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Posterior retinal neovascularization

MedGen UID:
870359
•Concept ID:
C4024803
•
Anatomical Abnormality
Synonyms: Neovascularization of peripheral and posterior retina; Posterior retinal neovascularisation
 
HPO: HP:0007778

Definition

A type of retinal neovascularization that affects the posterior pole of the retina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior retinal neovascularization

Conditions with this feature

Proliferative vitreoretinopathy
MedGen UID:
66167
•Concept ID:
C0242852
•
Disease or Syndrome
Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
See: Condition Record
Proliferative vitreoretinopathy

Professional guidelines

PubMed

Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease.
Muniyandi A, Hartman GD, Song Y, Mijit M, Kelley MR, Corson TW
J Pharmacol Exp Ther 2023 Jul;386(1):15-25. Epub 2023 May 4 doi: 10.1124/jpet.122.001563. PMID: 37142441Free PMC Article
Laser treatment for choroidal melanoma: Current concepts.
Maheshwari A, Finger PT
Surv Ophthalmol 2023 Mar-Apr;68(2):211-224. Epub 2022 May 27 doi: 10.1016/j.survophthal.2022.05.002. PMID: 35644256
Controlled release technology for anti-angiogenesis treatment of posterior eye diseases: Current status and challenges.
Lau CML, Yu Y, Jahanmir G, Chau Y
Adv Drug Deliv Rev 2018 Feb 15;126:145-161. Epub 2018 Apr 4 doi: 10.1016/j.addr.2018.03.013. PMID: 29625138

Recent clinical studies

Etiology

Pentosan polysulfate maculopathy.
Lindeke-Myers A, Hanif AM, Jain N
Surv Ophthalmol 2022 Jan-Feb;67(1):83-96. Epub 2021 May 14 doi: 10.1016/j.survophthal.2021.05.005. PMID: 34000253
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Dome-shaped macula-Review of literature.
Kumar V, Verma S, Azad SV, Chawla R, Bhayana AA, Surve A, Vohra R, Venkatesh P
Surv Ophthalmol 2021 Jul-Aug;66(4):560-571. Epub 2020 Nov 24 doi: 10.1016/j.survophthal.2020.11.002. PMID: 33245953
Systemic lupus erythematosus and ocular involvement: an overview.
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530

Diagnosis

Pentosan polysulfate maculopathy.
Lindeke-Myers A, Hanif AM, Jain N
Surv Ophthalmol 2022 Jan-Feb;67(1):83-96. Epub 2021 May 14 doi: 10.1016/j.survophthal.2021.05.005. PMID: 34000253
Asymmetric diabetic retinopathy.
Azad R, Sinha S, Nishant P
Indian J Ophthalmol 2021 Nov;69(11):3026-3034. doi: 10.4103/ijo.IJO_1525_21. PMID: 34708738Free PMC Article
Systemic lupus erythematosus and ocular involvement: an overview.
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035
Mechanisms of macular edema: Beyond the surface.
Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F
Prog Retin Eye Res 2018 Mar;63:20-68. Epub 2017 Nov 7 doi: 10.1016/j.preteyeres.2017.10.006. PMID: 29126927
Ocular ischemic syndrome - a systematic review.
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article

Therapy

Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease.
Muniyandi A, Hartman GD, Song Y, Mijit M, Kelley MR, Corson TW
J Pharmacol Exp Ther 2023 Jul;386(1):15-25. Epub 2023 May 4 doi: 10.1124/jpet.122.001563. PMID: 37142441Free PMC Article
Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED.
Garkal A, Bangar P, Rajput A, Pingale P, Dhas N, Sami A, Mathur K, Joshi S, Dhuri S, Parikh D, Mutalik S, Mehta T
J Control Release 2022 Oct;350:538-568. Epub 2022 Sep 2 doi: 10.1016/j.jconrel.2022.08.040. PMID: 36030993
Pentosan polysulfate maculopathy.
Lindeke-Myers A, Hanif AM, Jain N
Surv Ophthalmol 2022 Jan-Feb;67(1):83-96. Epub 2021 May 14 doi: 10.1016/j.survophthal.2021.05.005. PMID: 34000253
Multimodal Imaging in Ocular Toxoplasmosis.
Brandão-de-Resende C, Balasundaram MB, Narain S, Mahendradas P, Vasconcelos-Santos DV
Ocul Immunol Inflamm 2020 Nov 16;28(8):1196-1204. Epub 2020 Mar 11 doi: 10.1080/09273948.2020.1737142. PMID: 32160073
Anti-VEGF for ROP and Pediatric Retinal Diseases.
Wu AL, Wu WC
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):145-151. Epub 2018 Apr 9 doi: 10.22608/APO.201837. PMID: 29633587

