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Diffuse nuclear cataract

MedGen UID:
870376
•Concept ID:
C4024821
•
Disease or Syndrome
HPO: HP:0007657

Definition

Opacity of the entire lens nucleus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse nuclear cataract

Conditions with this feature

Cataract 30
MedGen UID:
811741
•Concept ID:
C3805411
•
Disease or Syndrome
Mutations in the VIM gene have been found to cause multiple types of congenital cataract, which have been described as congenital, pulverulent, and posterior polar.
See: Condition Record
Cataract 30

Professional guidelines

PubMed

Intravitreal triamcinolone acetonide for treatment of intraocular oedematous and neovascular diseases.
Jonas JB
Acta Ophthalmol Scand 2005 Dec;83(6):645-63. doi: 10.1111/j.1600-0420.2005.00592.x. PMID: 16396641

Recent clinical studies

Etiology

Surgical decisions in the setting of zonulopathy.
Fram NR, McKee Y, Chang DF, Chee SP, Donaldson KE, Crandall DA, Al-Mohtaseb Z, Chen AJ
J Cataract Refract Surg 2023 Feb 1;49(2):221-222. doi: 10.1097/j.jcrs.0000000000001129. PMID: 36700891
Use of fluocinolone acetonide intravitreal implant to manage chronic panuveitis for long-term inflammatory control without interfering with systemic immunity.
Chang PY
Digit J Ophthalmol 2022;28(4):119-125. Epub 2022 Dec 28 doi: 10.5693/djo.02.2022.10.002. PMID: 36660185Free PMC Article
Factors influencing myopic shift in children after intraocular lens implantation.
Valeina S, Heede S, Erts R, Sepetiene S, Skaistkalne E, Radecka L, Vanags J, Laganovska G
Eur J Ophthalmol 2020 Sep;30(5):933-940. Epub 2019 Apr 26 doi: 10.1177/1120672119845228. PMID: 31025587
Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye.
Beebe DC, Shui YB, Siegfried CJ, Holekamp NM, Bai F
Jpn J Ophthalmol 2014 May;58(3):225-31. Epub 2014 Apr 2 doi: 10.1007/s10384-014-0318-4. PMID: 24687817
Clinical photon correlation spectroscopy evaluation of human diabetic lenses.
Bursell SE, Baker RS, Weiss JN, Haughton JF, Rand LI
Exp Eye Res 1989 Aug;49(2):241-58. doi: 10.1016/0014-4835(89)90094-8. PMID: 2767171

Diagnosis

Use of fluocinolone acetonide intravitreal implant to manage chronic panuveitis for long-term inflammatory control without interfering with systemic immunity.
Chang PY
Digit J Ophthalmol 2022;28(4):119-125. Epub 2022 Dec 28 doi: 10.5693/djo.02.2022.10.002. PMID: 36660185Free PMC Article
A homozygous Y443C variant in the RNPC3 is associated with severe syndromic congenital hypopituitarism and diffuse brain atrophy.
Bezen D, Kutlu O, Mouilleron S, Rizzoti K, Dattani M, Guran T, Yeşil G
Am J Med Genet A 2022 Sep;188(9):2701-2706. Epub 2022 Jul 6 doi: 10.1002/ajmg.a.62888. PMID: 35792517
Premature Expression of Pseudoexfoliation Syndrome With Presenile Cataract in a 28-Year-Old Lady.
Kumar PS, Rao A, Senthil S
J Glaucoma 2019 Jul;28(7):e115-e117. doi: 10.1097/IJG.0000000000001219. PMID: 30807439
BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT.
Alasil T, Coady PA, Koudsi S, Mathur M, Materin MA
Retin Cases Brief Rep 2017 Winter;11(1):71-74. doi: 10.1097/ICB.0000000000000292. PMID: 27046327
Quasielastic light scattering study of the living human lens as a function of age.
Thurston GM, Hayden DL, Burrows P, Clark JI, Taret VG, Kandel J, Courogen M, Peetermans JA, Bowen MS, Miller D, Sullivan KM, Storb R, Stern H, Benedek GB
Curr Eye Res 1997 Mar;16(3):197-207. doi: 10.1076/ceyr.16.3.197.15410. PMID: 9088735

