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Decreased helper T cell proportion

MedGen UID:
870281
Concept ID:
C4024723
Finding
Synonym: Reduced circulating T-helper cells
 
HPO: HP:0008165

Definition

Reduced proportion of helper T cells relative to the total number of T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased helper T cell proportion

Conditions with this feature

T-cell immunodeficiency, congenital alopecia, and nail dystrophy
MedGen UID:
355713
Concept ID:
C1866426
Disease or Syndrome
T-cell immunodeficiency, congenital alopecia, and nail dystrophy (TIDAND) is an autosomal recessive primary immunodeficiency characterized by congenital thymic aplasia and severe T-cell immunodeficiency apparent at birth or soon thereafter. Affected individuals tend to have recurrent infections, oral candidiasis, and failure to thrive. Immunologic investigations show decreased numbers of T cells with poor proliferative response to phytohemagglutinin (PHA) and variable hypogammaglobulinemia. The phenotype is consistent with a T-/B+/NK+ form of severe combined immunodeficiency (SCID; see, e.g., 102700). Patients with FOXN1 mutations do not respond well to hematopoietic stem cell transplantation, as it is not curative; thymic transplantation offers a potential cure (Chou et al., 2014).

Professional guidelines

PubMed

Zhao J, Chen Y, Li L, Yin H, Song S, Wang Y, Feng X, Fan X, Gao C, Gao L, Zhan Y, Zhao M, Li X, Lu Q
Int J Biol Sci 2024;20(6):2168-2186. Epub 2024 Mar 25 doi: 10.7150/ijbs.92514. PMID: 38617532Free PMC Article
Maeda S, Hashimoto H, Maeda T, Tamechika SY, Isogai S, Naniwa T, Niimi A
Lupus Sci Med 2023 Oct;10(2) doi: 10.1136/lupus-2023-000976. PMID: 37802602Free PMC Article
Du M, Li Y, Gu H, Gao M, Xu H, Zhong W, Liu X, Zhong X
Technol Health Care 2023;31(S1):97-109. doi: 10.3233/THC-236010. PMID: 37038785Free PMC Article

Recent clinical studies

Etiology

Ma X, Deng G, Tian N, Wang H, Zhao H, Kuai L, Luo Y, Gao C, Ding X, Li B, Li B
J Ethnopharmacol 2024 May 23;326:117883. Epub 2024 Feb 7 doi: 10.1016/j.jep.2024.117883. PMID: 38331120
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Osborne LM, Gilden J, Kamperman AM, Hoogendijk WJG, Spicer J, Drexhage HA, Bergink V
Brain Behav Immun 2020 Jul;87:397-403. Epub 2020 Jan 8 doi: 10.1016/j.bbi.2020.01.007. PMID: 31926288Free PMC Article
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Xu C, He X, Liu W, Chen Y, Zhou C, Duan Z, Lu Q, Yan X, Zhang Z, Zheng R
Int Immunopharmacol 2017 May;46:9-15. Epub 2017 Feb 27 doi: 10.1016/j.intimp.2017.02.024. PMID: 28246054

Diagnosis

Sun H, Liu J, Feng R, Wang C, Li Y, Wang X
Iran J Immunol 2022 Mar;19(1):2. doi: 10.22034/IJI.2022.90588.2017. PMID: 35293343
Chen Z, Liu Y, Hu S, Zhang M, Shi B, Wang Y
Front Endocrinol (Lausanne) 2021;12:632492. Epub 2021 Apr 12 doi: 10.3389/fendo.2021.632492. PMID: 33912135Free PMC Article
Kudryavtsev I, Serebriakova M, Starshinova A, Zinchenko Y, Basantsova N, Malkova A, Soprun L, Churilov LP, Toubi E, Yablonskiy P, Shoenfeld Y
Sci Rep 2020 Jan 23;10(1):1059. doi: 10.1038/s41598-020-57741-0. PMID: 31974463Free PMC Article
Xu BY, Meng SJ, Shi SF, Liu LJ, Lv JC, Zhu L, Zhang H
J Nephrol 2020 Jun;33(3):551-560. Epub 2019 Dec 20 doi: 10.1007/s40620-019-00682-3. PMID: 31863364
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article

Therapy

Ma X, Deng G, Tian N, Wang H, Zhao H, Kuai L, Luo Y, Gao C, Ding X, Li B, Li B
J Ethnopharmacol 2024 May 23;326:117883. Epub 2024 Feb 7 doi: 10.1016/j.jep.2024.117883. PMID: 38331120
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Wallin EF
Transplantation 2018 Oct;102(10):1614-1623. doi: 10.1097/TP.0000000000002224. PMID: 29757907Free PMC Article
Xu C, He X, Liu W, Chen Y, Zhou C, Duan Z, Lu Q, Yan X, Zhang Z, Zheng R
Int Immunopharmacol 2017 May;46:9-15. Epub 2017 Feb 27 doi: 10.1016/j.intimp.2017.02.024. PMID: 28246054
Crocker I, Lawson N, Fletcher J
Ann Rheum Dis 2002 Apr;61(4):307-10. doi: 10.1136/ard.61.4.307. PMID: 11874831Free PMC Article

Prognosis

Yang X, Zhang W, Zhao X, Hou W, Wu Y, Feng D, Meng Z, Zhou X
Exp Cell Res 2024 Oct 1;442(2):114259. Epub 2024 Sep 16 doi: 10.1016/j.yexcr.2024.114259. PMID: 39293523
Jia R, Zheng H, Li S, Chen W, Yang Y, Wu H, Chen H, Qin S, Huang S
Phytomedicine 2024 Sep;132:155779. Epub 2024 May 31 doi: 10.1016/j.phymed.2024.155779. PMID: 38876011
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Adami S, Cavani A, Rossi F, Girolomoni G
BioDrugs 2014 Dec;28(6):487-97. doi: 10.1007/s40259-014-0098-x. PMID: 24890029
Andersen AS, Koldjaer Sølling AS, Ovesen T, Rusan M
Int J Cancer 2014 Jun 15;134(12):2755-63. Epub 2013 Aug 29 doi: 10.1002/ijc.28411. PMID: 23913554

Clinical prediction guides

Jin SP, Lee K, Bang YJ, Jeon YH, Jung S, Choi SJ, Lee JS, Kim J, Guttman-Yassky E, Park CG, Kim HJ, Hong S, Lee DH
Allergy 2024 Jun;79(6):1584-1597. doi: 10.1111/all.16121. PMID: 38817208
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C
Inflamm Bowel Dis 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. PMID: 37335900Free PMC Article
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ
Immunity 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. PMID: 30650377Free PMC Article
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L
Cell Mol Immunol 2017 May;14(5):423-431. Epub 2015 Oct 5 doi: 10.1038/cmi.2015.89. PMID: 26435067Free PMC Article

Recent systematic reviews

Huang J, Li X, Zhu Q, Wang M, Xie Z, Zhao T
Front Immunol 2024;15:1425847. Epub 2024 Jul 17 doi: 10.3389/fimmu.2024.1425847. PMID: 39086480Free PMC Article

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