Prognosis

Current clinical applications of anterior segment optical coherence tomography angiography: a review.
Wen Y, Jiang D, Tang K, Chen W
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2729-2741. Epub 2023 Mar 2 doi: 10.1007/s00417-023-05997-3. PMID: 36862203
Neovascular Glaucoma: An Update.
Kalogeropoulos D, Moussa G, Sung VC, Pappa C, Kalogeropoulos C
Klin Monbl Augenheilkd 2023 Mar;240(3):305-315. Epub 2022 Nov 27 doi: 10.1055/a-1956-9348. PMID: 36436509
Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED.
Garkal A, Bangar P, Rajput A, Pingale P, Dhas N, Sami A, Mathur K, Joshi S, Dhuri S, Parikh D, Mutalik S, Mehta T
J Control Release 2022 Oct;350:538-568. Epub 2022 Sep 2 doi: 10.1016/j.jconrel.2022.08.040. PMID: 36030993
The choroidal rupture: current concepts and insights.
Lupidi M, Muzi A, Castellucci G, Kalra G, Piccolino FC, Chhablani J, Cagini C
Surv Ophthalmol 2021 Sep-Oct;66(5):761-770. Epub 2021 Feb 2 doi: 10.1016/j.survophthal.2021.01.014. PMID: 33545177
Mechanisms of macular edema: Beyond the surface.
Daruich A, Matet A, Moulin A, Kowalczuk L, Nicolas M, Sellam A, Rothschild PR, Omri S, Gélizé E, Jonet L, Delaunay K, De Kozak Y, Berdugo M, Zhao M, Crisanti P, Behar-Cohen F
Prog Retin Eye Res 2018 Mar;63:20-68. Epub 2017 Nov 7 doi: 10.1016/j.preteyeres.2017.10.006. PMID: 29126927

Clinical prediction guides

Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED.
Garkal A, Bangar P, Rajput A, Pingale P, Dhas N, Sami A, Mathur K, Joshi S, Dhuri S, Parikh D, Mutalik S, Mehta T
J Control Release 2022 Oct;350:538-568. Epub 2022 Sep 2 doi: 10.1016/j.jconrel.2022.08.040. PMID: 36030993
Tilted disc syndrome (TDS): New hypotheses for posterior segment complications and their implications in other retinal diseases.
Cohen SY, Vignal-Clermont C, Trinh L, Ohno-Matsui K
Prog Retin Eye Res 2022 May;88:101020. Epub 2021 Nov 17 doi: 10.1016/j.preteyeres.2021.101020. PMID: 34800679
Asymmetric diabetic retinopathy.
Azad R, Sinha S, Nishant P
Indian J Ophthalmol 2021 Nov;69(11):3026-3034. doi: 10.4103/ijo.IJO_1525_21. PMID: 34708738Free PMC Article
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530
Mechanisms of maculopathy.
Eagle RC Jr
Ophthalmology 1984 Jun;91(6):613-25. doi: 10.1016/s0161-6420(84)34259-2. PMID: 6205340

Recent systematic reviews

The effectiveness and safety of posterior scleral reinforcement with vitrectomy for myopic foveoschisis treatment: a systematic review and meta-analysis.
Cao K, Wang J, Zhang J, Yusufu M, Jin S, Zhu G, He H, Qi Y, Wan XH
Graefes Arch Clin Exp Ophthalmol 2020 Feb;258(2):257-271. Epub 2019 Dec 10 doi: 10.1007/s00417-019-04550-5. PMID: 31823060
Ocular ischemic syndrome - a systematic review.
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article
Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update.
Stanga PE, Lim JI, Hamilton P
Ophthalmology 2003 Jan;110(1):15-21; quiz 22-3. doi: 10.1016/s0161-6420(02)01563-4. PMID: 12511340

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