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Osteosclerosis of ribs

MedGen UID:
870565
•Concept ID:
C4025013
•
Disease or Syndrome
Synonym: Increased bone density in ribs
 
HPO: HP:0006634

Definition

Osteosclerosis of ribs (increased density related to increased bone mass). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteosclerosis of ribs

Recent clinical studies

Etiology

Long-term follow-up of severe autosomal recessive SP7-related bone disorder.
Gauthier LW, Fontanges E, Chapurlat R, Collet C, Rossi M
Bone 2024 Feb;179:116953. Epub 2023 Oct 31 doi: 10.1016/j.bone.2023.116953. PMID: 37918503
Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl.
Uludağ Alkaya D, Akpınar E, Bilguvar K, Tüysüz B
Am J Med Genet A 2021 Jul;185(7):2271-2277. Epub 2021 Apr 10 doi: 10.1002/ajmg.a.62198. PMID: 33837634
A new familial sclerosing bone dysplasia.
Chouery E, Pangrazio A, Frattini A, Villa A, Van Wesenbeeck L, Piters E, Van Hul W, Coxon FP, Schouten T, Helfrich M, Lefranc G, Mégarbané A
J Bone Miner Res 2010 Mar;25(3):676-80. doi: 10.1359/jbmr.090733. PMID: 20422625
Surgical resection of melorheostosis in the ribs.
Chanda B, Millner RW
Ann Thorac Surg 2007 Apr;83(4):1518-9. doi: 10.1016/j.athoracsur.2006.09.055. PMID: 17383370
Progress of brown tumors in patients with chronic renal insufficiency undergoing dialysis.
Marini M, Vidiri A, Guerrisi R, Campodonico F, Ponzio R
Eur J Radiol 1992 Jan-Feb;14(1):67-71. doi: 10.1016/0720-048x(92)90066-i. PMID: 1563408

Diagnosis

Melorheostosis With Uniform Rib Thickening.
Ariga A, Funauchi Y, Sato S, Kunieda J, Yoshii T
Clin Nucl Med 2024 Jul 1;49(7):662-663. Epub 2024 May 15 doi: 10.1097/RLU.0000000000005268. PMID: 38758532
A case of autosomal dominant osteopetrosis type II with a novel TCIRG1 gene mutation.
Wada K, Harada D, Michigami T, Tachikawa K, Nakano Y, Kashiwagi H, Yamashita S, Sano T, Seino Y
J Pediatr Endocrinol Metab 2013;26(5-6):575-7. doi: 10.1515/jpem-2013-0007. PMID: 23412864
Skeletal dysplasia with unusual visceral manifestations.
Ahuja SR, Karande S, Kulkarni MV
Postgrad Med J 2002 Feb;78(916):99-100, 107. doi: 10.1136/pmj.78.916.99. PMID: 11807194Free PMC Article
Bone imaging as an aid for the diagnosis of osteopoikilosis.
Tong EC, Samii M, Tchang F
Clin Nucl Med 1988 Nov;13(11):816-9. doi: 10.1097/00003072-198811000-00009. PMID: 3233868
Growing bone islands.
Ngan H
Clin Radiol 1972 Apr;23(2):199-201. doi: 10.1016/s0009-9260(72)80096-5. PMID: 5076294

