014 Mar;58(2):177-87. Epub 2013 Dec 26 doi: 10.1007/s10384-013-0297-x. PMID: 24368499
Localization of nyctalopin in the mammalian retina.
Morgans CW, Ren G, Akileswaran L
Eur J Neurosci 2006 Mar;23(5):1163-71. doi: 10.1111/j.1460-9568.2006.04647.x. PMID: 16553780

Clinical prediction guides

Electroretinographic abnormalities in Alport syndrome with a novel COL4A5 truncated variant (p.Try20GlyfsTer19).
Mizobuchi K, Hayashi T, Ohira R, Nakano T
Doc Ophthalmol 2023 Jun;146(3):281-291. Epub 2023 May 10 doi: 10.1007/s10633-023-09935-w. PMID: 37162688
Analysis of Retinal Structure and Electrophysiological Function in Visual Snow Syndrome: An Exploratory Case Series.
Zaroban NJ, Kedar S, Anderson D, Vuppala AD
J Neuroophthalmol 2023 Jun 1;43(2):227-231. Epub 2022 Dec 12 doi: 10.1097/WNO.0000000000001757. PMID: 36503963
Electroretinography reveals retinal dysfunction in Parkinson's disease despite normal high-resolution optical coherence tomography findings.
Mello LGM, Paraguay IBB, Andrade TS, Rocha AADN, Barbosa ER, Oyamada MK, Monteiro MLR
Parkinsonism Relat Disord 2022 Aug;101:90-95. Epub 2022 Jun 28 doi: 10.1016/j.parkreldis.2022.06.018. PMID: 35810523
Luminance Thresholds and Their Correlation With Retinal Structure in X-Linked Retinoschisis.
McAnany JJ, Park JC, Fishman GA, Hyde RA
Invest Ophthalmol Vis Sci 2021 Oct 4;62(13):25. doi: 10.1167/iovs.62.13.25. PMID: 34705026Free PMC Article
Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia.
Moghimi P, Torres Jimenez N, McLoon LK, Netoff TI, Lee MS, MacDonald A 3rd, Miller RF
Schizophr Res 2020 May;219:34-46. Epub 2019 Oct 12 doi: 10.1016/j.schres.2019.09.005. PMID: 31615740Free PMC Article

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