U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agenesis of mandibular central incisor

MedGen UID:
870605
•Concept ID:
C4025054
•
Anatomical Abnormality
Synonyms: Absence of lower central incisor; Absence of mandibular central incisor; Failure of development of mandibular central incisor; Missing lower central incisor; Missing mandibular central incisor
 
HPO: HP:0006355

Definition

Agenesis of lower secondary incisor or lower primary incisor. [from HPO]

Conditions with this feature

Incisors, lower central, absence of
MedGen UID:
333512
•Concept ID:
C1840225
•
Finding
See: Condition Record
Richieri Costa-Pereira syndrome
MedGen UID:
336581
•Concept ID:
C1849348
•
Disease or Syndrome
Patients with Richieri-Costa-Pereira syndrome display a pattern of anomalies consisting of microstomia, micrognathia, abnormal fusion of the mandible, cleft palate/Robin sequence, absence of lower central incisors, minor ear anomalies, hypoplastic first ray, abnormal tibiae, hypoplastic halluces, and clubfeet. Learning disability is also a common finding (summary by Favaro et al., 2011).
See: Condition Record
Incisors, lower central, absence of
Richieri Costa-Pereira syndrome

Professional guidelines

PubMed

Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570Free PMC Article
Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia.
Goldenberg M, Das P, Messersmith M, Stockton DW, Patel PI, D'Souza RN
J Dent Res 2000 Jul;79(7):1469-75. doi: 10.1177/00220345000790070701. PMID: 11005730
Pattern of agenesis in the primary dentition: a radiographic study of 193 cases.
Daugaard-Jensen J, Nodal M, Kjaer I
Int J Paediatr Dent 1997 Mar;7(1):3-7. doi: 10.1111/j.1365-263x.1997.tb00265.x. PMID: 9524465

Recent clinical studies

Etiology

Three-dimensional digital evaluation of tooth symmetry and volume in patients with missing and peg-shaped maxillary lateral incisors.
Aras I, Canigur Bavbek N, Kaya B, Aras A
Am J Orthod Dentofacial Orthop 2022 Aug;162(2):e82-e95. Epub 2022 Jun 23 doi: 10.1016/j.ajodo.2022.05.005. PMID: 35752511
The prevalence of incisor hypomineralisation and its relationship with the prevalence of molar incisor hypomineralisation.
Balmer R, Toumba KJ, Munyombwe T, Godson J, Duggal MS
Eur Arch Paediatr Dent 2015 Jun;16(3):265-9. Epub 2015 Apr 18 doi: 10.1007/s40368-014-0171-7. PMID: 25894246
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Facial talon cusps.
McNamara T, Haeussler AM, Keane J
Int J Paediatr Dent 1997 Dec;7(4):259-62. doi: 10.1046/j.1365-263x.1997.00052.x. PMID: 9482033
Natal teeth.
Leung AK
Am J Dis Child 1986 Mar;140(3):249-51. doi: 10.1001/archpedi.1986.02140170075033. PMID: 3946356

Diagnosis

Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
The prevalence of incisor hypomineralisation and its relationship with the prevalence of molar incisor hypomineralisation.
Balmer R, Toumba KJ, Munyombwe T, Godson J, Duggal MS
Eur Arch Paediatr Dent 2015 Jun;16(3):265-9. Epub 2015 Apr 18 doi: 10.1007/s40368-014-0171-7. PMID: 25894246
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Facial talon cusps.
McNamara T, Haeussler AM, Keane J
Int J Paediatr Dent 1997 Dec;7(4):259-62. doi: 10.1046/j.1365-263x.1997.00052.x. PMID: 9482033
Williams syndrome--oral presentation of 45 cases.
Hertzberg J, Nakisbendi L, Needleman HL, Pober B
Pediatr Dent 1994 Jul-Aug;16(4):262-7. PMID: 7937257

Therapy

Investigation of maxillofacial morphology and oral characteristics with Turner syndrome and early mixed dentition.
Ahiko N, Baba Y, Tsuji M, Horikawa R, Moriyama K
Congenit Anom (Kyoto) 2019 Jan;59(1):11-17. Epub 2018 May 16 doi: 10.1111/cga.12284. PMID: 29691907
Cephalometric Findings in Nine Individuals With Richieri-Costa-Pereira Syndrome.
Pinto RO, Peixoto AP, Pinto ADS, Richieri-Costa A, Zechi-Ceide RM, Ozawa TO, Dalben GDS
J Craniofac Surg 2018 Sep;29(6):1596-1600. doi: 10.1097/SCS.0000000000004588. PMID: 29863549
Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.
Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766Free PMC Article
Evaluation of treatment modality for skeletal Class III malocclusion with labioversed upper incisors and/or protrusive maxilla: surgical movement and stability of rotational maxillary setback procedure.
Baek SH, Kim K, Choi JY
J Craniofac Surg 2009 Nov;20(6):2049-54. doi: 10.1097/SCS.0b013e3181be87ba. PMID: 19881370
Prevalence of dental caries and enamel defects in children living in areas with different water fluoride concentrations.
Angelillo IF, Romano F, Fortunato L, Montanaro D
Community Dent Health 1990 Sep;7(3):229-36. PMID: 2076499

Prognosis

Interceptive orthodontic management of mandibular lateral incisor-canine transposition using simplified and efficient biomechanical approach: A case report.
Singh H, Mittal T, Sharma P, Kapoor P, Maurya RK, Rastogi S
Int Orthod 2022 Dec;20(4):100690. Epub 2022 Sep 16 doi: 10.1016/j.ortho.2022.100690. PMID: 36123290
Treatment of type III dens invaginatus in bilateral immature mandibular central incisors: a case report.
Zhang J, Wang Y, Xu L, Wu Z, Tu Y
BMC Oral Health 2022 Feb 4;22(1):28. doi: 10.1186/s12903-022-02059-8. PMID: 35120475Free PMC Article
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Prevalence, pattern and severity of molar incisor hypomineralisation in 8- to 10-year-old school children in Ile-Ife, Nigeria.
Oyedele TA, Folayan MO, Adekoya-Sofowora CA, Oziegbe EO, Esan TA
Eur Arch Paediatr Dent 2015 Jun;16(3):277-82. Epub 2015 Mar 19 doi: 10.1007/s40368-015-0175-y. PMID: 25788171
Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning.
Reuland-Bosma W, Reuland MC, Bronkhorst E, Phoa KH
Am J Orthod Dentofacial Orthop 2010 May;137(5):584.e1-9; discussion 584-5. doi: 10.1016/j.ajodo.2009.10.032. PMID: 20451772

Clinical prediction guides

Sexual dimorphism of tooth agenesis patterns in non-syndromic oligodontia in Japanese patients.
Sato A, Arai K
Arch Oral Biol 2021 Apr;124:105038. Epub 2021 Jan 13 doi: 10.1016/j.archoralbio.2021.105038. PMID: 33515980
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
The prevalence of incisor hypomineralisation and its relationship with the prevalence of molar incisor hypomineralisation.
Balmer R, Toumba KJ, Munyombwe T, Godson J, Duggal MS
Eur Arch Paediatr Dent 2015 Jun;16(3):265-9. Epub 2015 Apr 18 doi: 10.1007/s40368-014-0171-7. PMID: 25894246
A study of prevalence and distribution of tooth agenesis.
Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620Free PMC Article
Williams syndrome--oral presentation of 45 cases.
Hertzberg J, Nakisbendi L, Needleman HL, Pober B
Pediatr Dent 1994 Jul-Aug;16(4):262-7. PMID: 7937257

Recent systematic reviews

Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...