Therapy

Atypical form of melorheostosis improved by pamidronate.
Saadallaoui Ben Hamida K, Ksontini I, Rahali H, Mourali S, Fejraoui N, Bouhaouala H, Charfi MR, Dougui MH
Tunis Med 2009 Mar;87(3):204-6. PMID: 19537015
Solitary hot spots in the ribs on bone scan: value of thin-section reformatted computed tomography to exclude radiography-negative fractures.
Niitsu M, Takeda T
J Comput Assist Tomogr 2003 Jul-Aug;27(4):469-74. doi: 10.1097/00004728-200307000-00002. PMID: 12886126
Congenital erythropoietic porphyria: skeletal manifestations and effect of pamidronate treatment.
Oliveri MB, Mautalen C, Mega M, Rossi E
Bone 1994 Jan-Feb;15(1):101-4. doi: 10.1016/8756-3282(94)90899-0. PMID: 8024843
Marble bone disease in a child.
Chaudhuri JN, Banerjee S, Kashnia BR, Chatterji P, Soni NK
J Laryngol Otol 1986 Aug;100(8):935-8. doi: 10.1017/s0022215100100349. PMID: 3746110
Osteosclerosis in myeloma.
Brown TS, Paterson CR
J Bone Joint Surg Br 1973 Aug;55(3):621-3. PMID: 4729029

Prognosis

Long-term follow-up of severe autosomal recessive SP7-related bone disorder.
Gauthier LW, Fontanges E, Chapurlat R, Collet C, Rossi M
Bone 2024 Feb;179:116953. Epub 2023 Oct 31 doi: 10.1016/j.bone.2023.116953. PMID: 37918503
Case Report: Osteosclerotic metaphyseal dysplasia with optic nerve involvement and progressive osteonecrosis of the jaw due to a novel LRRK1 mutation.
Pieridou C, Sabir A, Lancashire J, Liang Y, McMillan K, Shaw N, Uday S
Front Endocrinol (Lausanne) 2023;14:1258340. Epub 2023 Oct 18 doi: 10.3389/fendo.2023.1258340. PMID: 37920250Free PMC Article
Osteopetrosis: Gene-based nosology and significance Dysosteosclerosis.
Turan S
Bone 2023 Feb;167:116615. Epub 2022 Nov 17 doi: 10.1016/j.bone.2022.116615. PMID: 36402365
Surgical resection of melorheostosis in the ribs.
Chanda B, Millner RW
Ann Thorac Surg 2007 Apr;83(4):1518-9. doi: 10.1016/j.athoracsur.2006.09.055. PMID: 17383370
Progress of brown tumors in patients with chronic renal insufficiency undergoing dialysis.
Marini M, Vidiri A, Guerrisi R, Campodonico F, Ponzio R
Eur J Radiol 1992 Jan-Feb;14(1):67-71. doi: 10.1016/0720-048x(92)90066-i. PMID: 1563408

Clinical prediction guides

Case Report: Osteosclerotic metaphyseal dysplasia with optic nerve involvement and progressive osteonecrosis of the jaw due to a novel LRRK1 mutation.
Pieridou C, Sabir A, Lancashire J, Liang Y, McMillan K, Shaw N, Uday S
Front Endocrinol (Lausanne) 2023;14:1258340. Epub 2023 Oct 18 doi: 10.3389/fendo.2023.1258340. PMID: 37920250Free PMC Article
Osteopetrosis: Gene-based nosology and significance Dysosteosclerosis.
Turan S
Bone 2023 Feb;167:116615. Epub 2022 Nov 17 doi: 10.1016/j.bone.2022.116615. PMID: 36402365
Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl.
Uludağ Alkaya D, Akpınar E, Bilguvar K, Tüysüz B
Am J Med Genet A 2021 Jul;185(7):2271-2277. Epub 2021 Apr 10 doi: 10.1002/ajmg.a.62198. PMID: 33837634
Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review).
Cook FJ, Seagrove-Guffey M, Mumm S, Veis DJ, McAlister WH, Bijanki VN, Wenkert D, Whyte MP
Bone 2021 Apr;145:115839. Epub 2021 Jan 6 doi: 10.1016/j.bone.2021.115839. PMID: 33418099Free PMC Article
Osteosclerotic metaphyseal dysplasia with extensive interstitial pulmonary lesions: a case report and literature review.
Zheng H, Cai J, Wang L, He X
Skeletal Radiol 2015 Oct;44(10):1529-33. Epub 2015 Jun 18 doi: 10.1007/s00256-015-2190-9. PMID: 26084987

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