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Progressive hyperpigmentation

MedGen UID:
870414
Concept ID:
C4024859
Pathologic Function
HPO: HP:0007505

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive hyperpigmentation

Conditions with this feature

Hyperpigmentation with or without hypopigmentation, familial progressive
MedGen UID:
333550
Concept ID:
C1840392
Disease or Syndrome
Familial progressive hyperpigmentation with or without hypopigmentation (FPHH) is characterized by diffuse hyperpigmentation of variable intensity sometimes associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules. These features, which involve the face, neck, trunk, and limbs, are seen at birth or develop early in infancy (summary by Wang et al., 2009 and Amyere et al., 2011). Also see familial progressive hyperpigmentation (FPH1; 614233).

Professional guidelines

PubMed

Perez MI
Cutis 2005 Apr;75(4):217-22. PMID: 15916218

Recent clinical studies

Etiology

Zhang J, Li M, Yao Z
Mol Med Rep 2016 Nov;14(5):4023-4029. Epub 2016 Sep 22 doi: 10.3892/mmr.2016.5760. PMID: 27666661Free PMC Article
Karadag A, Kavala M, Demir F, Turkoğlu Z, Kartal I, Zemheri E
Hum Exp Toxicol 2014 Dec;33(12):1297-301. Epub 2014 Feb 6 doi: 10.1177/0960327113514099. PMID: 24505054
Chernosky ME, Anderson DE, Chang JP, Shaw MW, Romsdahl MM
Arch Dermatol 1971 Jun;103(6):581-91 passim. PMID: 4326548

Diagnosis

Gosch ME, McMichael AJ, Niehaus AG, Sangüeza OP
Am J Dermatopathol 2024 Apr 1;46(4):255-256. doi: 10.1097/DAD.0000000000002671. PMID: 38488349
Pathania YS, Budania A
Pediatr Dermatol 2021 Jul;38(4):e28-e29. doi: 10.1111/pde.14666. PMID: 34448229
Zhang J, Li M, Yao Z
Mol Med Rep 2016 Nov;14(5):4023-4029. Epub 2016 Sep 22 doi: 10.3892/mmr.2016.5760. PMID: 27666661Free PMC Article
Hüffmeier U, Hausser I, Reis A, Rauch A
Am J Med Genet A 2005 Jun 1;135(2):195-9. doi: 10.1002/ajmg.a.30668. PMID: 15852476
Chernosky ME, Anderson DE, Chang JP, Shaw MW, Romsdahl MM
Arch Dermatol 1971 Jun;103(6):581-91 passim. PMID: 4326548

Therapy

Takeichi T, Hsu CK, Yang HS, Chen HY, Wong TW, Tsai WL, Chao SC, Lee JY, Akiyama M, Simpson MA, McGrath JA
Br J Dermatol 2015 Apr;172(4):1111-5. Epub 2015 Feb 27 doi: 10.1111/bjd.13413. PMID: 25234635
Karadag A, Kavala M, Demir F, Turkoğlu Z, Kartal I, Zemheri E
Hum Exp Toxicol 2014 Dec;33(12):1297-301. Epub 2014 Feb 6 doi: 10.1177/0960327113514099. PMID: 24505054
Perez MI
Cutis 2005 Apr;75(4):217-22. PMID: 15916218

Prognosis

Ali N, Maharaj AV, Buonocore F, Achermann JC, Metherell LA
Front Endocrinol (Lausanne) 2022;13:860055. Epub 2022 Mar 28 doi: 10.3389/fendo.2022.860055. PMID: 35418949Free PMC Article
Wang ZQ, Si L, Tang Q, Lin D, Fu Z, Zhang J, Cui B, Zhu Y, Kong X, Deng M, Xia Y, Xu H, Le W, Hu L, Kong X
Am J Hum Genet 2009 May;84(5):672-7. Epub 2009 Apr 16 doi: 10.1016/j.ajhg.2009.03.019. PMID: 19375057Free PMC Article
Stenson S
Ann Ophthalmol 1982 Jun;14(6):580-5. PMID: 7114695

Clinical prediction guides

Vona B, Schwartzbaum DA, Rodriguez AA, Lewis SS, Toosi MB, Radhakrishnan P, Bozan N, Akın R, Doosti M, Manju R, Duman D, Sineni CJ, Nampoothiri S, Karimiani EG, Houlden H, Bademci G, Tekin M, Girisha KM, Maroofian R, Douzgou S
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1606-1611. Epub 2022 May 25 doi: 10.1111/jdv.18207. PMID: 35543077Free PMC Article
Ali N, Maharaj AV, Buonocore F, Achermann JC, Metherell LA
Front Endocrinol (Lausanne) 2022;13:860055. Epub 2022 Mar 28 doi: 10.3389/fendo.2022.860055. PMID: 35418949Free PMC Article
Wang T, Li H, Dong Y, Hu M, She Q, Deng Y
J Cutan Pathol 2017 Nov;44(11):948-950. Epub 2017 Sep 4 doi: 10.1111/cup.13012. PMID: 28749546
Amyere M, Vogt T, Hoo J, Brandrup F, Bygum A, Boon L, Vikkula M
J Invest Dermatol 2011 Jun;131(6):1234-9. Epub 2011 Mar 3 doi: 10.1038/jid.2011.29. PMID: 21368769
Wang ZQ, Si L, Tang Q, Lin D, Fu Z, Zhang J, Cui B, Zhu Y, Kong X, Deng M, Xia Y, Xu H, Le W, Hu L, Kong X
Am J Hum Genet 2009 May;84(5):672-7. Epub 2009 Apr 16 doi: 10.1016/j.ajhg.2009.03.019. PMID: 19375057Free PMC Article

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