Therapy

Analysis of influencing factors of corneal edema after phacoemulsification for diabetic cataract.
Jing Z, Hao J, Sun L, Zhao X, Jia X, Liu Z, Zhang K
Cell Mol Biol (Noisy-le-grand) 2023 Apr 30;69(4):164-171. doi: 10.14715/cmb/2023.69.4.26. PMID: 37329530
Surgical decisions in the setting of zonulopathy.
Fram NR, McKee Y, Chang DF, Chee SP, Donaldson KE, Crandall DA, Al-Mohtaseb Z, Chen AJ
J Cataract Refract Surg 2023 Feb 1;49(2):221-222. doi: 10.1097/j.jcrs.0000000000001129. PMID: 36700891
Deadbolt cataract due to misplanted minishunt.
Ten Hulzen RD, Wagner IV, Aref AA, Provencher LM, Razeghinejad R, Danesh-Meyer HV, Goyal S, De Francesco T, Ahmed IIK
J Cataract Refract Surg 2022 Jul 1;48(7):863. doi: 10.1097/j.jcrs.0000000000000979. PMID: 35749070
Factors influencing myopic shift in children after intraocular lens implantation.
Valeina S, Heede S, Erts R, Sepetiene S, Skaistkalne E, Radecka L, Vanags J, Laganovska G
Eur J Ophthalmol 2020 Sep;30(5):933-940. Epub 2019 Apr 26 doi: 10.1177/1120672119845228. PMID: 31025587
Intravitreal triamcinolone acetonide: a change in a paradigm.
Jonas JB
Ophthalmic Res 2006;38(4):218-45. Epub 2006 Jun 6 doi: 10.1159/000093796. PMID: 16763379

Prognosis

Surgical decisions in the setting of zonulopathy.
Fram NR, McKee Y, Chang DF, Chee SP, Donaldson KE, Crandall DA, Al-Mohtaseb Z, Chen AJ
J Cataract Refract Surg 2023 Feb 1;49(2):221-222. doi: 10.1097/j.jcrs.0000000000001129. PMID: 36700891
Use of fluocinolone acetonide intravitreal implant to manage chronic panuveitis for long-term inflammatory control without interfering with systemic immunity.
Chang PY
Digit J Ophthalmol 2022;28(4):119-125. Epub 2022 Dec 28 doi: 10.5693/djo.02.2022.10.002. PMID: 36660185Free PMC Article
Deadbolt cataract due to misplanted minishunt.
Ten Hulzen RD, Wagner IV, Aref AA, Provencher LM, Razeghinejad R, Danesh-Meyer HV, Goyal S, De Francesco T, Ahmed IIK
J Cataract Refract Surg 2022 Jul 1;48(7):863. doi: 10.1097/j.jcrs.0000000000000979. PMID: 35749070
The influence of cataract types on potential acuity meter results.
Carpel EF, Henderson V
J Cataract Refract Surg 1986 May;12(3):276-7. doi: 10.1016/s0886-3350(86)80008-6. PMID: 3712267

Clinical prediction guides

Immunohistochemical Profiles of LOXL-1, FBN1, TGF-β1, and COX-2 in Pseudoexfoliation Syndrome.
Papadopoulou M, Papadaki H, Zolota V, Gartaganis SP
Curr Eye Res 2017 Jun;42(6):880-889. Epub 2017 Jan 13 doi: 10.1080/02713683.2016.1257726. PMID: 28085506
BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION: A CASE REPORT.
Alasil T, Coady PA, Koudsi S, Mathur M, Materin MA
Retin Cases Brief Rep 2017 Winter;11(1):71-74. doi: 10.1097/ICB.0000000000000292. PMID: 27046327
Presence and distribution of L-kynurenine aminotransferases immunoreactivity in human cataractous lenses.
Rejdak R, Oleszczuk A, Rummelt C, Turski WA, Choragiewicz T, Nowomiejska K, Ksiazek K, Thaler S, Zarnowski T, Okuno E, Grieb P, Zrenner E, Kruse F, Junemann AG
Acta Ophthalmol 2013 Sep;91(6):e450-5. Epub 2013 Apr 17 doi: 10.1111/aos.12138. PMID: 23590420
Sphingolipid distribution changes with age in the human lens.
Deeley JM, Hankin JA, Friedrich MG, Murphy RC, Truscott RJ, Mitchell TW, Blanksby SJ
J Lipid Res 2010 Sep;51(9):2753-60. Epub 2010 Jun 14 doi: 10.1194/jlr.M007716. PMID: 20547889Free PMC Article
Intravitreal triamcinolone acetonide: a change in a paradigm.
Jonas JB
Ophthalmic Res 2006;38(4):218-45. Epub 2006 Jun 6 doi: 10.1159/000093796. PMID: 16763379

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